Decreased retinal microvasculature densities in pterygium

AIM: To investigate the retinal vascular network alterations in eyes of patients with pterygium. METHODS: Totally 18 left eyes from 18 female pterygium patients and 18 left eyes from 18 female healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) images were generated of the superficial retinal layer and deeper retinal layer of the macular retina for each eye. The microvascular (MIR) and macrovascular (MAR) densities were calculated and MIR, MAR, and total microvascular (TMI) density was compared in the healthy control and pterygium groups. RESULTS: In pterygium group, in the superficial retinal layer, the vascular density in superficial MIR, superior right (SR), inferior right (IR), right (R), superficial central annuli (SC)1, SC2, and SC3 decreased significantly in the macular area (P<0.05). Furthermore, the vascular density in all those decreased regions except R, was significantly and negatively correlated with the disease course (r=-0.6038 to -0.7762, P=0.0008), and the area size of pterygium (r=-0.6043 to -0.9508, P<0.05). For the deeper retinal layer, the density of deep total microvessel (DTMI), deeper MIR, SR, IR, R, DC2, and DC3 decreased significantly in macular area of pterygium patients (P<0.05). Furthermore, the vascular density in all those decreased regions was significantly and negatively correlated with the disease course (r=-0.6901 to -0.7795, P=0.0015), and the area size of pterygium (r=-0.6043 to -0.9563, P<0.05). No statistically significant differences and correlation was found in other region density (|r|<0.47, P>0.05). CONCLUSION: OCTA findings suggest that pterygium patients present with decreased retinal MIR density, and the major vascular alterations occurr mainly on the bitamporal side. The vascular density of the superficial SC1, SC2, SC3 adjacent to the foveal and deep layer of DC2, DC2 regions, significantly decreased.

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Decreased Retinal Microvasculature Densities in Pterygium

10.21203/rs.2.9802/v1 ◽

2019 ◽

Author(s):

Feng Wang¹* ◽

Lin-Hong Ye¹²* ◽

Wen-Qing Shi¹ ◽

Biao Li¹ ◽

Qi Lin¹ ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Vascular Density ◽

Retinal Layer ◽

Optical Coherence ◽

Disease Course ◽

Macular Area ◽

Control Subjects ◽

Retinal Microvasculature ◽

Healthy Control

Abstract Abstract Purpose To investigate the retinal vascular network alterations in eyes of patients with pterygium. Method 18 left eyes from 18 female pterygium patients and 18 left eyes from 18 female healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) images were generated of the superficial retinal layer (SRL) and deeper retinal layer (DRL) of the macular retina for each eye. The microvascular (MIR) and macrovascular (MAR) densities were calculated and MIR, MAR, and total MIR (TMI) density was compared in the healthy control and pterygium groups. Results In pterygium group, in the SRL, the vascular density in SMIR (superficial MIR), SR, IR, R, SC1, SC2 and SC3 decreased significantly in the macular area (P<.05). Furthermore, the vascular density in all those decreased regions except R, was significantly and negatively correlated with the disease course ( r=-0.6038 to -0.7762, P=0.0008), and the area size of pterygium (r=-0.6043 to -0.9508, P<0.05). For the DRL, the density of DTMI, DMIR (deeper MIR), SR, IR, R, DC2 and DC3 decreased significantly in macular area of pterygium patients (P<.05). Furthermore, the vascular density in all those decreased regions was significantly and negatively correlated with the disease course (r=-0.6901 to -0.7795, P=0.0015), and the area size of pterygium (r=-0.6043 to -0.9563, P<0.05). No statistically significant differences and correlation was found in other region density (|r|＜0.47, P>0.05). Conclusion OCTA findings suggested that pterygium patients present with decreased retinal MIR density, which was negatively correlated with the disease course and the area size of pterygium.

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Decreased Retinal Microvasculature Densities in Pterygium

10.21203/rs.2.24138/v1 ◽

2020 ◽

Author(s):

Feng Wang¹* ◽

Lin-Hong Ye¹²* ◽

Wen-Qing Shi¹ ◽

Biao Li¹ ◽

Qi Lin¹ ◽

...

Keyword(s):

Vascular Network ◽

Vascular Density ◽

Retinal Layer ◽

Disease Course ◽

Macular Area ◽

Retinal Microvasculature ◽

Healthy Control

Abstract Purpose To investigate the retinal vascular network alterations in eyes of patients with pterygium. Method 18 left eyes from 18 female pterygium patients and 18left eyes from 18female healthy control subjectswere enrolled.Optical coherence tomography angiography(OCTA) images were generated of the superficial retinallayer (SRL) and deeper retinal layer (DRL) of the macular retina for each eye. The microvascular(MIR) and macrovascular (MAR) densities were calculated and MIR, MAR, and total MIR (TMI) density was compared in the healthycontrol and pterygium groups. Results In pterygium group,in the SRL,the vascular density in SMIR (superficial MIR), SR(superior right), IR(inferior right), R(right), SC(superficial central annuli)1, SC2 and SC3decreased significantly in the maculararea (P<.05). Furthermore, the vascular density in all those decreased regions except R, was significantly and negatively correlated with the disease course ( r=-0.6038 to -0.7762, P=0.0008), and the area size of pterygium (r=-0.6043 to -0.9508, P<0.05). For the DRL, the densityof DTMI, DMIR (deeper MIR), SR, IR, R, DC2 and DC3 decreased significantly in macular area of pterygium patients (P<.05). Furthermore, the vascular density in all those decreased regions was significantly and negatively correlated with the disease course (r=-0.6901 to -0.7795, P=0.0015), and the area size of pterygium(r=-0.6043 to -0.9563, P<0.05). No statistically significant differences and correlation was foundin other region density (|r|＜0.47, P>0.05). Conclusion OCTA findings suggested that pterygium patients present with decreased retinal MIR density, which was negatively correlated with the disease course and the area size of pterygium.

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Assessment of Macular Capillary Perfusion by Optical Coherence Tomography Angiography on Quiescent Unilateral Anterior Pediatric Uveitis

10.21203/rs.3.rs-967105/v1 ◽

2021 ◽

Author(s):

Junyan Xiao ◽

Yi Qu ◽

Chan Zhao ◽

Hang Song ◽

Anyi Liang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Foveal Avascular Zone ◽

Flow Density ◽

Vascular Density ◽

Optical Coherence ◽

Pediatric Uveitis ◽

Retinal Microvasculature ◽

Capillary Plexus ◽

Fellow Eyes

Abstract Purpose: Using spectral domain optical coherence tomography angiography (SD-OCTA) to evaluate tomographic and microvascular parameters in the macula in quiescent unilateral anterior pediatric uveitis (APU) patients.Methods: Forty-two eyes of 21 patients diagnosed with unilateral APU and 21 eyes of 21 normal controls (NC) were included in this study. 6*6 mm macular scanning mode of SD-OCTA was used for all subjects. The central macular thickness (CMT), subfoveal choroidal thickness (SFCT), vascular density (VD) of superficial capillary plexus (SCP) and the deep capillary plexus (DCP), the foveal avascular zone (FAZ) area, and choriocapillary flow density (CFD) were analyzed and compared among affected, fellow, and NC eyes. Correlation analysis were used to evaluate the potential correlating factors with CFD.Results: DCP VD and CFD were significantly lower in quiescent affected eyes as compared to fellow and NCs eyes (DCP VD both p<0.001; CDF1.0: p=0.012 and p=0.003; CDF1.5: p=0.015 and p=0.006; CDF3.0: p=0.036 and p=0.010, respectively). SCP VD, DCP VD and CMT were significantly lower in the fellow eyes as compared to NC eyes (p=0.021; p<0.001; p=0.037, respectively); CFD was negatively correlated with FAZ and CMT in affected eyes and fellow eyes. No significant differences were detected in FAZ among the 3 groups (p > .05).Conclusions: As compared to NC eyes, both retinal and choroidal microvasculature were impaired in eyes with quiescent APU; retinal microvasculature in unaffected fellow eyes of unilateral APU was also impaired. OCTA is a useful technology for detection of subclinical microvascular changes in APU and may be useful as an additional prognostic tool.

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High myopia and macular vascular density: an optical coherence tomography angiography study

BMC Ophthalmology ◽

10.1186/s12886-021-02156-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yang Jiang ◽

Shang Lou ◽

Ying Li ◽

Youxin Chen ◽

Thomas Chengxuan Lu

Keyword(s):

Optical Coherence Tomography ◽

High Myopia ◽

Optical Coherence Tomography Angiography ◽

Vascular Density ◽

Retinal Layer ◽

Optical Coherence ◽

Retinal Layers ◽

The Individual

Abstract Objective To investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography (OCTA). Method OCTA was performed on 35 eyes with HM with spherical equivalence (SE) > − 6.00D and 35 eyes with NHM with SE ≤ -6.00D. Vascular densities of the macula (overall macula, fovea, parafovea, superior hemi and inferior hemi) were measured in each of the superficial, deep and choriocapillaris layers of the retina. Results In the superficial retinal layer, overall macular VFD was significantly higher in the NHM compared to the HM group (51.27 ± 3.74 vs. 48.07 ± 5.69, p < 0.05). There were significant differences between the NHM and HM in parafovea (52.58 ± 5.78 vs. 49.4 ± 6.43, p < 0.05), superior-hemi (53.38 ± 4.03 vs 49.78 ± 6.84, p < 0.05) and inferior-hemi regions (53.49 ± 4.61 vs 49.05 ± 6.41, p < 0.05), but not in the fovea region. Similarly, in the deep retinal layer, overall macular VFD was significantly higher in the NHM group compared to the HM group (58.69 ± 2.46 vs. 56.90 ± 4.08, p < 0.05). There was significant differences between the HM and NHM in superior-hemi region (61.97 ± 2.68 vs. 60.08 ± 3.98, p < 0.05), but not in the fovea, parafovea, and inferior-hemi region. In the choriocapillaris, there was no difference in the overall macular VFD, nor any of the individual sectors between the HM and the NHM groups. Conclusion VFD in the superficial and deep retinal layers of the macula are significantly increased in the NHM compared to HM eyes. This is not the case in the choroidal capillary layers of the retina.

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Macular capillary plexuses after epiretinal membrane surgery: an optical coherence tomography angiography study

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2017-311188 ◽

2017 ◽

Vol 102 (8) ◽

pp. 1086-1091 ◽

Cited By ~ 20

Author(s):

Yoon Jeon Kim ◽

Seungmo Kim ◽

Joo Yong Lee ◽

June-Gone Kim ◽

Young Hee Yoon

Keyword(s):

Optical Coherence Tomography ◽

Epiretinal Membrane ◽

Optical Coherence Tomography Angiography ◽

Vascular Density ◽

Retinal Layer ◽

Optical Coherence ◽

Vascular Integrity ◽

Capillary Plexus ◽

Fellow Eyes ◽

Sd Oct

AimsTo investigate macular vascular integrity using optical coherence tomography angiography (OCTA) in patients undergoing vitrectomy for idiopathic epiretinal membrane (ERM) removal and to determine its association with structural and visual outcomes.MethodsForty-three patients with unilateral ERM who were followed for ≥6 months after surgery were included. Ophthalmological evaluations included best-corrected visual acuity (BCVA) and spectral-domain OCT (SD-OCT) before surgery and 6 months after surgery. We obtained en face OCTA images of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) for both eyes 6 months after ERM removal. We compared eyes with ERM to unaffected fellow eyes as controls and used interocular differences in the analyses.ResultsCompared with the fellow eyes, eyes with ERM after surgery had a lower parafoveal vascular density (VD) and a smaller foveal avascular zone (FAZ) area in both SCP and DCP (all p<0.001). Interocular differences in the FAZ area and parafoveal VD were correlated with preoperative and postoperative central foveal thicknesses (all p<0.05). In addition, interocular differences in macular vascular integrity had a tendency to be correlated with SD-OCT parameters of the inner retinal layers. Finally, greater interocular differences in the FAZ area and parafoveal VD of both plexuses were significantly associated with worse postoperative BCVAs (all p<0.05).ConclusionsAssessing macular capillary plexuses via OCTA may be useful to quantify structural changes of the inner retinal layer and predict visual function in patients undergoing ERM removal surgery.

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Optical Coherence Tomography Angiography Findings in Fabry Disease

Journal of Clinical Medicine ◽

10.3390/jcm8040528 ◽

2019 ◽

Vol 8 (4) ◽

pp. 528 ◽

Cited By ~ 7

Author(s):

Gilda Cennamo ◽

Laura Giovanna Di Maio ◽

Daniela Montorio ◽

Fausto Tranfa ◽

Camilla Russo ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Fabry Disease ◽

Optical Coherence Tomography Angiography ◽

Retinal Vessel ◽

Vessel Density ◽

Vascular Density ◽

Optical Coherence ◽

Lysosomal Storage ◽

Retinal Microvasculature ◽

Capillary Plexus

Background: Fabry disease (FD) is a X-linked recessive lysosomal storage disorder characterized by altered biodegradation of glycosphingolipids. It is a multisystem pathology, also involving ophthalmological systems that show modifications of the vessel wall due to glycosphingolipid deposits. Optical coherence tomography angiography (OCT-A) allows for an objective analysis of retinal microvasculature alterations, evaluating retinal vessel density in macular region. Methods: A total of 54 FD patients (34 females, 20 males, mean age 44.1 ± 15.6 years) and 70 controls (36 females, 34 males, mean age 42.3 ± 15.6 years) were included in this study. We evaluated vessel density in different macular areas (whole image, fovea, and parafovea) of both the superficial capillary plexus (SCP) and of the deep capillary plexus (DCP). Results: In the SCP there was a significantly lower vascular density in patients compared with controls in whole image (49.95 ± 5.17% vs. 51.99 ± 2.52%; p < 0.001), parafovea (52.01 ± 6.69% vs. 54.30 ± 2.61%; p = 0.002), and fovea (22.38 ± 9.01% vs. 29.31 ± 5.84%; p < 0.0001). In the DCP the vessel density was statistically increased in each macular area in patients compared with controls (54.82 ± 8.07% vs. 50.93 ± 5.46%; p = 0.005, 57.76 ± 7.26% vs. 53.59 ± 5.46%; p = 0.0001, and 39.75 ± 8.59% vs. 34.43 ± 8.68%; p < 0.0001 for whole image, parafovea, and fovea, respectively). Conclusion: OCT-A analysis showed that the macular vessel density was significantly reduced in the SCP and increased in the DCP in FD patients compared with controls. These findings, which might be a consequence of the alteration of vascular wall occurring in FD, support the hypothesis that the evaluation of early retinal microvascular network changes could be a useful tool in the clinical evaluation of the disease.

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Reduced Retinal Microvascular Perfusion in Patients With Stroke Detected by Optical Coherence Tomography Angiography

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.628336 ◽

2021 ◽

Vol 13 ◽

Author(s):

Baoyi Liu ◽

Yijun Hu ◽

Guixian Ma ◽

Yu Xiao ◽

Bin Zhang ◽

...

Keyword(s):

Risk Factors ◽

Optical Coherence Tomography ◽

Protective Factor ◽

Optical Coherence Tomography Angiography ◽

Optic Disk ◽

Optical Coherence ◽

Control Subjects ◽

Retinal Microvasculature ◽

Capillary Plexus ◽

Traditional Risk Factors

Currently there is a shortage of biomarkers for stroke, one of the leading causes of death and disability in aging populations. Retinal vessels offer a unique and accessible “window” to study the microvasculature in vivo. However, the relationship between the retinal microvasculature and stroke is not entirely clear. To investigate the retinal microvascular characteristics in stroke, we recruited patients with stroke and age-matched control subjects from a tertiary hospital in China. The macular vessel density (VD) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ) metrics, and optical coherence tomography angiography (OCTA) measured optic disc VD were recorded for analysis. A total of 189 patients with stroke and 195 control subjects were included. After adjusting for sex, visual acuity, systolic and diastolic blood pressure, a history of smoking, levels of hemoglobulin (HbA1c), cholesterol, and high-density lipoprotein (HDL), the macular VD of SCP and DCP in all sectors was decreased in patients with stroke. In the stroke group, the VD around the FAZ and the VD of the optic disk were lower. Logistic regression found the parafovea-superior-hemi VD of DCP > 54.53% [odds ratio (OR): 0.169] as a protective factor of stroke. Using the integration of all OCTA parameters and traditional risk factors, the area under the receiver operating characteristic (AUC) curve of distinguishing patients with stroke was 0.962, with a sensitivity of 0.944 and a specificity of 0.871. Our study demonstrates that the retinal VD is decreased in patients with stroke independently of the traditional risk factors of stroke, which may shed light on the monitoring of stroke using the retinal microvascular parameters.

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Evaluation of Changes in Macular Perfusion Detected by Optical Coherence Tomography Angiography following 3 Intravitreal Monthly Bevacizumab Injections for Diabetic Macular Edema in the IMPACT Study

Journal of Ophthalmology ◽

10.1155/2020/5814165 ◽

2020 ◽

Vol 2020 ◽

pp. 1-14 ◽

Cited By ~ 2

Author(s):

Ayman G. Elnahry ◽

Ahmed A. Abdel-Kader ◽

Karim A. Raafat ◽

Khaled Elrakhawy

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Optical Coherence Tomography Angiography ◽

Intravitreal Bevacizumab ◽

Vascular Density ◽

Ophthalmological Examination ◽

Optical Coherence ◽

Macular Area ◽

The Impact

Objective. To evaluate macular perfusion changes following intravitreal bevacizumab injections for diabetic macular edema (DME) using spectral domain optical coherence tomography angiography (SD-OCTA). Methods. This study was a prospective noncomparative interventional case series. Treatment naïve patients with DME underwent full ophthalmological examination and SD-OCTA scanning at baseline and after 3 intravitreal bevacizumab injections. Both the 6 × 6 and 3 × 3 mm macular scan protocols were used. Pretreatment and posttreatment OCTA images were automatically aligned using a commercially available retina alignment software (i2k Align Retina software); then the fractal dimension (FD), vascular density (VD), and skeleton VD changes were obtained at the full retinal thickness (Full) and superficial (SCP) and deep (DCP) capillary plexuses after processing images using a semiautomated program. The foveal avascular zone (FAZ) was manually measured and FD was calculated using the FracLac plugin of ImageJ. Results. Forty eyes of 26 patients were included. Following injections, there were an 8.1% increase in FAZ, 1.3% decrease in FD-Full and FD-SCP, 1.9% decrease in FD-DCP, 8% decrease in VD-Full, 9.1% decrease in VD-SCP, 10.6% decrease in VD-DCP, 13.3% decrease in skeleton VD-Full, 12.5% decrease in skeleton VD-SCP, and 16.3% decrease in skeleton VD-DCP in the 6 × 6 mm macular area and a 2.6% decrease in FD-Full, 3.4% decrease in FD-SCP, 11.5% decrease in VD-Full, 14.3% decrease in VD-SCP, and 25.1% decrease in skeleton VD-SCP in the 3 × 3 mm macular area which were all statistically significant p<0.05. Using univariate and multivariate analysis, the pretreatment FD, VD, and skeleton VD at each capillary layer significantly negatively correlated with the change in FD, VD, and skeleton VD at the corresponding capillary layer, respectively p<0.05. Conclusion. OCTA is a useful noninvasive tool for quantitative evaluation of macular perfusion changes following DME treatment. This trial is registered with NCT03246152.

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Changes in Macular Perfusion Detected by Optical Coherence Tomography Angiography Following 3 Intravitreal Monthly Bevacizumab Injections for Diabetic Macular Edema in the IMPACT Study

10.21203/rs.2.13161/v1 ◽

2019 ◽

Author(s):

Ayman Elnahry ◽

Ahmed A. Abdel-Kader ◽

Karim A. Raafat ◽

Khaled Elrakhawy

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Optical Coherence Tomography Angiography ◽

Intravitreal Bevacizumab ◽

Vascular Density ◽

Ophthalmological Examination ◽

Optical Coherence ◽

Macular Area ◽

The Impact

Abstract Background This study was done to evaluate macular perfusion changes following intravitreal bevacizumab injections for diabetic macular edema (DME) using spectral domain optical coherence tomography angiography (SD-OCTA). Methods This study was a prospective noncomparative interventional case series. Treatment naïve patients with DME were recruited at Cairo University retina clinic and underwent full ophthalmological examination and SD-OCTA scanning at baseline and after 3 intravitreal bevacizumab injections. Both the 6X6 and 3X3-mm macular scan protocols were used. Pre and post-treatment OCTA images were automatically aligned using a commercially available retina alignment software (i2k Align Retina software) then the fractal dimension (FD), vascular density (VD), and skeleton VD changes were obtained at the full retinal thickness (Full) and superficial (SCP) and deep (DCP) capillary plexuses after processing images using a semi-automated program. The foveal avascular zone (FAZ) was manually measured and FD was calculated using the FracLac plugin of ImageJ. Results Forty eyes of 26 patients were included. Following injections, there was an 8.1% increase in FAZ, 1.3% decrease in FD-Full and FD-SCP, 1.9% decrease in FD-DCP, 8% decrease in VD-Full, 9.1% decrease in VD-SCP, 10.6% decrease in VD-DCP, 13.3% decrease in skeleton VD-Full, 12.5% decrease in skeleton VD-SCP, and 16.3% decrease in skeleton VD-DCP in the 6X6 mm macular area, and a 2.6% decrease in FD-Full, 3.4% decrease in FD-SCP, 11.5% decrease in VD-Full, 14.3% decrease in VD-SCP, and 25.1% decrease in skeleton VD-SCP in the 3X3 mm macular area which were all statistically significant (p<0.05). There was also an 8.3% increase in the FAZ, 18.5% decrease in skeleton VD-Full, 2.6% decrease in FD-DCP, 8.8% decrease in VD-DCP, and 19.7% decrease in skeleton VD-DCP in the 3X3 mm macular area but these were not statistically significant (p>0.05). Using univariate and multivariate analysis, the pre-treatment FD, VD, and skeleton VD at each capillary layer significantly negatively correlated with the change in FD, VD, and skeleton VD at the corresponding capillary layer respectively (p>0.05). Conclusion OCTA is a useful non-invasive tool for quantitative evaluation of macular perfusion changes following DME treatment. Trial Registration Trial registered at ClinicalTrials.gov on August 11, 2017 (Study ID: NCT03246152).

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Macular Vascular Density Changes following Cataract Surgery in Diabetic Patients: An Optical Coherence Tomography Angiography Study

Journal of Ophthalmology ◽

10.1155/2021/6641944 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Le Feng ◽

Guliqiwaer Azhati ◽

Tingting Li ◽

Fang Liu

Keyword(s):

Optical Coherence Tomography ◽

Cataract Surgery ◽

Optical Coherence Tomography Angiography ◽

Macular Thickness ◽

Diabetic Group ◽

Vascular Density ◽

Diabetic Patients ◽

Optical Coherence ◽

Retinal Microvasculature ◽

Significant Difference

Purpose. Cataracts and diabetes very commonly coexist. The aim of the present study was to quantify the effect of uncomplicated phacoemulsification on retinal microvasculature in diabetic patients by using optical coherence tomography angiography (OCTA). Methods. A prospective observational study of diabetic and nondiabetic patients at baseline and 1 day, 1 week, 1 month, and 3 months after cataract surgery was performed by using OCTA. We measured the macular thickness (MT), superficial capillary plexus (SCP), deep capillary plexuses (DCP), and foveal avascular zone (FAZ) in the 3 × 3 mm macular images. Results. A total of 32 eyes of 32 type 2 diabetic patients and 40 eyes of 40 nondiabetic patients were assessed. There was a significant increase in MT at 1 month and 3 months after surgery in both groups (all P < 0.05 ), but there was no significant difference between the two groups ( P = 0.217 ). At 3 months postoperatively, the SCP level in the diabetic group was significantly higher than that at baseline ( P < 0.05 ). The MT and SCP were negatively correlated with logMAR best-corrected visual acuity (BCVA), while the FAZ area and perimeter were positively correlated with logMAR BCVA in the diabetic group. Conclusions. Our study demonstrated that phacoemulsification can increase macular thickness in both diabetic and nondiabetic patients and increase SCP in diabetic patients within 3 months after surgery. Whether these changes persist for a longer period still needs to be investigated.

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