RELATIVE POTENCIES OF MOTOR BLOCKADE AFTER INTRATHECAL ROPIVACAINE, LEVOBUPIVACAINE AND BUPIVACAINE

SummaryThree mucopolysaccharides (MPS) used in the treatment of degenerative joint disease were compared to heparin to establish their relative potencies on 3 coagulation tests, the aPTT, the antifactor X a activity and the dilute thrombin time. One of the compounds, Arteparon®, was one fourth as potent as heparin on the aPTT, but had little or no influence on the 2 other tests. Further in vitro studies suggested that Arteparon® acted at a higher level than factor Xa generation in the intrinsic amplification system and that its effect was independent of antithrombin III. In vivo administration of Arteparon® confirmed its anticoagulant properties, which raises the question of the clinical use of this MPS.

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COMPARATIVE ACTION OF VARIOUS OESTROGENIC COMPOUNDS ON MOUSE VAGINAL SIALIC ACIDS (II)

Acta Endocrinologica ◽

10.1530/acta.0.0620663 ◽

1969 ◽

Vol 62 (4) ◽

pp. 663-670 ◽

Cited By ~ 8

Author(s):

Lars Carlborg

Keyword(s):

Sialic Acid ◽

Response Curve ◽

Sialic Acids ◽

Clear Cut ◽

Suitable Parameter ◽

Sufficient Degree ◽

Comparative Action ◽

Relative Potencies ◽

Good Agreement

ABSTRACT Oestrogens administered in lower doses than necessary to induce full cornification of the mouse vagina induce mucification. It was shown previously that the degree of mucification could be estimated by quantitative determination of sialic acids. A suitable parameter for oestrogen assay was the measurement of vaginal sialic acid concentration which exhibited a clear cut dose response curve. Eleven assays of various oestrogens were performed with this method. Their estimated relative potencies were in good agreement with other routine oestrogen assays. A statistically sufficient degree of precision was found. The sensitivity was of the same order, or slightly higher, than the Allen-Doisy test.

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HUMAN URINARY GONADOTROPHINS ASSAYED BY DIFFERENT RESPONSES IN THE SAME ANIMAL

Acta Endocrinologica ◽

10.1530/acta.0.xxxiv0375 ◽

1960 ◽

Vol XXXIV (III) ◽

pp. 375-389 ◽

Cited By ~ 1

Author(s):

P. S. Brown

Keyword(s):

Postmenopausal Women ◽

Ovarian Response ◽

The Other ◽

Relative Potency ◽

Vaginal Opening ◽

Serial Sections ◽

Immature Female ◽

Female Mice ◽

Marked Disparity ◽

Relative Potencies

ABSTRACT Selected human urinary gonadotrophins were assayed against one another using various measures of response in the same immature female mice. Intact or hypophysectomized animals were used and in some experiments the results of hypophysectomy were checked in complete serial sections. Extracts from the urine of two subjects with Turner's syndrome were compared. In intact mice, the relative potency judged by the ovarian response differed from that shown by the uterine response and the 95 % fiducial limits of the two estimates did not overlap. When the mice were hypophysectomized, one extract became much less potent while the other did not. Similar differences were shown in the response of intact mice to urinary extracts from two subjects with Klinefelter's syndrome. There was a marked disparity between the relative potencies shown by the uterine response and by the incidence of vaginal opening. Similar differences were not shown between the responses to different extracts from the urine of normal postmenopausal women, but these extracts were known to differ little in quality. The results are interpreted in terms of qualitative differences between human urinary gonadotrophins.

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Faculty Opinions recommendation of Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732609567.793542924 ◽

2018 ◽

Author(s):

Margaret Sedensky ◽

Pavel Zimin

Keyword(s):

Drosophila Melanogaster ◽

Genetic Variability ◽

Kinetics Of ◽

Relative Potencies

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Effects of summer mailing on in vivo and in vitro relative potencies of standardized timothy grass extract

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2009.11.037 ◽

2010 ◽

Vol 104 (2) ◽

pp. 147-151 ◽

Cited By ~ 5

Author(s):

Meredith Moore ◽

Mark Tucker ◽

Tom Grier ◽

James Quinn

Keyword(s):

Timothy Grass ◽

Relative Potencies

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A comparative study between the effect of verapamil versus nalbuphine as an adjuvant in supraclavicular brachial plexus block

Ain-Shams Journal of Anesthesiology ◽

10.1186/s42077-021-00149-3 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Mohammed Ibrahim Khamis ◽

Ahmed Saeed Mohamed ◽

Hesham Mohamed El Azazy ◽

Hala Salah El Ozairy ◽

Mohamed Moien Mohamed

Keyword(s):

Comparative Study ◽

Brachial Plexus ◽

Normal Saline ◽

Motor Block ◽

Brachial Plexus Block ◽

Sensory Block ◽

Motor Blockade ◽

Group A ◽

Group B ◽

Plexus Block

Abstract Background Brachial plexus block has substituted general anesthesia in the majority of patients planned for upper limb surgeries as it avoids the undesired effects of the medications used in general anesthesia as well as the stress response associated with airway manipulation. Opioid agonist–antagonists such as nalbuphine are used as adjuvant to improve the anesthetic properties of bupivacaine. Verapamil has an additive effect in brachial plexus blockade in the form of decreasing the consumption of analgesics in the postoperative period with reducing onset time and extending the duration of motor and sensory blockade. The aim of this study is to investigate the adjuvant effect of verapamil versus nalbuphine to 0.5% bupivacaine in brachial plexus block as regards onset, duration of sensory and motor blockade and postoperative analgesic augmentation. The study is randomized, prospective, double-blinded, comparative study where 90 patients subjected to arm, forearm and hand surgeries were randomized into three groups, group A received 30 ml of plain bupivacaine 0.5% plus 2 ml of normal saline, group B received 30 ml of bupivacaine 0.5% plus 2 ml verapamil equivalent to 5 mg, group C received 30 ml of bupivacaine 0.5% plus 10 mg of nalbuphine diluted in 2 ml of normal saline. Results Results of this study showed that group C and group B sensory block time onset was 7.25 ± 1.5 vs. 10.92 ± 3.84 min, P < 0.001 and was shorter than that in group A (13.2 ± 2.66 min). In addition, the motor block onset was (11.10 ± 1.24 vs. 13.50 ± 3.77 min, P < 0.001) shorter than group A (17.16 ± 1.30 min). In group C and group B, sensory block duration was 396 ± 32.17 vs. 355.83 ± 18.48 min, P < 0.001, respectively and was longer than that in group A (321.13 ± 25.08 min). Also, there was prolonged motor block duration in group C and group B recording (338.92 ± 25.2 vs. 302.93 ± 15.24 min, P < 0.001) and was longer than that in group A (280.70 ± 32.35 min). Time of demand of rescue analgesia dose was significantly long in group C and group B (449.53 ± 52.45 vs. 418.13 ± 41.12 min, P < 0.001) and was longer than group A (361.31 ± 21.42 min). Both verapamil and nalbuphine have additive effect to bupivacaine improving the all anesthetic parameters of the block. Conclusion Both drugs produce favorable enhancement of time onset and effective prolongation of duration of sensory and motor blockade and extend the period of postoperative analgesia with superiority to nalbuphine over verapamil.

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COMPARATIVE EFFECTS OF THE OESTROGENS AND OTHER STEROID HORMONES ON SERUM LIPIDS AND PROTEINS IN XENOPUS LAEVIS DAUDIN

Journal of Endocrinology ◽

10.1677/joe.0.0430047 ◽

1969 ◽

Vol 43 (1) ◽

pp. 47-53 ◽

Cited By ~ 41

Author(s):

M. R. REDSHAW ◽

B. K. FOLLETT ◽

T. J. NICHOLLS

Keyword(s):

Plasma Concentration ◽

Xenopus Laevis ◽

Steroid Hormones ◽

South African ◽

Calcium Binding ◽

Serum Lipids ◽

Response Curves ◽

Yolk Formation ◽

Log Linear ◽

Relative Potencies

SUMMARY A comparison has been made between the effects of oestradiol-17β, oestrone, oestriol, progesterone, testosterone and cortisone on the plasma concentration of proteins and lipids in the South African clawed toad, Xenopus laevis Daudin. No major changes in the parameters studied were found with the non-oestrogenic steroids; only the three oestrogens induced the appearance in the plasma of a calcium-binding phospholipoprotein and esterified lipids associated with yolk formation. These results support the hypothesis that the oestrogens alone cause the vitellogenic response in oviparous vertebrates. Dose—response curves for oestradiol-17β, oestrone and oestriol were established for the effects on plasma protein, calcium, protein-bound phosphorus, phospholipid, lipid and cholesterol. The curves obtained were log.-linear over the range of doses employed (oestradiol-17β, 1–50 μg./day; oestrone, 4–100 μg./day; oestriol, 20–500 μg./day) with the exception of the cholesterol response to oestradiol. The relative potencies of the three oestrogens were compared for each of the plasma components measured. Oestradiol-17β was the most potent, being 3·9 times more active than oestrone and 13·7 times more active than oestriol.

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