scholarly journals Screening for metabolic syndrome in children aged 10-18 years with parental history of premature coronary artery disease

2018 ◽  
Vol 5 (5) ◽  
pp. 1883
Author(s):  
Anjana H. Rao ◽  
Vinayaka P. Hegade
Keyword(s):  
Coronary Artery Disease ◽  
Metabolic Syndrome ◽  
Coronary Artery ◽  
Hdl Cholesterol ◽  
Premature Coronary Artery Disease ◽  
Study Group ◽  
Parental History ◽  
Low Hdl ◽  
History Of ◽  
Artery Disease

Background: The metabolic syndrome is appearing with increasing frequency in children and adolescents and is characterized by the clustering of abdominal obesity, impaired fasting blood glucose (FBS), hypertriglyceridemia, low HDL cholesterol and hypertension. Objective of this study was to screen for components of metabolic syndrome in children aged 10-18 years with parental history of premature coronary artery disease (CAD) and to compare them with children without parental history of premature coronary artery disease.Methods: A total of 90 children each between the ages of 10-18 years were selected as the study group and comparison group. These children were screened for components of metabolic syndrome like fasting blood sugar, hypertension, obesity and dyslipidemia. Diet and hours of physical activity were assessed. Statistical analysis was carried out through SPSS for windows (version 17.0).Results: The most common component of metabolic syndrome in the study group was abnormal FBS followed by elevated triglycerides, low HDL cholesterol, obesity and hypertension. The mean values of FBS, Systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol, triglycerides were found to be significantly higher in the study group. Children in the study group had a higher mean body mass index (BMI) and a history of excessive oily food intake with a sedentary lifestyle.Conclusions: Children with parental history of premature coronary artery disease have higher incidence of dyslipidemia and abnormal FBS. Children in the study group had a sedentary lifestyle with unhealthy diet practices.

Relation Between Family History of Premature Coronary Artery Disease and the Risk of Death in Patients With Coronary Artery Disease

2016 ◽  
Vol 117 (3) ◽  
pp. 353-358 ◽  
Author(s):  
Ahmed Abdi-Ali ◽  
AbdelAziz Shaheen ◽  
Danielle Southern ◽  
Mei Zhang ◽  
Merril Knudtson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Family History ◽  
Premature Coronary Artery Disease ◽  
Risk Of Death ◽  
History Of ◽  
Artery Disease

P6191Proprotein convertase subtilisin/kexin type 9 (PCSK9) plasma levels are associated with the metabolic syndrome in patients with stable coronary artery disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Caselli ◽  
R Ragusa ◽  
S Del Turco ◽  
G Basta ◽  
A Saraste ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Metabolic Syndrome ◽  
Coronary Artery ◽  
Plasma Levels ◽  
Hdl Cholesterol ◽  
Homa Index ◽  
Cholesterol Levels ◽  
The Metabolic Syndrome ◽  
Artery Disease ◽  
Stable Cad

Abstract Background PCSK9 is a key regulator of serum LDL-cholesterol levels. The relation of PCSK9 with other components of cardiovascular and coronary artery disease (CAD) risk is still debated. Purpose To evaluate the association of PCSK9 plasma levels with cardiovascular and coronary risk profile, in patients with symptoms of suspected stable CAD enrolled in the EVINCI study. Methods PCSK9 was measured in 522 patients (60.4±8.8 years, 318 males) with symptoms of stable CAD Individual risk was characterized by clinical and bio-humoral variables, including lipid/glucose/inflammatory profiles. Obstructive CAD was firstly ruled-in by multimodality non-invasive imaging and, subsequently, assessed by invasive coronary angiography. Results Patients were divided into groups according to PCSK9 quartiles: I (<138 ng/mL), II-III (138–264 ng/mL), and IV (>264 ng/mL) (Table). The prevalence of obstructive CAD at invasive angiography and statin treatment did not differ among groups. Compared with patients in quartile IV, patients in quartile I, had a higher prevalence of metabolic syndrome and higher values of body mass index. Among biomarkers, all cholesterol lipoproteins levels progressively increased from quartile I to IV, while insulin and HOMA index values decreased (Table). At multivariable analyses adjusted for medical treatment, the only clinical or bio-humoral variables independently associated with PCSK9 levels were presence of the metabolic syndrome (Coeff. −0.195, SE 0.05, p<0.0001) and HDL cholesterol levels (Coeff. 0.444, SE 0.06, p<0.0001), respectively. Table 1 Clinical Variables Quartile I Quartile II–III Quartile IV Biomarkers Quartile I Quartile II–III Quartile IV <138 ng/L 138–264 ng/L >264 ng/L <138 ng/L 138–264 ng/L >264 ng/L (n=130) (n=261) (n=131) (n=130) (n=261) (n=131) Age, years 61±9 60±9 61±8 Glucose, mg/dL 110±30 117±41 109±29 Male gender 86 (66) 161 (62) 71 (55) Insulin, mUI/mL 13.3±12.5* 11.3±10.1 10.3±10.1 Family history 38 (29)# 86 (33) 58 (44) HOMA index 3.9±4.5* 3.5±4.1 2.9±3.3 Hypertension 78 (60) 164 (63) 88 (67) Tryglicerides, mg/dL 128±86 128±87 118±68 Hypercholesterolemia 72 (55) 158 (61) 81 (62) Total cholesterol, mg/dL 171±43* 181±45 203±55 Diabetes mellitus 43 (33) 91 (35) 37 (28) LDL, mg/dL 99±36* 104±38 119±45 Metabolic Syndrome 45 (35)# 72 (28) 19 (15) HDL, mg/dL 46±13* 52±15 61±19 BMI, kg/m2 28.02±4.00* 28.03±4.25 26.95±4.56 Total/HDL cholesterol 3.8±1.2* 3.7±1.2 3.5±1.1 Significant CAD at ICA 18 (14) 46 (18) 24 (18) hs-CRP, mg/dL 0.41±0.61 0.39±1.38 0.41±0.83 Statins treatment 68 (52) 143 (55) 58 (44) Interleukin 6, ng/L 1.60±2.75 1.30±2.49 1.30±1.68 Chi square test: #p<0.05. ANOVA: I vs. IV Quartile: *p<0.05. Conclusion In patients with stable CAD, low plasma levels of PCSK9 are associated with the prevalence of metabolic syndrome and its individual components, including, in particular, HDL cholesterol. Acknowledgement/Funding AMGEN grant, EU FP7-CP-FP506 2007 project (grant agreement no. 222915)

A new APOA1 mutation with severe HDL-cholesterol deficiency and premature coronary artery disease

2008 ◽  
Vol 388 (1-2) ◽  
pp. 222-224 ◽  
Author(s):  
Patricia Esperón ◽  
Marcelo Vital ◽  
Víctor Raggio ◽  
Walter Alallón ◽  
Mario Stoll
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Hdl Cholesterol ◽  
Premature Coronary Artery Disease ◽  
Artery Disease
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