scholarly journals Evaluation of omalizumab at certain time intervals in patients with chronic spontaneous idiopathic urticaria

2019 ◽  
Vol 5 (12) ◽  
pp. 351
Author(s):  
Ömer Kutlu ◽  
Engin Karaarslan ◽  
Nermin Karaosmanoğlu ◽  
Hatice Meral Ekşioğlu
Keyword(s):  
Quality Of Life ◽  
Visual Analog Scale ◽  
Statistical Significance ◽  
Activity Score ◽  
Life Questionnaire ◽  
Post Injection ◽  
Analog Scale ◽  
Time Intervals ◽  
Urticaria Activity Score

<p class="abstract"><strong>Background:</strong> In this study, we aimed to evaluate the response of patient treated with omalizumab at certain time intervals through 6 months with pruritus visual analog scale, urticaria activity score and quality of life indexes.</p><p class="abstract"><strong>Methods:</strong> The study was performed on ten patients diagnosed with chronic idiopathic spontaneous urticaria. The disease was assessed by the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) and Dermatology Life Quality Index (DLQI) for every 2 weeks while was assessed by Urticaria Activity Score (UAS-7) and Pruritus Visual Analog Scale (PVAS) for once a week during the 6-month treatment period. Statistical significance was evaluated using the Mann-Whitney <em>U</em> test in SPSS 20.  </p><p class="abstract"><strong>Results:</strong> Pre-treatment values of the DLQI, CU-Q2oL, UAS-7, and PVAS was statistically higher than post-treatment values of these indexes (p&lt;0.05). The mean DLQI/ CU-Q2oL value of the patients before treatment was 17±6.09/ 52.87±22.07 while it was 19.4±16.36 at the end of 2nd-week post-injection per month, and was 21.85±16.56 at the end of 4nd-week post-injection per month during 6-months following. Statistically, PVAS score at the fourth week was higher than 2nd and 4th week (p&lt;0.042, p&lt;0.007).</p><p><strong>Conclusions:</strong> In this study, it was detected that omalizumab had a significant effect on DLQI, CU-Q2oL, UAS-7, PVAS scores in CISU. It can be concluded that significant increase of PVAS score at 4th week compared to scores at 2nd and 3rd week may necessitate the use of omalizumab combined with antihistamines at 4th week of the treatment.</p>

scholarly journals Evaluation of edna: arts and dance for older people

2016 ◽  
Vol 20 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Ann Skingley ◽  
Stephanie De'Ath ◽  
Luci Napleton
Keyword(s):  
Quality Of Life ◽  
Mixed Methods ◽  
Older People ◽  
Statistical Significance ◽  
Small Scale ◽  
Control Group ◽  
Life Questionnaire ◽  
Content Type ◽  
Art Forms

Purpose – The purpose of this paper is to evaluate the impact on health and well-being of participation in dance and arts activities by older people living in the community. Design/methodology/approach – A small-scale, mixed methods research design comprising pretest-posttest evaluation of a three month dance and arts programme. Two groups of older people underwent physical measures and completed a self-report quality of life questionnaire. Written comments and interview data were also gathered. Findings – Physical tests (n=14) demonstrated improvements in posture, shoulder mobility and balance in both groups following the intervention, with some measures reaching statistical significance. Quality of life evaluations (n=21) also showed improvement, with the mental health subscale reaching statistical significance. Qualitative data showed that participants enjoyed the programme and felt physical, psychological and social benefits. Research limitations/implications – The research involved only a small sample of volunteers and a limited programme length which limits its generalisability. The absence of a control group means that causality cannot be inferred. Future research should extend recruitment to a wider geographical area and a longer intervention which includes a control group. Practical implications – Future arts interventions for older people should include consultation prior to, and throughout the project. Commissioners should consider supporting arts for health projects, building in additional funding for evaluative work. Originality/value – This study has added to the evidence base through combining art forms within a mixed methods framework, illustrating the interplay between the art forms, the outcomes and the potential role of social context.

scholarly journals DISCORDANCE IN GOALS OF CARE BETWEEN PATIENTS WITH ADVANCED CANCER AND THEIR CAREGIVERS: DOES AGE PLAY A ROLE?

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S54-S54
Author(s):  
Amy R Lipson ◽  
Sara Douglas
Keyword(s):  
Quality Of Life ◽  
Advanced Cancer ◽  
Visual Analog Scale ◽  
Treatment Decisions ◽  
Analog Scale ◽  
Goals Of Care ◽  
The Impact

Abstract Cancer is considered a family disease as the caregivers (CG’s) role extends beyond providing care as they can also help facilitate treatment decisions. While much has been reported in the literature about patient (PT) goals of care (GoC), little is known about discordance between PT and CG GoC and the impact of PT age. The variables of interest were PT and CG identified GoC using a 100-point visual analog scale (VAS) with anchors of quality of life (0) and survival (100). Discordance was defined as a &gt; 40 point difference on the VAS. The GoC data reported here were those obtained at enrollment and prior to subject’s death. A sample of 235 PTs and CGs of PTs diagnosed with advanced cancers were included in the study. Mean age for the PTs was 64.7 (SD=10.5, range =21-88) with 54% being &gt; 65. At enrollment, 28.7% of the PT-CG pairs of those PTs 65 years (X2 (1)=1.06, p=.304). At death, 61.8% (X2 (1)=31.04 &lt;.001, Φ=.49) with discord at enrollment had discord at death. For patients who were older, 66.7% who had discord at enrollment also had discord at death and for patients

Customized Foot Insoles Have a Positive Effect on Pain, Function, and Quality of Life in Patients with Medial Knee Osteoarthritis

2013 ◽  
Vol 103 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Søren Thorgaard Skou ◽  
Lea Hojgaard ◽  
Ole H. Simonsen
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older Adults ◽  
Knee Osteoarthritis ◽  
Visual Analog Scale ◽  
Oxford Knee Score ◽  
Analog Scale ◽  
Custom Made ◽  
Arch Support

Background: Knee osteoarthritis (KOA) is a prevalent degenerative disease in older adults. Treatment strategies, including insoles, focus on reducing pain and physical disability. In medial KOA, insoles have been studied extensively with conflicting results, possibly due to heterogeneity in outcome measures and the intervention. We sought to investigate the effect of custom-made laterally wedged insoles on pain, function, and quality of life in patients with medial KOA. Methods: Fifty-one consecutive patients with medial KOA were prescribed custom-made insoles with arch support and a 5.0° to 8.7° lateral wedge. At follow-up, 42 of the 51 participants (22 men; mean age, 63 years; mean Kellgren-Lawrence, 3.4) participated. Retrospectively, participants were asked to rate the pain intensity in their affected knee before and after the intervention measured on a visual analog scale after 30 min of physical activity (primary outcome), at rest, at night, and after 50 m of walking. Additionally, they completed the Oxford Knee Score and the EQ-5D. The paired-samples t test was applied in the statistics. Results: The visual analog scale score after 30 min of physical activity was significantly reduced after the intervention (mean, 3.3 cm; 95% confidence interval, 2.1–4.5 cm; P &lt; .001). The same significant changes were found in all of the secondary outcomes. Conclusions: There was a significant reduction in pain and improvements in function and quality of life with custom-made laterally wedged insoles with arch support in older adults with mild-to-severe medial KOA. The customization of laterally wedged insoles may be essential for the effect in medial KOA. (J Am Podiatr Med Assoc 103(1): 50–55, 2013)

scholarly journals Calidad de vida relacionada con la salud en personas con hipertensión y diabetes mellitus

2021 ◽  
Vol 20 (2) ◽  
pp. 316-344
Author(s):  
Dora Inés Parra ◽  
Luís Alberto López Romero ◽  
Lina María Vera Cala
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Visual Analog Scale ◽  
Intervention Group ◽  
Analog Scale ◽  
Calidad De Vida ◽  
Los Grupos

Objetivo: Determinar los factores sociodemográficos y clínicos asociados a la Calidad de Vida relacionada con la salud (CVRS) en personas con hipertensión arterial y diabetes mellitus tipo 2.Métodos: Estudio analítico de corte transversal en una muestra de 184 usuarios de un programa de control de riesgo cardiovascular en Bucaramanga (Colombia). Se utilizó el instrumento EQ-5D-3L para evaluar la calidad de vida. Un modelo de regresión lineal múltiple fue llevado a cabo usando como desenlace la Escala Visual Análoga y como posibles predictores las dimensiones del EQ-5D, ajustando por edad, sexo, grupo de intervención (variable instrumental) y variables clínicas como la patología de base y el control de la misma.Resultados: La mediana de edad fue 63 años, 73,3% mujeres, 88,0% nivel socioeconómico bajo; mediana de Presión Arterial Sistólica de 130 mmHg (116,0-145,0) y de HbA1c 5,7% (5,4-6,2) en la población general, hallándose diferencias estadísticamente significativas entre los grupos de patología. La mediana de la Escala Visual Análoga fue de 80(Q1:59-Q3:95) puntos, sin diferencias estadísticamente significativas entre los grupos de patología. Manifestar dolor/malestar, tener problemas en las actividades cotidianas y el no control de la hipertensión arterial disminuyó la percepción de la calidad de vida relacionada con la salud, en 7,5, 18,1 y 7,3 puntos, respectivamente.Conclusiones: La CVRS, en general, fue alta. Esta fue mayor en las personas con diabetes mellitus tipo 2. Factores relacionados con la funcionalidad y control de la enfermedad fueron asociados con una menor percepción de la CVRS. Objective: To determine the sociodemographic and clinical factors associated with health-related Quality of Life (HRQoL) among people with hypertension and type 2 diabetes mellitus.Methods: Analytical cross-sectional study in a sample of 184 users of a cardiovascular risk control program in Bucaramanga (Colombia). The EQ-5D-3L instrument was used to assess quality of life. A multiple linear regression model was carried out using the Visual Analog Scale as the outcome and the dimensions of the EQ-5D as possible predictors, adjusting for age, sex, intervention group (instrumental variable), and clinical variables such as the disease and its control.Results: The median of age was 63 years, 73.3% women, 88.0% low socioeconomic level; Median Systolic Blood Pressure of 130 mmHg (116.0-145.0) and HbA1c 5.7% (5.4-6.2) in the general population, showing statistically significant differences between the pathology groups. The median of Visual Analog Scale was 80(Q1: 59-Q3: 95) points, with no statistically significant differences between the pathology groups. Manifesting pain/discomfort, problems with usual activities and lack of hypertension control decreased the perception of HRQoL, by 7.5, 18.1 and 7.3 points, respectively.Conclusions: The HRQoL in general was high. It was higher among people with type 2 diabetes mellitus. Factors related to the functionality and control of the disease were associated with a lower perception HRQoL.

Ultrasound-Guided BoNT-A (Botulinum Toxin A) Injection Into the Subscapularis for Hemiplegic Shoulder Pain: A Randomized, Double-Blind, Placebo-Controlled Trial

Stroke ◽  
2021 ◽  
Author(s):  
Botao Tan ◽  
Lang Jia
Keyword(s):  
Quality Of Life ◽  
Range Of Motion ◽  
Shoulder Pain ◽  
Scale Score ◽  
Visual Analog Scale ◽  
Visual Analog Scale Score ◽  
Analog Scale ◽  
Modified Ashworth Scale ◽  
Ashworth Scale

Background and Purpose: This study aimed to assess the efficacy of an ultrasound-guided lateral approach for BoNT-A (botulinum toxin A) injections into the subscapularis in patients with hemiplegic shoulder pain. Methods: This single-center trial used a randomized, double-blind, placebo-controlled design. The key inclusion criteria were a visual analog scale score of ≥4 cm and a modified Ashworth scale score of ≥1+. The patients were randomized to receive either BoNT-A injections or a placebo. The outcomes included the visual analog scale score, modified Ashworth scale score, pain-free passive range of motion of the hemiplegic shoulder, Fugl-Meyer assessment score for the upper extremities, and Stroke-Specific Quality-of-Life score. Results: A total of 49 hemiplegic shoulder pain patients were screened, and 36 were included. The participants receiving the BoNT-A injection reported a significant decrease in pain (visual analog scale, −1.39 [95% CI, −2.41 to −0.36]; P =0.002) and spasticity (modified Ashworth scale score for shoulder internal rotation, −0.72 [95% CI, −1.10 to −0.35]; P =0.001; modified Ashworth scale score for shoulder abduction, −0.44 [95% CI, −0.90 to −0.01]; P =0.026) and improved pain-free passive shoulder internal rotation range of motion (14.56 [95% CI, 6.70–21.41]; P <0.001) and quality of life (Stroke-Specific Quality-of-Life upper extremity subscale, P =0.025) compared with those receiving the placebo at the end point. The shoulder abduction range of motion did not significantly improve after the BoNT-A injection at the end point ( P =0.127). In addition, the patients in the BoNT-A group showed significant improvements in the visual analog scale score and shoulder external rotation range of motion at the 12-week follow-up. No injection-related adverse events were observed during or after the interventions in either group. Conclusions: The ultrasound-guided lateral approach for BoNT-A injections into the subscapularis is a precise and reliable method for reducing pain and spasticity and improving quality of life in stroke survivors with hemiplegic shoulder pain. Registration: URL: https://www.chictr.org.cn ; Unique identifier: ChiCTR1900023513.

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