scholarly journals Assessment of sentinel lymph node detection by radioisotope scan and methylene blue alone in operable oral cavity cancer to assess its accuracy for metastasis

2021 ◽  
Vol 9 (1) ◽  
pp. 149
Author(s):  
Arpit Jain ◽  
Surabhi Srivastava ◽  
Anuj Gupta ◽  
Naresh Ledwani ◽  
Shikha Tiwari ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Blue Dye ◽  
Methylene Blue Dye ◽  
Female Ratio ◽  
Identification Rate

Background: Squamous cell carcinoma (SCC) is the most common malignancy affecting the oral cavity. It typically metastasizes into the regional cervical lymph nodes before spreading to distant organs.Methods: A prospective study on sentinel lymph node biopsy (SLNB) in early oral cancers using methylene blue dye and sentinel node localisation using pre-operative lymphoscintigraphy and intraoperative gamma probe in early oral cavity cancer.Results: Present study had a male to female ratio of 1.9:1, with (65.5%) male and (34.5%) female patients. Present study had a side distribution of disease more on left side with 138 patients (62.7%) and ratio of left to right was approximately 1.7:1. In present study most predominating gross morphological pattern of growth was ulcerative (35%) followed by ulcero-infilterative (25%). Buccal mucosa was the most common sub-site of origin of carcinoma in oral cavity, followed by tongue, with 83 (37.7%) and 64 (29.1%) patients. Identification rate of methylene blue dye was 91.7% (100 out of 109 patient). Identification rate of radionuclide tracer was 94.6% (105 out of 111 patient). In methylene blue dye group out of 103 metastatic sentinel lymph nodes, 9 metastatic sentinel lymph nodes were detected on IHC.Conclusions: With the above results it can be concluded the SLNB study is liable in detection of actual positive node and can avoid unnecessary neck dissections in patients with SCC with negative sentinel lymph node, as having very low risk of occult lymphatic metastases in the remaining lymphatic drainage.

scholarly journals Factors that affect the false negative rate of sentinel lymph node mapping with methylene blue dye alone in breast cancer

2019 ◽  
Vol 47 (10) ◽  
pp. 4841-4853 ◽  
Author(s):  
Huang Li ◽  
Zhang Jun ◽  
Ge Zhi-Cheng ◽  
Qu Xiang
Keyword(s):  
Breast Cancer ◽  
Methylene Blue ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
False Negative ◽  
False Negative Rate ◽  
Blue Dye ◽  
Methylene Blue Dye ◽  
Clinicopathological Factors

Objective This study aimed to investigate the clinicopathological factors of the false negative rate (FNR) and accuracy of sentinel lymph node biopsy (SLNB) mapping with 1% methylene blue dye (MBD) alone, and to examine how to reduce the FNR in patients with breast cancer. Methods A total of 365 patients with invasive breast carcinoma who received axillary lymph node dissection after SLNB were retrospectively analyzed. SLNB was performed with 2 to 5 mL of 1% MBD. We studied the clinicopathological factors that could affect the FNR of SLNB. Results The identification rate of sentinel lymph nodes (SLNs) was 98.3% (359/365) and the FNR of SLNB was 10.4% (16/154). Multivariate analysis showed that the number of dissected SLNs and metastatic lymph nodes were independent predictive factors for the FNR of SLNB. The FNR in patients with 1, 2, 3, and ≥4 SLNs was 23.53%, 15.79%, 3.85%, and 1.79%, respectively. Conclusions SLNB mapping with MBD alone in patients with breast cancer can produce favorable identification rates. The FNR of SLNB decreases as the number of SLNs rises. Because of side effects of searching for additional SLNs and the FNR, removal of three or four SLNs may be appropriate.

scholarly journals Identification of the sentinel lymph node using hemosiderin in locally advanced breast cancer

2017 ◽  
Vol 44 (6) ◽  
pp. 612-618
Author(s):  
PAULO HENRIQUE WALTER DE AGUIAR ◽  
RANNIERE GURGEL FURTADO DE AQUINO ◽  
MAYARA MAIA ALVES ◽  
JULIO MARCUS SOUSA CORREIA ◽  
AYANE LAYNE DE SOUSA OLIVEIRA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Sentinel Lymph Nodes ◽  
Advanced Breast ◽  
Identification Rate

ABSTRACT Objective: to verify the agreement rate in the identification of sentinel lymph node using an autologous marker rich in hemosiderin and 99 Technetium (Tc99) in patients with locally advanced breast cancer. Methods: clinical trial phase 1, prospective, non-randomized, of 18 patients with breast cancer and clinically negative axilla stages T2=4cm, T3 and T4. Patients were submitted to sub-areolar injection of hemosiderin 48 hours prior to sentinel biopsy surgery, and the identification rate was compared at intraoperative period to the gold standard marker Tc99. Agreement between methods was determined by Kappa index. Results: identification rate of sentinel lymph node was 88.9%, with a medium of two sentinel lymph nodes per patients. The study identified sentinel lymph nodes stained by hemosiderin in 83.3% patients (n=15), and, compared to Tc99 identification, the agreement rate was 94.4%. Conclusion: autologous marker rich in hemosiderin was effective to identify sentinel lymph nodes in locally advanced breast cancer patients.

Methylene Blue Dye: A safe and effective alternative for sentinel lymph node localisation.

2007 ◽  
Vol 33 (9) ◽  
pp. 1134-1134 ◽  
Author(s):  
P VARGHESE ◽  
A ABDELRAHMAN ◽  
S AKBERALI ◽  
A MOSTAFA ◽  
J GATTUSO ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Effective Alternative ◽  
Blue Dye ◽  
Methylene Blue Dye
Sign in / Sign up

Export Citation Format

Share Document