scholarly journals Method development and validation of RP-HPLC for simultaneous estimation of cilnidipine and valsartan in synthetic mixture

2020 ◽  
Vol 7 (3) ◽  
pp. 119-124
Author(s):  
Farhana V Buchiya ◽  
◽  
Hasumati A Raj ◽  
Vineet C Jain ◽  
Mihir Patel ◽  
...  
Keyword(s):  
Method Development ◽  
Synthetic Mixture ◽  
Simultaneous Estimation ◽  
Rp Hplc ◽  
Method Development And Validation ◽  
Development And Validation

scholarly journals Analytical Method Development and Validation of Rp-Hplc Method for Simultaneous Estimation of Pyridoxamine Dihydrochloride and Acetylcysteine in Tablet Dosage Form.

2021 ◽  
Vol 23 (06) ◽  
pp. 992-1000
Author(s):  
Sneha S. Ghule ◽  
◽  
Ashpak M. Tamboli ◽  
Snehal D. Patil ◽  
◽  
...  
Keyword(s):  
High Performance ◽  
Method Development ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Rp Hplc ◽  
System Suitability ◽  
Validation Parameters ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Tablet Dosage

A reverse-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Pyridoxamine dihydrochloride and Acetylcysteine in the marketed formulation is developed. Chromatography carried out at 30oc temperature on Agilent Zorbax Bonus-RP (250 x 4.6 mm, 5 µ) coloum. Coloum using a mobile phase 0.1% trifluroacetic acid in water: acetonitrile (80:20v/v) with flow rate 1ml/min (DAD scan at 210nm). Validation parameters such as system suitability, linearity, precision, accuracy are considered as reported International Conference on Harmonization guidelines. The retention times for Pyridoxamine dihydrochloride and Acetylcysteine are 2 min and 3.4 min. The linearity range for Pyridoxamine dihydrochloride and Acetylcysteine is 30-70 µg/ml and 180-420 µg/ml. The %RSD for accuracy was found to be less than 2%. Hence the proposed method was found to be accurate, precise, reproducible, and specific and can be used for simultaneous analysis of these drugs in tablet formulation.

scholarly journals Method Development and Validation for Simultaneous Estimation of Olmesartan Medoxomil and Hydrochlorothiazide By RP-hPLC

2014 ◽  
Vol 30 (1) ◽  
pp. 195-201 ◽  
Author(s):  
Suryadevara Vidyadhara ◽  
Reddyvalam Sasidhar ◽  
Ballipalli Rao ◽  
Koduri Tejaswi ◽  
Marupudi Reshma
Keyword(s):  
Method Development ◽  
Olmesartan Medoxomil ◽  
Simultaneous Estimation ◽  
Rp Hplc ◽  
Method Development And Validation ◽  
Development And Validation
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