scholarly journals Review of accelerator-based searches for Neutral Long-Lived Particles

2019 ◽  
Vol 43 (169) ◽  
pp. 638-645
Author(s):  
Marta Losada
Keyword(s):  
Parameter Space ◽  
Coupling Strength ◽  
Current Status ◽  
Next Generation ◽  
Fixed Target ◽  
Beam Dump ◽  
Basic Formalism ◽  
Neutral Lepton

In this paper we present the current status of searches for neutral long-lived particles. The basic formalism that allows the determination of the number of expected long-lived particles is presented. Heavy neutral leptons can be a type of long-lived particles. The main observational motivations for the existence of heavy neutral lepton is covered as well. A summary of the main results from both collider searches and fixed target/beam dump experiments is presented. The outlook for next generation experiments and their impact on the parameter space of coupling strength and mass of heavy neutral leptons is also discussed.

scholarly journals ARS leptogenesis

2018 ◽  
Vol 33 (05n06) ◽  
pp. 1842002 ◽  
Author(s):  
M. Drewes ◽  
B. Garbrecht ◽  
P. Hernández ◽  
M. Kekic ◽  
J. Lopez-Pavon ◽  
...  
Keyword(s):  
Bayesian Analysis ◽  
Parameter Space ◽  
Kinetic Equations ◽  
Lepton Number ◽  
Current Status ◽  
Mass Eigenstates ◽  
Left Handed ◽  
Theoretical Approaches ◽  
The Right

We review the current status of the leptogenesis scenario originally proposed by Akhmedov, Rubakov and Smirnov (ARS). It takes place in the parametric regime where the right-handed neutrinos are at the electroweak scale or below and the CP-violating effects are induced by the coherent superposition of different right-handed mass eigenstates. Two main theoretical approaches to derive quantum kinetic equations, the Hamiltonian time evolution as well as the Closed-Time-Path technique are presented, and we discuss their relations. For scenarios with two right-handed neutrinos, we chart the viable parameter space. Both, a Bayesian analysis, that determines the most likely configurations for viable leptogenesis given different variants of flat priors, and a determination of the maximally allowed mixing between the light, mostly left-handed, and heavy, mostly right-handed, neutrino states are discussed. Rephasing invariants are shown to be a useful tool to classify and to understand various distinct contributions to ARS leptogenesis that can dominate in different parametric regimes. While these analyses are carried out for the parametric regime where initial asymmetries are generated predominantly from lepton-number conserving, but flavor violating effects, we also review the contributions from lepton-number violating operators and identify the regions of parameter space where these are relevant.

scholarly journals Bioanalysis of small-molecule drugs in nasal and paranasal tissues and secretions: Current status and perspectives

2012 ◽  
Vol 10 (3) ◽  
pp. 686-702
Author(s):  
Ana Serralheiro ◽  
Gilberto Alves ◽  
Amílcar Falcão
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Small Molecule ◽  
Intranasal Administration ◽  
Quantitative Measurement ◽  
Current Status ◽  
Small Molecule Drugs ◽  
Development And Validation ◽  
Liquid Chromatographic

AbstractOver the last years, interest in intranasal administration as an alternative and promising route for the delivery of drugs withlocal, systemic, and even central nervous system action has tremendously increased. Accordingly, understanding of the propertiesand characteristics of the nasal cavity as well as the biodisposition processes of drugs into the nasal compartments is acquiringa significant prominence in the field of pharmacology. In this context, the development and validation of bioanalytical methodologies for the quantitative measurement of drugs and their metabolites in nasal and paranasal tissues and/or secretions is of the utmostimportance. However, currently, information concerning bioanalysis of drugs in nasal and paranasal tissues and/or secretionsis scattered. This review aims to provide a valuable overview of the methodologies that have been used for the collectionand preparation of nasal and paranasal samples with special emphasis placed on the review of liquid chromatographic methodsemployed for the quantitative determination of small-molecule drugs and their metabolites in such specimens.

Strain field determination in III–V heteroepitaxy coupling finite elements with experimental and theoretical techniques at the nanoscale

2017 ◽  
Vol 26 (1-2) ◽  
pp. 1-8
Author(s):  
Nikoletta Florini ◽  
George P. Dimitrakopulos ◽  
Joseph Kioseoglou ◽  
Nikos T. Pelekanos ◽  
Thomas Kehagias
Keyword(s):  
Finite Elements ◽  
Strain Field ◽  
Strain Distribution ◽  
Elastic Strain ◽  
Growth Direction ◽  
Current Status ◽  
Interface Plane ◽  
Fe Method ◽  
Semiconductor Nanostructure

AbstractWe are briefly reviewing the current status of elastic strain field determination in III–V heteroepitaxial nanostructures, linking finite elements (FE) calculations with quantitative nanoscale imaging and atomistic calculation techniques. III–V semiconductor nanostructure systems of various dimensions are evaluated in terms of their importance in photonic and microelectronic devices. As elastic strain distribution inside nano-heterostructures has a significant impact on the alloy composition, and thus their electronic properties, it is important to accurately map its components both at the interface plane and along the growth direction. Therefore, we focus on the determination of the stress-strain fields in III–V heteroepitaxial nanostructures by experimental and theoretical methods with emphasis on the numerical FE method by means of anisotropic continuum elasticity (CE) approximation. Subsequently, we present our contribution to the field by coupling FE simulations on InAs quantum dots (QDs) grown on (211)B GaAs substrate, either uncapped or buried, and GaAs/AlGaAs core-shell nanowires (NWs) grown on (111) Si, with quantitative high-resolution transmission electron microscopy (HRTEM) methods and atomistic molecular dynamics (MD) calculations. Full determination of the elastic strain distribution can be exploited for band gap tailoring of the heterostructures by controlling the content of the active elements, and thus influence the emitted radiation.

Determination of Cellular Mechanical Properties by Cell Poking, With an Application to Leukocytes

1990 ◽  
Vol 112 (3) ◽  
pp. 283-294 ◽  
Author(s):  
G. I. Zahalak ◽  
W. B. McConnaughey ◽  
E. L. Elson
Keyword(s):  
Mechanical Properties ◽  
Final Section ◽  
Mechanical Response ◽  
Living Cells ◽  
Micropipette Aspiration ◽  
Current Status ◽  
Technical Description ◽  
Analytical Results ◽  
Simple Models

In this paper we review the cell-poking technique as an approach for investigating the mechanical properties of living cells. We first summarize the rationale for the technique and the mainly qualitative results obtained so far. Then we provide a technical description of the instrument as it is configured at present. This is followed by a discussion of the current status of analytical results available for interpreting cell-poking measurements. In the final section we apply these results to an analysis of unmodulated and modulated lymphocytes and neutrophils, and conclude that the mechanical response of these leukocytes to indentation is not consistent with simple models developed by previous investigators on the basis of micropipette-aspiration experiments.

Determination of the coupling strength from duality and unitarity

1971 ◽  
Vol 36 (5) ◽  
pp. 486-488 ◽  
Author(s):  
K. Igi ◽  
T. Eguchi
Keyword(s):  
Coupling Strength

scholarly journals Investigation of Borosilicate Glasses with Simulated HLW Components and Determination of Their Chemical Durability

2021 ◽  
Vol 8 (1) ◽  
pp. 20218105
Author(s):  
S. M. Shaydullin ◽  
E. A. Belanova ◽  
P. V. Kozlov ◽  
M. B. Remizov ◽  
E. M. Dvoryanchikova
Keyword(s):  
Chemical Durability ◽  
Current Status ◽  
Borosilicate Glasses ◽  
Radiochemical Plant ◽  
Technical Solutions

The paper discusses the current status of the HLW vitrification technology applied at the radiochemical plant of the Mayak PA. Conceptual and technical solutions proposed to develop the technology of vitrification of various types of liquid HLW at the Mayak PA are presented. Compositions of borosilicate glasses with HLW components are described, temperatures of their melting and easy pouring are determined. Chemical durability parameters obtained for the borosilicate glasses are provided.

A Benchmark of Structural Variant Analysis Tools for Next Generation Sequencing Data

2013 ◽  
Vol 2 (4) ◽  
pp. 86-98
Author(s):  
Chatzinikolaou Panagiotis ◽  
Makris Christos ◽  
Dimitrios Vlachakis ◽  
Sophia Kossida
Keyword(s):  
Next Generation Sequencing ◽  
Level Structure ◽  
Atomic Level ◽  
Protein Sequencing ◽  
Next Generation Sequencing Data ◽  
Next Generation ◽  
Sequencing Data ◽  
Variant Analysis ◽  
Generation Sequencing

In language of genetics and biochemistry, sequencing is the determination of an unbranched biopolymer's primary structure. A sequence is a symbolic linear depiction, result of sequencing. This sequence is a succinct summary of the most of the sequenced molecule's atomic-level structure. (Most known is DNA-sequencing, RNA-sequencing, Protein-sequencing and Next-Generation-sequencing)

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