Intrauterine Fetal Blood Transfusion: Descriptive study of the first four years’ experience in Oman

Objectives: Haemolytic disease of the fetus and newborn (HDFN) causes hydrops fetalis. The successful treatment of HDFN has been reported with intrauterine blood transfusion (IUT). This study aimed to describe the initial experience with IUT procedures in Oman. Methods: This retrospective observational study took place at the Royal Hospital and Sultan Qaboos University Hospital Blood Bank, Muscat, Oman, and included all women who underwent IUT procedures in Oman between March 2012 and March 2016. Gestational and neonatal outcomes were assessed, including complications, morbidity, neurodevelopmental sequelae and mortality. Results: A total of 28 IUT procedures for 13 fetuses carried by 11 women were performed. Gestational age at the time of referral ranged from 13–30 weeks, while the median gestational age at first IUT procedure was 26 weeks (range: 19–30 weeks). Indications for the procedure included HDFN caused by anti-D (n = 6), a combination of anti-D and anti-C (n = 4), anti-K (n = 1) and anti-Jsb (n = 1) antibodies and nonimmune hydrops fetalis due to a congenital parvovirus infection (n = 1). Median fetal haemoglobin levels at the beginning and end of the procedure were 4.6 g/dL and 12.8 g/dL, respectively. Most procedures were transplacental intravascular transfusions through the placental umbilical cord root (71.4%), followed by transamniotic intravascular transfusions (14.3%). The overall survival rate was 61.5%, with five deaths; of these, four were intrauterine and one was an early neonatal death due to non-resolved hydrops and severe cardiac dysfunction. Conclusion: As a relatively novel obstetric procedure in Oman, IUT seems to result in a favourable outcome for hydropic fetuses.

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Revisiting the Prevalence of Autism Spectrum Disorder among Omani Children: A multicentre study

Sultan Qaboos University Medical Journal [SQUMJ] ◽

10.18295/squmj.2019.19.04.005 ◽

2019 ◽

Vol 19 (4) ◽

pp. 305 ◽

Cited By ~ 5

Author(s):

Watfa Al-Mamari ◽

Ahmed B. Idris ◽

Samar Dakak ◽

Muna Al-Shekaili ◽

Zuwaina Al-Harthi ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Population Data ◽

Autism Spectrum ◽

Spectrum Disorder ◽

University Hospital ◽

Royal Hospital ◽

Statistical Manual ◽

Sultan Qaboos University ◽

Diagnostic And Statistical Manual ◽

Prevalence Estimates

Objectives: This study aimed to provide an updated estimate of the prevalence of autism spectrum disorder (ASD) among Omani children. Methods: This retrospective descriptive study was conducted from December 2011 to December 2018. Data were retrieved from the three main autism diagnostic centres in Oman: Sultan Qaboos University Hospital, Royal Hospital and Al-Massarah Hospital. The ASD diagnosis was made by experienced clinicians based on the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The overall population prevalence estimates per 10,000 children aged 0–14 years old in Oman were calculated using the denominator of the mid-period population data. Results: A total of 1,705 ASD cases were identified with the majority of cases being male (78.1%). The overall prevalence rate of ASD was estimated at 20.35 per 10,000 children (95% confidence interval: 19.39–21.32) between 2012–2018. Boys were found to have a 3.4-fold higher prevalence of ASD than girls (31.23/10,000 versus 9.07/10,000). Regionally, the majority of cases were found in the capital, Muscat, where the highest prevalence was 36.51 cases per 10,000 children. Conclusion: The prevalence of ASD among Omani children is 15-fold higher than estimates from 2011. This increase can be attributed to improvements in diagnostic services, increased awareness of ASD, better screening programmes and changes in diagnostic criteria. In addition, this increase in prevalence suggests a need for a registry of developmental disabilities and more extensive diagnostic and rehabilitation services in Oman.Keywords: Autism Spectrum Disorder; Epidemiology; Prevalence; Oman.

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Successful ultrasound-guided intrauterine blood transfusion in severe non-immune hydrops fetalis

International Journal of Gynecology & Obstetrics ◽

10.1016/0020-7292(90)90481-y ◽

1990 ◽

Vol 32 (2) ◽

pp. 153-156 ◽

Cited By ~ 2

Author(s):

K. Buckshee ◽

N. Bhatla ◽

V.K. Paul

Keyword(s):

Blood Transfusion ◽

Hydrops Fetalis ◽

Ultrasound Guided ◽

Intrauterine Blood Transfusion

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Intrauterine blood transfusion for non-immune hydrops fetalis due to parvovirus B19 infection

The Lancet ◽

10.1016/0140-6736(90)91642-n ◽

1990 ◽

Vol 336 (8707) ◽

pp. 121-122 ◽

Cited By ~ 34

Author(s):

Peter Soothill

Keyword(s):

Blood Transfusion ◽

Parvovirus B19 ◽

Hydrops Fetalis ◽

Parvovirus B19 Infection ◽

Intrauterine Blood Transfusion

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Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience

Journal of Perinatal Medicine ◽

10.1515/jpm-2017-0124 ◽

2018 ◽

Vol 46 (9) ◽

pp. 968-974 ◽

Cited By ~ 4

Author(s):

Zandrè Bruwer ◽

Nihal Al Riyami ◽

Tamima Al Dughaishi ◽

Fathiya Al Murshedi ◽

Abeer Al Sayegh ◽

...

Keyword(s):

Prenatal Care ◽

Inborn Errors Of Metabolism ◽

Hydrops Fetalis ◽

University Hospital ◽

Inborn Errors ◽

Sultan Qaboos University ◽

Single Center Experience ◽

Diagnostic Work ◽

Work Up ◽

Diagnostic Work Up

Abstract Objective: The purpose of this study was to determine the frequency of non-immune hydrops fetalis (NIHF) among all pregnancies referred for prenatal care at Sultan Qaboos University Hospital (SQUH) during the study period and to evaluate the underlying etiologies of NIH. Study design: All pregnancies referred to SQUH between February 2014 and December 2015 were identified, and all pregnancies meeting the diagnosis of NIHF were included in this study. All cases of NIHF referred to our center during this period underwent standard systematic diagnostic work-up that included biochemical and molecular studies in addition to the standard investigations for hydrops fetalis. Clinical characteristics and results of the diagnostic work-up were retrospectively reviewed. Results: A total of 3234 pregnancies were referred for prenatal care at SQUH during the study period, and 12 pregnancies were affected by NIHF. An underlying diagnosis was established in nine cases, and the majority of cases (7/9) were caused by inborn errors of metabolism (IEM). These included a novel homozygous variant in the AARS2 gene (5/7) and two cases of galactosialidosis (2/7). Conclusion: IEM was a major cause of NIHF in this cohort. The AARS2 variant accounts for a significant number of cases with NIHF in this cohort of Omani patients.

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Characterization of newborns with nonimmune hydrops fetalis admitted to a neonatal intensive care unit

Revista do Hospital das Clínicas ◽

10.1590/s0041-87812003000300001 ◽

2003 ◽

Vol 58 (3) ◽

pp. 125-132 ◽

Cited By ~ 17

Author(s):

Renata Suman Mascaretti ◽

Mário Cícero Falcão ◽

Andrea M. Silva ◽

Flávio Adolfo Costa Vaz ◽

Cléa Rodrigues Leone

Keyword(s):

Mortality Rate ◽

Hospital Stay ◽

Gestational Age ◽

Perinatal Asphyxia ◽

Length Of Hospital Stay ◽

Hydrops Fetalis ◽

Large For Gestational Age ◽

Laboratory Evaluation ◽

Average Weight ◽

Nonimmune Hydrops

PURPOSE: To determine the incidence and characteristics of nonimmune hydrops fetalis in the newborn population. METHOD: A retrospective study of the period between 1996 and 2000, including all newborns with a prenatal or early neonatal diagnosis of nonimmune hydrops fetalis, based on clinical history, physical examination, and laboratory evaluation. The following were analyzed: prenatal follow-up, delivery type, gender, birth weight, gestational age, presence of perinatal asphyxia, nutritional classification, etiopathic diagnosis, length of hospital stay, mortality, and age at death. RESULTS: A total of 47 newborns with hydrops fetalis (0.42% of live births), 18 (38.3%) with the immune form and 29 (61.7%) with the nonimmune form, were selected for study. The incidence of nonimmune hydrops fetalis was 1 per 414 neonates. Data was obtained from 21 newborns, with the following characteristics: 19 (90.5%) were suspected from prenatal diagnosis, 18 (85.7%) were born by cesarean delivery, 15 (71.4%) were female, and 10 (47.6%) were asphyxiated. The average weight was 2665.9 g, and the average gestational age was 35 3/7 weeks; 14 (66.6%) were preterm; 18 (85.0 %) appropriate delivery time; and 3 (14.3%) were large for gestational age. The etiopathic diagnosis was determined for 62%, which included cardiovascular (19.0%), infectious (9.5%), placental (4.8%), hematologic (4.7%), genitourinary (4.8%), and tumoral causes (4.8%), and there was a combination of causes in 9.5%. The etiology was classified as idiopathic in 38%. The length of hospital stay was 26.6 ± 23.6 days, and the mortality rate was 52.4%. CONCLUSIONS: The establishment of a suitable etiopathic diagnosis associated with prenatal detection of nonimmune hydrops fetalis can be an important step in reducing the neonatal mortality rate from this condition.

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