Mesonephric Adenocarcinoma of the Vagina Harboring TP53 Mutation

Mesonephric adenocarcinoma (MA) of the female genital tract is a rare but distinct entity, exhibiting unique morphological, immunophenotypical, and molecular characteristics. Vaginal MA is hypothesized to arise from the mesonephric remnants located in the lateral vaginal wall. A 52-year-old woman presented with vaginal bleeding. Physical examination revealed a protruding mass in the left vaginal wall. Pelvic magnetic resonance imaging revealed a 2.5-cm mass arising from the left upper vagina and extending posterolaterally to the extravaginal tissue. The punch biopsy was diagnosed as poorly differentiated adenocarcinoma. She received radical surgical resection. Histologically, the tumor displayed various architectural patterns, including compactly aggregated small tubules, solid cellular sheets, endometrioid-like glands and ducts, intraluminal micropapillae, cribriform structure, and small angulated glands accompanied by prominent desmoplastic stroma. The tubules and ducts possessed hyaline-like, densely eosinophilic intraluminal secretions. The tumor extended to the subvaginal soft tissue and had substantial perineural invasion. Immunostaining revealed positivity for the mesonephric markers, including GATA3, TTF1, and PAX2, while showing very focal and weak positivity for estrogen receptor and negativity for progesterone receptor. Additionally, we observed a complete absence of p53 immunoreactivity. Targeted sequencing analysis revealed that the tumor harbored both activating KRAS p.G12D mutation and truncating TP53 p.E286* mutation. A thorough review of the previous literature revealed that 4.5% (3/67) of vaginal/cervical MAs and 0.9% (1/112) of uterine/ovarian mesonephric-like adenocarcinomas harbor TP53 mutations, indicating that this is very uncommon in malignant mesonephric lesions. In summary, we presented a rare case of vaginal MA uniquely harboring pathogenic TP53 mutation, resulting in p53 aberration.

Applying Software Engineering Design Principles to Agile Architecture

Most enterprise IT systems are very complex with a combination of COBOL and Java programs running on multiple platforms. What is needed is a solid IT architecture that supports the operation and growth of a cross-platform IT system. It must enable the iterative and incremental development of applications that are foreseen in an agile development process. The design concept of such an architecture with its infrastructure and development tool is presented in this chapter. This design concept is based on the design principles and architectural patterns of software engineering. The architecture is a combination of layered, component-based, and service-oriented architectural patterns. The agile development process is based on a model-driven approach. The architecture and development approaches were first introduced in 2004. Since then, many applications have been developed on time and within budget.

AN APPROACH TO ANALYSIS OF ARCHIMATE APPLICATION ARCHITECTURE MODELS USING THE SOFTWARE COUPLING METRIC

Applications architecture is the baseline of any organizational activity, which main goal is to provide the executional environment for businessprocesses in order to deliver products or services to satisfy customer needs and generate revenue. Nowadays, large software engineering projectsalways begin with the architecture design phase, despite the waterfall or agile methodology is used by a software development team. Applicationsarchitecture design is the most important and, at the same time, error-prone stage of the whole software engineering project. It is well-known thatdesign shortcomings made on the design phase may increase drastically to testing and maintenance phases. Further costs to defects fixing may behundred times higher in the later project stages in compare to the design stage on which applications architecture is defined. Common system designsolutions, which were proven on practice and used in many projects, are known as architectural patterns. Software architecture patterns are consideredas building block for system implementation. The most popular and efficient way to share architectural patterns are graphical models that used as anyother blueprints of engineering solutions. Applications architecture models are built to represent system design, whereas, such models are alreadybased on certain patterns as the industry best practices. Hence, in this paper we consider a relevant problem of applications architecture modelsanalysis, which relevance is defined by those fact that designed blueprints of information systems and other software solutions should be carefullychecked for all presumable inefficiencies in order to avoid extra efforts and related costs for defects fixing in the later project stages. It is proposed touse ArchiMate enterprise architecture modeling language, since it can be used not only to represent applications architecture, but is connection tobusiness and technology layers. In order to evaluate applications architecture models, respective ArchiMate metamodel is considered and representedas labeled directed graph, and coupling software metric is selected for analysis. Sample calculations are demonstrated, obtained results are discussed,conclusion and future work directions are formulated.

Middleware Patterns for Cloud Platforms

This chapter explores how traditional system architectures are being affected by the emergence of ‘Uber’ style platform models that provide business services with huge global reach. The specific demands and characteristics of such platforms are discussed which in turn dictate their technical requirements. The chapter will explain how middleware technologies have evolved to support today’s requirements for such massively scalable platform solutions. The latest preferred architectural paradigms dictate the use of micro-services and APIs are central to the design of such platforms. Similarly, event based architectures are another key paradigm that must be supported. The role of modern middleware and cloud technologies to support these newly dominant paradigms will be explained. Key architectural patterns pertinent to global platform solutions are illustrated. The role of modern middleware in fulfilling these patterns is highlighted using real-world examples from the field of open finance.

DEVS-Based Building Blocks and Architectural Patterns for Intelligent Hybrid Cyberphysical System Design

The DEVS formalism has been recognized to support generic open architectures that allow incorporating multiple engineering domains within integrated simulation models. What is missing for accelerated adoption of DEVS-based methodology for intelligent cyberphysical system design is a set of building blocks and architectural patterns that can be replicated and reused in system development. As a start in this direction, this paper offers a notional architecture for intelligent hybrid cyberphysical system design and proceeds to focus on the decision layer to consider DEVS models for basic behaviors such as choice of alternatives, perception of temporal event relations, and recognition and generation of finite state languages cast into DEVS time segments. We proceed to describe a methodology to define DEVS-based building blocks and architectural patterns for design of systems employing fast, frugal, and accurate heuristics. We identify some elements of this kind and establish their status as minimal realizations of their defined behaviors. As minimal realizations such designs must ipso facto underlie any implementation of the same cognitive behaviors. We discuss architectures drawn from the cognitive science literature to show that the fundamental elements drawn from the fast, frugal, and accurate paradigm provide insights into intelligent hybrid cyberphysical system design. We close with open questions and research needed to confirm the proposed concepts.

Effects of Different Types of Mechanical Loading on Trabecular Bone Microarchitecture in Rats

Mechanical loading is generally considered to have a positive impact on the skeleton; however, not all types of mechanical loading have the same beneficial effect. Many researchers have investigated which types of mechanical loading are more effective for improving bone mass and strength. Among the various mechanical loads, high-impact loading, such as jumping, appears to be more beneficial for bones than low-impact loadings such as walking, running, or swimming. Therefore, the different forms of mechanical loading exerted by running, swimming, and jumping exercises may have different effects on bone adaptations. However, little is known about the relationships between the types of mechanical loading and their effects on trabecular bone structure. The purpose of this article is to review the recent reports on the effects of treadmill running, jumping, and swimming on the trabecular bone microarchitecture in small animals. The effects of loading on trabecular bone architecture appear to differ among these different exercises, as several reports have shown that jumping increases the trabecular bone mass by thickening the trabeculae, whereas treadmill running and swimming add to the trabecular bone mass by increasing the trabecular number, rather than the thickness. This suggests that different types of exercise promote gains in trabecular bone mass through different architectural patterns in small animals.

Application of Territorial Laser Scanning in 3D Modeling of Traditional Village: A Case Study of Fenghuang Village in China

Historical villages bear historical, cultural, architectural, aesthetic, and landscape values, but they are facing a series of dangers and problems during the process of urbanization. Digital survey for traditional villages plays a crucial role in the preservation, planning, and development of this kind of heritage. The introduction of the terrestrial laser scanning technique is essential for heritage surveying, mapping, and modeling due to its advantages of noncontact measurement, accurate sensing of complex objects, and efficient operation. In recent years, TLS and related processing software (“SCENE”) have been widely presented as effective techniques for dealing with the management and protection of historical buildings in Fenghuang village. Thus, this paper highlights the process of using laser scanning to obtain architectural data, process point clouds, and compare the characteristics of historical buildings in Fenghuang village. The cloud-to-cloud registration technique is applied to build point clouds. As a result of model construction, some architectural patterns are summarized in this village, such as the spatial sequence of ancestral halls, the dominant position of memorial halls, and the character of building decorations and roof slopes. Furthermore, a BIM model is also explained to fulfill the statistical function for architectural components. In the future, more research can be fulfilled based on the built point cloud model, which will be beneficial for the development of the whole village.