ANALYTICAL  INSTRUMENTATION  IN  THE  JOURNALS   "NATURE"  AND  "SCIENCE"  FOR  2001–2017.   WEBOMETRIC  ANALYSIS

Background: Captopril is the synthetic dipeptide used as an angiotensin converting enzyme inhibitor. Captopril is used to treat hypertension as well as for the treatment of moderate heart failure. Analytical instrumentation and methodology plays an important role in pharmaceutical analysis. Methods: This review presents some important applications of electrochemical modes used for the analysis of captopril. So far captopril has been analyzed by using different bare and modified working electrodes with a variety of modifiers from organic and inorganic materials to various types of nano particles/materials. Results: This paper presents some of the methods which have been published in the last few years i.e. from 2003 to 2016. This review highlights the role of the analytical instrumentation, particularly electrochemical methods in assessing captopril using various working electrodes. Conclusion: A large number of studies on voltammetry noted by means of various bare and modified electrodes. Among all of the published voltammetric methods, DPV, SWV, CV and miscellaneous modes were trendy techniques used to analyze captopril in pharmaceutical formulations as well as biological samples. Electrodes modified with nanomaterials are promising sensing tools as this showed high sensitivity, good accuracy with precision as well as selectivity. In comparison to chromatographic methods, the main advantages of electrochemical methods are its cheaper instrumentation, lower detection limit and minimal or no sample preparation.

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Jarrell Ash ANALYTICAL INSTRUMENTATION

Analytical Chemistry ◽

10.1021/ac60236a735 ◽

1966 ◽

Vol 38 (04) ◽

pp. 46A-46A

Keyword(s):

Analytical Instrumentation

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Evaluation of analytical instrumentation. Part V. Inductively coupled plasma sources for use in emission spectrometry

Analytical Proceedings ◽

10.1039/ap9872400266 ◽

1987 ◽

Vol 24 (9) ◽

pp. 266 ◽

Cited By ~ 1

Keyword(s):

Inductively Coupled Plasma ◽

Emission Spectrometry ◽

Plasma Sources ◽

Inductively Coupled ◽

Analytical Instrumentation

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Recent Advances in Discovery of Lead Structures from Microbial Natural Products: Genomics- and Metabolomics-Guided Acceleration

Molecules ◽

10.3390/molecules26092542 ◽

2021 ◽

Vol 26 (9) ◽

pp. 2542

Author(s):

Linda Sukmarini

Keyword(s):

Natural Products ◽

Genome Mining ◽

Screening Methods ◽

Technological Advancement ◽

Natural Origin ◽

Drug Discovery And Development ◽

New Methodologies ◽

Analytical Instrumentation ◽

Microbial Natural Products ◽

Drug Leads

Natural products (NPs) are evolutionarily optimized as drug-like molecules and remain the most consistently successful source of drugs and drug leads. They offer major opportunities for finding novel lead structures that are active against a broad spectrum of assay targets, particularly those from secondary metabolites of microbial origin. Due to traditional discovery approaches’ limitations relying on untargeted screening methods, there is a growing trend to employ unconventional secondary metabolomics techniques. Aided by the more in-depth understanding of different biosynthetic pathways and the technological advancement in analytical instrumentation, the development of new methodologies provides an alternative that can accelerate discoveries of new lead-structures of natural origin. This present mini-review briefly discusses selected examples regarding advancements in bioinformatics and genomics (focusing on genome mining and metagenomics approaches), as well as bioanalytics (mass-spectrometry) towards the microbial NPs-based drug discovery and development. The selected recent discoveries from 2015 to 2020 are featured herein.

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