scholarly journals Comparative study of oxiport laryngoscope blade versus miller laryngoscope blade for intubation in neonates and infants during general anesthesia, a prospective randomized controlled study

2021 ◽  
Vol 8 (3) ◽  
pp. 356-360
Author(s):  
Nimit Gandhi ◽  
Swati Bhatt ◽  
Anisha Goswami
Keyword(s):  
Heart Rate ◽  
Comparative Study ◽  
General Anesthesia ◽  
Final Analysis ◽  
Laryngoscope Blade ◽  
Controlled Study ◽  
P Value ◽  
Average Heart Rate ◽  
Randomized Controlled ◽  
Neonates And Infants

Neonates and infants are prone to oxygen desaturation during the induction of general anethesia. Pharyngeal oxygen insufflation has been shown to delay the onset and severity of desaturation during apnea. We took this comparative study with the hypothesis that Oxiport Blade delays the time of onset as well as severity of desaturation as compared to Miller Blade. Eighty neonates and infants undergoing general anesthesia with endotracheal intubation were recruited and randomly assigned into two groups:-Oxiport or Miller. (Laryngoscopy performed with Oxiport or Miller Blade respectively). Results were observed in terms of lowest SPO2 attained during Intubation with each Blade, time for 1% desaturation from baseline, desaturation rate, time for intubation and Heart rate. Data from 80 patients were available for final analysis: Oxiport(n=40)-Group O and Miller(n=40)-Group M. Mean lowest SPO2 attained during laryngoscopy in Group O was 97.77±2.81 and with Group M was 92.42±3.71 with a P-value<0.001. The Rate of Saturation achieved in Group O was 0.091±0.018 sec as compared to 0.342±0.122 sec in Group M and p value was <0.001. The time for 1% desaturation from baseline in Group O was 17.69±3.18 sec as compared to 10.4 ±2.09 sec in Group M with p value<0.001. The time for intubation and average heart rate were comparable in both the groups. Apnoeic Laryngeal Oxygen insufflation with Oxiport Blade decreases the incidence and severity of desaturation during intubation in neonates and infants.

scholarly journals Reliable and rapid smooth extubation after Ketofol for induction of general anesthesia in Laparoscopic Drilling of polycystic ovary: A randomized controlled trial

2020 ◽  
Author(s):  
Atef Mohamed Sayed Mahmoud ◽  
Joseph Makram Botros ◽  
Safaa Gaber Ragab
Keyword(s):  
General Anesthesia ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Controlled Study ◽  
Double Blind ◽  
Randomized Controlled ◽  
Airway Response ◽  
American Society ◽  
American Society Of Anesthesiologists ◽  
Better Than

Abstract Background the outcome of ketofol on the hemodynamics and the airway response during induction of general anesthesia has been studied before. Its effect on smoothness of extubation has not been studied before. So, we aimed to assess the effect of ketofol on the smoothness of extubation and compare it with propofol only for induction of general anesthesia. Methods This double-blind, randomized, and controlled study was conducted on one hundred and six American Society of Anesthesiologists Physical status ''ASA PS'' class I and II female patients aged 18–40 years old and scheduled for laparoscopic drilling for polycystic ovary disease under general anesthesia. The patients were assigned into one of two groups (53) patients each; group KP = ketofol and group P = propofol. Results There was good sedation score during suction and extubation in the ketofol group. Airway response and smoothness of extubation were better in the ketofol group better than the propofol group. Conclusion Ketofol as an induction anesthetic agent was effective in attenuating the airway response during extubation more than profofol only. Trial registration: This trial was retrospectively registered at the Clinical Trial.gov with the Identification Number: NCT04365686.

scholarly journals Variable versus fixed-rate infusion of phenylephrine during cesarean delivery: a randomized controlled trial

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ahmed Hasanin ◽  
Sara Habib ◽  
Yaser Abdelwahab ◽  
Mohamed Elsayad ◽  
Maha Mostafa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Cesarean Delivery ◽  
Controlled Trial ◽  
Controlled Study ◽  
Lower Systolic Blood Pressure ◽  
Randomized Controlled ◽  
Phenylephrine Infusion ◽  
Infusion Regimen

Abstract Background Phenylephrine is the most commonly used vasopressor for prophylaxis against maternal hypotension during cesarean delivery; however, the best regimen for its administration is not well established. Although variable infusion protocols had been suggested for phenylephrine infusion, evidence-based evaluation of variable infusion regimens are lacking. The aim of this work is to compare variable infusion, fixed on-and-off infusion, and intermittent boluses of phenylephrine for prophylaxis against maternal hypotension during cesarean delivery. Methods A randomized controlled study was conducted, including full-term pregnant women scheduled for elective cesarean delivery. Participants were divided into three groups which received phenylephrine by either intermittent boluses (1.5 mcg/Kg phenylephrine), fixed on-and-off infusion (with a dose of 0.75 mcg/Kg/min), or variable infusion (with a starting dose of 0.75 mcg/Kg/min). The three groups were compared with regard to frequency of: maternal hypotension (primary outcome), second episode hypotension, reactive hypertension, and bradycardia. Other outcomes included heart rate, systolic blood pressure, physician interventions, and neonatal outcomes. Results Two-hundred and seventeen mothers were available for final analysis. The 2 infusion groups showed less incidence of maternal hypotension {26/70 (37%), 22/71 (31%), and (51/76 (67%)} and higher incidence of reactive hypertension compared to the intermittent boluses group without significant differences between the two former groups. The number of physician interventions was highest in the variable infusion group compared to the other two groups. The intermittent boluses group showed lower systolic blood pressure and higher heart rate compared to the two infusion groups; whilst the two later groups were comparable. Conclusion Both phenylephrine infusion regimens equally prevented maternal hypotension during cesarean delivery compared to intermittent boluses regimen. Due to higher number of physician interventions in the variable infusion regimen, the current recommendations which favor this regimen over fixed infusion regimen might need re-evaluation.

scholarly journals Optimal Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea Reduces Daytime Resting Heart Rate in Prediabetes: A Randomized Controlled Study

2020 ◽  
Vol 9 (19) ◽  
Author(s):  
Sushmita Pamidi ◽  
Florian Chapotot ◽  
Kristen Wroblewski ◽  
Harry Whitmore ◽  
Tamar Polonsky ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Resting Heart Rate ◽  
Randomized Controlled ◽  
Obstructive Sleep

Background It has been widely recognized that obstructive sleep apnea (OSA) is linked to cardiovascular disease. Yet, randomized controlled studies failed to demonstrate a clear cardiovascular benefit from OSA treatment, mainly because of poor adherence to continuous positive airway pressure (CPAP). To date, no prior study has assessed the effect of CPAP treatment on daytime resting heart rate, a strong predictor of adverse cardiovascular outcomes and mortality. Methods and Results We conducted a randomized controlled study in 39 participants with OSA and prediabetes, who received either in‐laboratory all‐night (ie, optimal) CPAP or an oral placebo for 2 weeks. During daytime, participants continued daily activities outside the laboratory. Resting heart rate was continuously assessed over 19 consecutive days and nights using an ambulatory device consisting of a single‐lead ECG and triaxis accelerometer. Compared with placebo, CPAP reduced daytime resting heart rate (treatment difference, −4.1 beats/min; 95% CI, −6.5 to −1.7 beats/min; P =0.002). The magnitude of reduction in daytime resting heart rate after treatment significantly correlated with the magnitude of decrease in plasma norepinephrine, a marker of sympathetic activity ( r =0.44; P =0.02), and the magnitude of decrease in OSA severity (ie, apnea‐hypopnea index [ r =0.48; P =0.005], oxygen desaturation index [ r =0.50; P =0.003], and microarousal index [ r =0.57; P <0.001]). Conclusions This proof‐of‐concept randomized controlled study demonstrates, for the first time, that CPAP treatment, when optimally used at night, reduces resting heart rate during the day, and therefore has positive cardiovascular carry over effects. These findings suggest that better identification and treatment of OSA may have important clinical implications for cardiovascular disease prevention. Registration URL: https:/// www.clini​caltr​ials.gov ; Unique identifier: NCT01156116.

scholarly journals Effects of Tibetan Music on Neuroendocrine and Autonomic Functions in Patients Waiting for Surgery: A Randomized, Controlled Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Antonella Cotoia ◽  
Floriana Dibello ◽  
Fiorenzo Moscatelli ◽  
Alberto Sciusco ◽  
Pietro Polito ◽  
...  
Keyword(s):  
Heart Rate ◽  
Low Frequency ◽  
Controlled Study ◽  
Cognitive Responses ◽  
State Trait Anxiety Inventory ◽  
Autonomic Functions ◽  
High Frequencies ◽  
Randomized Controlled ◽  
Skin Response ◽  
And Control

Background. The aim of this study was to investigate the effects of listening to Tibetan music on anxiety and endocrine, autonomic, cognitive responses in patients waiting for urologic surgery.Methods. Sixty patients waiting for surgery were enrolled to the study. They were randomized in music (M) and control (C) groups. The M group listened to a low-frequency Tibetan music for 30 min (T0–T30) through headphones, and the C group wore headphones with no sound. The State Trait Anxiety Inventory Questionnaire (STAI) Y-1 was administered at T0and T30. Normalized low (LFnu) and high frequencies (HFnu) of heart rate variability, LF/HF ratio, and galvanic skin response (GRS) data were analyzed at T0, T10, T20, T30, and T35. The salivaryα-amylase (sAA) samples were collected at T0, T35, and T45.Results. In the M group, the STAI Y-1 score decreased at T30versus baselinep<0.001, sAA levels decreased at T35versus T0p=0.004, and GSR remained unchanged. In the C group, the STAI Y-1 score remained unchanged, sAA level increased at T35versus T0p<0.001, and GSR slightly increased at T35versus baselinep=0.359. LFnu was lower, and HFnu was significantly higher (T10–T30) in M versus C group. Mean LF/HF ratio slightly reduced in the M group.Conclusions. Our results suggest that preoperative listening to relaxing Tibetan music might be a useful strategy to manage preoperative anxiety.

Sign in / Sign up

Export Citation Format

Share Document