scholarly journals Efficacy of sequential therapy versus standard triple therapy versus quinolone-based triple therapy for eradication of Helicobacter pylori infection

2019 ◽  
Vol 6 (6) ◽  
pp. 1898
Author(s):  
Rishabh Sehgal ◽  
Harsimranjit Singh ◽  
Inderpal Singh ◽  
Jyotisterna Mittal ◽  
Kanwerpreet Kaur
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Therapy Group ◽  
Sequential Therapy ◽  
Helicobacter Pylori Infection ◽  
P Value ◽  
Standard Triple Therapy ◽  
Wide Range ◽  
Urease Test ◽  
Significant Difference

Background: Helicobacter pylori colonization is a risk factor for Adenocarcinomas of the distal (noncardia) stomach. The presence of Helicobacter pylori is strongly associated with primary gastric lymphoma. The urea breath test, the stool antigen test, and biopsy-based tests can all be used to assess the success of treatment. Helicobacter pylori is susceptible to a wide range of antibiotics in vitro, monotherapy is not usually successful, probably because of inadequate antibiotic delivery to the colonization niche. Current regimens consist of a PPI or H2 blocker, bismuth citrate and two or three antimicrobial agents given for 7-14 days. Research on optimizing drug combinations to increase efficacy continues. Efficacy of Sequential Therapy versus Standard Triple Therapy versus Quinolone-based Triple Therapy for eradication of Helicobacter pylori infection is done in this study.Methods: This study had been conducted on 150 patients divided into three groups randomly 50 Patients each and were treated with Sequential, Standard and Quinolone based triple therapy respectively. Patients were followed up no sooner than four weeks of completing therapy by rapid urease test to confirm eradication.Results: There was no significant difference with regards to presence of GERD, Gastric Ulcers, Duodenal Ulcers (p value>0.05) except for presence of erosive gastritis which was significantly higher in patients in quinolone group (p value<0.05). The eradication rate was 90%, 86%, 82% in Sequential therapy group, Triple therapy group and Fluroquinolone group respectively. However, there was no statistically significant difference in eradication rates in these groups (p value>0.05).Conclusions: Sequential therapy group had better eradication rates (90%) as compared to standard triple therapy group (86%) and fluroquinolone therapy group (82%) but results were not statistically significant when all three groups were compared together.

Sequential Therapy or Standard Triple Therapy for Helicobacter pylori Infection

2016 ◽  
Vol 23 (3) ◽  
pp. e880-e893 ◽  
Author(s):  
Li Feng ◽  
Mao-Yao Wen ◽  
Yong-Jun Zhu ◽  
Ruo-Ting Men ◽  
Li Yang
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Sequential Therapy ◽  
Helicobacter Pylori Infection ◽  
Standard Triple Therapy

scholarly journals European Registry on the management of Helicobacter pylori infection: features of diagnosis and treatment in Kazan

2020 ◽  
Vol 92 (8) ◽  
pp. 52-59
Author(s):  
S. R. Abdulkhakov ◽  
D. S. Bordin ◽  
R. A. Abdulkhakov ◽  
D. D. Safina ◽  
A. R. Gizdatullina ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Proton Pump Inhibitor ◽  
Triple Therapy ◽  
Proton Pump ◽  
Eradication Therapy ◽  
Helicobacter Pylori Infection ◽  
Rapid Urease Test ◽  
Standard Triple Therapy ◽  
Urease Test ◽  
H Pylori

Background. As part of an observational multicenter prospective study European Registry on the management of Helicobacter pylori infection, conducted on the initiative of the European H. pylori and Microbiota Study Group, the compliance of clinical practice in the management of patients with Helicobacter pylori infection in Kazan with clinical guidelines was assessed. Materials and methods. The data of 437 patients included into the register by clinical sites in Kazan in 20132019 were analyzed. The methods used for the initial diagnosis of H. pylori infection and eradication control were evaluated. The frequency of various eradication therapy regimens prescription was analyzed in 379 cases. Data regarding the effectiveness of eradication therapy was analyzed in 173 patients. Results. The rapid urease test (44.2% of cases) and cytology/histology (60% of cases) were most often used for the initial diagnosis of H. pylori infection; however non-invasive methods such as 13C-urea breath (9.2%), serology (6.2%), H. pylori stool antigen test (2.3%) were less common. In 21.7% of patients two methods of H. pylori detection were used for primary diagnosis. The control test to evaluate the effectiveness of eradication therapy at the recommended timepoint was performed in 46.2% of patients. 13C-urea breath test (31.7%), stool PCR/stool antigen test (28.7%), rapid urease test (22.3%), cytology/histology (26.2% of cases) prevailed in the assessment of eradication rate. Standard triple therapy, including proton pump inhibitor, clarithromycin and amoxicillin was most commonly prescribed as first-line therapy (64.6% of cases). The duration of eradication therapy was 14 days in the majority of cases with pantoprazole as the most common proton pump inhibitor in standard triple therapy regimens (84.8%). The efficacy of 14-day standard triple therapy (mITT) was 87.0%. Conclusion. The results indicate a high frequency of non-invasive methods use for assessing the effectiveness of eradication therapy; however, the overall rate of eradication efficacy assessment is low, limiting the possibility of analyzing the eradication results. The effectiveness of the most common 14-day standard triple first-line therapy in Kazan doesnt reach the recommended 90% eradication level. This could be explained by high rate of pantoprazole use, which is not an optimal proton pump inhibitor in eradication therapy regimens.

scholarly journals OBSERVATIONS IN CONTROLLING HELICOBACTER PYLORI BETWEEN TRIPLE REGIME AND SEQUENTIAL REGIME.

2021 ◽  
Vol 31 (03) ◽  
pp. 155-158
Author(s):  
Muhammad Tahir Shah ◽  
Noreen Azam ◽  
Adil Mehraj ◽  
Muhammad Ilyas ◽  
Mansoor Ahmad
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Therapy Group ◽  
Sampling Technique ◽  
Sequential Therapy ◽  
Operational Definition ◽  
Helicobacter Pylori Infection ◽  
Inclusion Criteria ◽  
Helicobacter Pylori Eradication ◽  
Definition Of

Objective: Comparison between conventional triple regime and sequential regime in controlling of Helicobacter Pylori. Material and Methods: The study was conducted at Medical OPD MH Rawalpindi for six months. The consecutive (nonprobability sampling) technique was used. All patients fulfilling inclusion criteria and diagnosed according to operational definition of Helicobacter Pylori infection were selected. All the information was entered, assessed and results were obtained through SPSS. Results: According to our study the cases mean age was 36.23±10.87 years, ratio between male, female was 1.07:1. overall efficacy achieved in 289 (67.21%) patient (124 in set A and 165 in set B).  So according to results sequential therapy has got much higher results as compared to triple therapy group. Conclusion: It has been proved in our study that the sequential regime has got significantly better results than conventional triple regime in the management of Helicobacter Pylori eradication

Ten and Eight-day Sequential Therapy in Comparison to Standard Triple Therapy for Eradicating Helicobacter pylori Infection

2010 ◽  
Vol 44 (4) ◽  
pp. 261-266 ◽  
Author(s):  
Omero Alessandro Paoluzi ◽  
Emanuela Visconti ◽  
Fabio Andrei ◽  
Claudio Tosti ◽  
Raffaella Lionetti ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Sequential Therapy ◽  
Helicobacter Pylori Infection ◽  
Standard Triple Therapy
Sign in / Sign up

Export Citation Format

Share Document