scholarly journals Correlation of neutrophil lymphocyte ratio with HbA1c in patients of type 2 diabetes mellitus

2021 ◽  
Vol 8 (7) ◽  
pp. 952
Author(s):  
Sanjay Varma ◽  
Manisha Khande ◽  
Preeti Gupta ◽  
Archana . ◽  
Rajeev Lochan Khare ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Control Level ◽  
Poor Glycemic Control ◽  
Low Grade ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Background: Neutrophil lymphocyte is an indicator of subclinical inflammation. Type 2 diabetes mellitus is associated with chronic low-grade inflammation. One of the novel inflammatory markers is hemogram derived neutrophil to lymphocyte ratio. There are very few studies which are directly accessing the relation between NLR and HbA1c, so in the present study our aim to correlate neutrophil lymphocyte ratio with glycemic control in patients having type 2 diabetes.Methods: Hospital based observational cross section study was carried out at department of medicine, Pt JNMMC and Dr BRAM Hospital, Raipur, between September 2018 to August 2019. 105 patients with type 2 diabetes mellitus according to ADA criteria who were aged more than 18 years were included in the study. Relevant investigation and complete blood count were performed. Microsoft excel and SPSS version 25 were used for collection and analysis of the data, p<0.05 was considered as significant.Results: Out of 105 patients who were given the consent for the study, the ration of male is to female was 1:0.98, mean age of all the patients was 51.77±10.56 years, mean neutrophil lymphocyte ratio among the patients was 6.30±2.646, HbA1c count more than ≥9 was 54 (51.27%). NLR had a positive correlation with HbA1c and was found to be an independent predictor of poor glycemic control in patients with type 2 diabetes mellitus.Conclusions: Increased NLR is associated with elevated HbA1c and poor glycemic control. Type NLR should be used as a marker of diabetic control level in addition to HbA1c in type 2 diabetic subjects.

scholarly journals Study of neutrophil lymphocyte ratio in patients with type 2 diabetes mellitus and its correlation with glycemic control

2019 ◽  
Vol 6 (5) ◽  
pp. 1637
Author(s):  
Devamsh G. N. ◽  
Parvathi M. ◽  
Madhumathi R. ◽  
Leela Raghavan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: Neutrophil lymphocyte ratio (NLR) is an indicator of subclinical inflammation. Subclinical inflammation may be associated with increased cardiovascular risk. Raised NLR is associated with metabolic syndrome and is found to be a predictor of cardiovascular disorders. There are only few studies assessing the correlation between NLR and glycemic control. The aim of the present study is to investigate the relationship between NLR and glycemic control in type 2 diabetes patients.Methods: This observational study was conducted in Department of Medicine, Bangalore medical college. 100 patients diagnosed to have type 2 diabetes mellitus were assessed. They were divided into three groups based upon HbA1c levels: Group 1, HbA1c ≤7%; group 2, HbA1c 7-9%, and group 3, HbA1c>9%. Complete blood count and other relevant investigations were performed. SPSS software was used for statistical analysis. T test was used for continuous variables and chi square test for categorical variables. ANOVA test was used to compare three groups. A p value of <0.05 was considered statistically significant.Results: Out of 100 patients, the white blood cell count (WBC count) was higher in group 3 as compared to group 1 and group 2(p 0.008). Similarly, the absolute neutrophil count was higher in group 3 as compared to group 1 and group 2(p.017). The neutrophil lymphocyte ratio (NLR) was significantly higher in group 3 as compared with group 1 and group 2(p.009). NLR had a positive correlation with HbA1c and was found to be an independent predictor of poor glycemic control in patients with type 2 diabetes mellitusConclusions: Our study found a significant positive correlation between NLR and glycemic control. Increased NLR is associated with elevated HbA1c and poor glycemic control. Type 2 diabetes mellitus patients with raised NLR should be evaluated for cardiovascular, renal and ocular complications of diabetes.

scholarly journals Laboratory Parameters of Hemostasis, Adhesion Molecules, and Inflammation in Type 2 Diabetes Mellitus: Correlation with Glycemic Control

2020 ◽  
Vol 17 (1) ◽  
pp. 300 ◽  
Author(s):  
Eleonora Palella ◽  
Rossella Cimino ◽  
Salvatore A. Pullano ◽  
Antonino S. Fiorillo ◽  
Elio Gulletta ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Vascular Complications ◽  
Poor Glycemic Control ◽  
Pai 1

Background: Type 2 diabetes mellitus (T2DM) is characterized by a prothrombotic state, predisposing to vascular complications. Some related markers, linking thrombophilia to hemostasis and inflammation, however, have been poorly explored in relation to patients’ glycemia. We therefore investigated the association of laboratory hemostatic parameters, circulating adhesion molecules (ADMs), white blood cell (WBC) count, and neutrophil/lymphocyte ratio (NLR) with T2DM and glycemic control. Research design: In this study, 82 subjects, grouped into T2DM patients (n = 41) and healthy individuals (n = 41) were enrolled. To evaluate glycemic control, the T2DM cohort was expanded to 133 patients and sub-classified according to glycated hemoglobin (HbA1c) <7% and ≥ 7% (n = 58 and n = 75, respectively). We assessed glycemia, HbA1c, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), platelet and leukocyte parameters, vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and selectins (E-, P-, L-). Results: PT % activity, PAI-1, VCAM-1, WBC, and neutrophil counts were significantly higher in T2DM patients than in healthy subjects. Poor glycemic control (HbA1c ≥ 7%) was correlated with increased PT activity (p = 0.015), and higher levels of E-selectin (p = 0.009), P-selectin (p = 0.012), and NLR (p = 0.019). Conclusions: Both T2DM and poor glycemic control affect some parameters of hemostasis, inflammation, and adhesion molecules. Further studies are needed to establish their clinical utility as adjuvant markers for cardio-vascular risk in T2DM patients.

scholarly journals IMMUNOLOGICAL EVALUATION OF PATIENTS WITH TYPE 2 DIABETES MELLITUS SUBMITTED TO METABOLIC SURGERY

2015 ◽  
Vol 28 (4) ◽  
pp. 266-269 ◽  
Author(s):  
Marisa de Carvalho BORGES ◽  
Guilherme Azevedo TERRA ◽  
Tharsus Dias TAKEUTI ◽  
Betânia Maria RIBEIRO ◽  
Alex Augusto SILVA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Insulin Dose ◽  
Low Grade ◽  
Ileal Interposition ◽  
Insulin Metabolism ◽  
Early Presentation

Background: Immunological and inflammatory mechanisms play a key role in the development and progression of type 2 diabetes mellitus. Aim: To raise the hypothesis that alterations in immunological parameters occur after duodenojejunal bypass surgery combined with ileal interposition without gastrectomy, and influences the insulin metabolism of betacells. Methods: Seventeen patients with type 2 diabetes mellitus under clinical management were submitted to surgery and blood samples were collected before and six months after surgery for evaluation of the serum profile of proinflammatory (IFN-γ, TNF-α, IL-17A) and anti-inflammatory cytokines (IL-4, IL-10). In addition, anthropometric measures, glucose levels and insulin use were evaluated in each patient. Results: No changes in the expression pattern of proinflammatory cytokines were observed before and after surgery. In contrast, there was a significant decrease in IL-10 expression, which coincided with a reduction in the daily insulin dose, glycemic index, and BMI of the patients. Early presentation of food to the ileum may have induced the production of incretins such as GLP-1 and PYY which, together with glycemic control, contributed to weight loss, diabetes remission and the consequent good surgical prognosis of these patients. In addition, the control of metabolic syndrome was responsible for the reduction of IL-10 expression in these patients. Conclusion: These findings suggest the presence of low-grade inflammation in these patients during the postoperative period, certainly as a result of adequate glycemic control and absence of obesity, contributing to a good outcome of surgery.

Sign in / Sign up

Export Citation Format

Share Document