scholarly journals Using rDCM Method in the Mixed Model in order to Inference Effective Connectivity in Emotions

Author(s):  
Naemeh Farahani ◽  
Emad Fatemizadeh ◽  
Ali Motie Nasrabadi

Purpose: Recently, data from functional magnetic resonance imaging in the field of neuroscience have been strongly considered for the modeling of cognitive activities. Therefore, the use of a suitable method is important for evaluating functional magnetic resonance imaging data. Regression dynamic causal modeling is introduced as a new version of dynamic causal modeling in order to extract and derive effective connectivity in functional magnetic resonance imaging data. We used this method to investigate the distinction between effective connectivity and the pair of emotional states. Materials and Methods: In this article, the effective connectivity between regions and activity of brain regions of interest during the application of a particular type of stimulation, which simulates the emotions created during human life, is examined in the form of an audio-movie. To do this, we applied the regression dynamic causal modeling method to a network consisting of 18 regions of interest that named the mixed model. Results: In the mixed model, the distinction between happiness-anger, happiness-fear, and happiness-love was more intense. Finally, significant effective connectivities were observed in the auditory regions and regions related to emotion processing. Conclusion: Ultimately, we could represent the distinction between emotions by applying the regression dynamic causal modeling to the mixed model.

2021 ◽  
Vol 15 ◽  
Author(s):  
Andrew D. Snyder ◽  
Liangsuo Ma ◽  
Joel L. Steinberg ◽  
Kyle Woisard ◽  
Frederick G. Moeller

Dynamic causal modeling (DCM) is a method for analyzing functional magnetic resonance imaging (fMRI) and other functional neuroimaging data that provides information about directionality of connectivity between brain regions. A review of the neuropsychiatric fMRI DCM literature suggests that there may be a historical trend to under-report self-connectivity (within brain regions) compared to between brain region connectivity findings. These findings are an integral part of the neurologic model represented by DCM and serve an important neurobiological function in regulating excitatory and inhibitory activity between regions. We reviewed the literature on the topic as well as the past 13 years of available neuropsychiatric DCM literature to find an increasing (but still, perhaps, and inadequate) trend in reporting these results. The focus of this review is fMRI as the majority of published DCM studies utilized fMRI and the interpretation of the self-connectivity findings may vary across imaging methodologies. About 25% of articles published between 2007 and 2019 made any mention of self-connectivity findings. We recommend increased attention toward the inclusion and interpretation of self-connectivity findings in DCM analyses in the neuropsychiatric literature, particularly in forthcoming effective connectivity studies of substance use disorders.


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