scholarly journals To Study Effectiveness of Nasal Prong and Nasal Mask in Nasal Continuous Positive Airway Pressure in Preterm Neonates with Respiratory Distress

2017 ◽  
Vol 05 (05) ◽  
pp. 21409-21415 ◽  
Author(s):  
Dr Gaurav Kumar ◽  
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Respiratory Distress ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Preterm Neonates ◽  
Nasal Mask ◽  
Nasal Prong

scholarly journals Study on therapeutic effectiveness of continuous positive airway pressure compared to mechanical ventilation in preterm babies with respiratory distress

2019 ◽  
Vol 6 (4) ◽  
pp. 1476
Author(s):  
Kirankumar Harwalkar ◽  
Babalala Kadegaon
Keyword(s):  
Mechanical Ventilation ◽  
Continuous Positive Airway Pressure ◽  
Respiratory Distress ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Preterm Neonates ◽  
P Value ◽  
Therapeutic Effects ◽  
Cpap Treatment ◽  
Preterm Babies

Background: Previously mechanical ventilation was primary modality of treatment in preterm neonates with respiratory distress. With the introduction of continuous positive airway pressure (CPAP), the need of mechanical ventilation is reduced. The present study was done to know the therapeutic effects of CPAP as compared to mechanical ventilation in preterm neonates with respiratory distress. To study the duration of oxygen requirement and duration of hospitalisation in preterm neonates treated with CPAP compared to invasive mechanical ventilationMethods: Hospital based prospective study was conducted from November 2013 to November 2014 in Dr. B. R. Ambedkar medical college, Bangalore. All the preterm babies admitted in neonatal intensive care unit with respiratory distress requiring CPAP or mechanical ventilation during study period were included. Total 50 cases were included, out of which 20 (40%) were on CPAP treatment and 30 (60%) were on mechanical ventilation. Outcome was assessed by reduction of respiratory distress with SpO2 more than 88% with FiO2 of 21%.Results: Out of 50 preterm neonates studied, 20 (40%) were on CPAP treatment and 30 (60%) were on mechanical ventilation. Mean duration of oxygen treatment was less in neonates on CPAP (4.8±0.9 days) compared to mechanical ventilated neonates (7.12±0.8days) and it is statistically significant (p value<0.05). Mean duration of hospitalisation was less in neonates on CPAP (19.3±0.76 days) compared to mechanical ventilated neonates (21±1.2 days) but it was statistically not significant (P value >0.05).Conclusions: CPAP as a mode of treatment for preterm babies with respiratory distress reduces the duration of oxygen dependency compared to invasive mechanical ventilation. Difference in duration of hospital stay was statistically not significant in these neonates treated with CPAP and mechanical ventilation.

scholarly journals Personalized Medicine for the Management of RDS in Preterm Neonates

Neonatology ◽  
2021 ◽  
pp. 1-12
Author(s):  
Daniele De Luca ◽  
Chiara Autilio ◽  
Lucilla Pezza ◽  
Shivani Shankar-Aguilera ◽  
David G. Tingay ◽  
...  
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Respiratory Distress Syndrome ◽  
Diagnostic Accuracy ◽  
Respiratory Distress ◽  
Airway Pressure ◽  
Industrial Development ◽  
Distress Syndrome ◽  
Lung Ultrasound ◽  
Positive Airway Pressure ◽  
Preterm Neonates

Continuous positive airway pressure and surfactant represent the first- and second-line treatment for respiratory distress syndrome in preterm neonates, as European and American guidelines, since 2013 and 2014, respectively, started to recommend surfactant replacement only when continuous positive airway pressure fails. These recommendations, however, are not personalized to the individual physiopathology. Simple clinical algorithms may have improved the diffusion of neonatal care, but complex medical issues can hardly be addressed with simple solutions. The treatment of respiratory distress syndrome is a complex matter and can be only optimized with personalization. We performed a review of tools to individualize the management of respiratory distress syndrome based on physiopathology and actual patients’ need, according to precision medicine principles. Advanced oxygenation metrics, lung ultrasound, electrical impedance tomography, and both quantitative and qualitative surfactant assays were examined. When these techniques were investigated with diagnostic accuracy studies, reliability measures have been meta-analysed. Amongst all these tools, quantitative lung ultrasound seems the more developed for the widespread use and has a higher diagnostic accuracy (meta-analytical AUC = 0.952 [95% CI: 0.951–0.953]). Surfactant adsorption (AUC = 0.840 [95% CI: 0.824–0.856]) and stable microbubble test (AUC = 0.800 [95% CI: 0.788–0.812]) also have good reliability, but need further industrial development. We advocate for a more accurate characterization and a personalized approach of respiratory distress syndrome. With the above-described currently available tools, it should be possible to personalize the treatment of respiratory distress syndrome according to physiopathol­ogy.

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