Substitution of alcohol with carisoprodol: A case for concern

Carisoprodol, a centrally acting skeletal muscle relaxant, is not a controlled substance. Despite some evidence for its abuse, certain aspects, e.g. nature of effects, existence of withdrawals, remain unclear till date. We discuss the case of a middle-aged male who presented with carisoprodol use for 10 years. He reported remarkable similarity of its psychoactive effects with alcohol leading to carisoprodol as primary drug of preference. Some withdrawals were also reported which need to be studied further. Awareness for its abuse/dependence potential and ensuring proper regulatory mechanisms is the need of the hour along with stimulation of research to resolve the unclear aspects.

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Double-blind study of metaxalone; use as skeletal-muscle relaxant

JAMA ◽

10.1001/jama.195.6.479 ◽

1966 ◽

Vol 195 (6) ◽

pp. 479-480 ◽

Cited By ~ 3

Author(s):

S. Diamond

Keyword(s):

Skeletal Muscle ◽

Muscle Relaxant ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Skeletal Muscle Relaxant

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Glacial Acetic Acid Catalyzed Synthesis, Physicochemical and Biological Evaluation of Benzodiazepines as Potent CNS Agents

Central Nervous System Agents in Medicinal Chemistry ◽

10.2174/1871524919666190227234238 ◽

2019 ◽

Vol 19 (2) ◽

pp. 146-151

Author(s):

Vipin Kumar ◽

Shweta Verma ◽

Sushil Kumar

Keyword(s):

Skeletal Muscle ◽

Muscle Relaxant ◽

Treated Group ◽

Biological Evaluation ◽

Log P ◽

Control Group ◽

Skeletal Muscle Relaxant ◽

Benzodiazepine Derivatives ◽

Chloro Group ◽

Muscle Relaxant Activity

Background: Approach for green chemistry for chemical synthesis is found to be very efficient as it makes the reaction more easily, less tedious, maximize desired products and minimize by-products. Materials & Methods: Utilizing this approach 1, 5-benzodiazepines and its derivatives have been synthesized and evaluated for skeletal muscle and antianxiety activity. 1, 5-benzodiazepine derivatives have attracted great attention due to its diversity of pharmacological activities and its application in heterocyclic synthesis and medicines. The target compounds were synthesized by first reacting o-phenylenediamine with acetophenone to yield 1, 5-benzodiazepines. In the next step the NH of 1, 5-benzodiazepines were chloroacetylated and then the chloro group was substituted with different anilines. The structures were confirmed on the basis of their TLC, IR, 1H NMR and CHN elemental studies. The physicochemical parameters were determined for BBB penetration through online software. Results: The Log P values of the compounds tested showed that compounds have the potential to be CNS active. The compounds were evaluated for the skeletal muscle relaxant activity and antianxiety activity. It was investigated that 1, 5-benzodiazepines derivatives possess significant differences between control group and treated group. Conclusion: Among these derivatives, the compound bearing chloro group possesses the highest skeletal muscle relaxant and antianxiety activity.

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