scholarly journals Measurement of Serum Amylase in Correlation with Plasma Cholinesterase Level for Assessing the Severity of Organophosphorus Poisoning

2019 ◽  
Vol 7 (3) ◽  
Author(s):  
Dr M. Ramesh MD
Keyword(s):  
Serum Amylase ◽  
Plasma Cholinesterase ◽  
Organophosphorus Poisoning

Plasma cholinesterase: double-edged parameter in the diagnosis of acute organophosphorus poisoning

2010 ◽  
Vol 50 (3) ◽  
pp. 159-160 ◽  
Author(s):  
D R Mahadeshwara Prasad ◽  
Hareesh S Gouda ◽  
Vinay R Hallikeri
Keyword(s):  
Biochemical Marker ◽  
Organophosphorus Pesticides ◽  
Clinical Signs ◽  
Organophosphorus Pesticide ◽  
Signs And Symptoms ◽  
Acute Poisoning ◽  
Plasma Cholinesterase ◽  
Pesticide Poisoning ◽  
Organophosphorus Poisoning ◽  
Clinical Signs And Symptoms

Biochemical markers are one of the mainstays in the diagnosis of ill health. Plasma cholinesterase is one such marker of the ill health caused by acute organophosphorus pesticide poisoning. Organophosphorus pesticides are powerful inhibitors of plasma cholinesterase; consequently, the reduced level of this biochemical marker has been used in the diagnosis of cases of acute poisoning. But how dependable is this biochemical marker in the diagnosis of suspected organophosphorus pesticide poisoning without adequate clinical signs and symptoms? In the case reported here, the low level of plasma cholinesterase which was suspected to be due to organophosphorus poisoning was found to be caused by pulmonary Koch's and hepatitis B with associated malnutrition.

scholarly journals Kinetic Study on the Recovery of Plasma Cholinesterase and Erythrocyte Acethylcholinesterase Activities after Organophosphorus Poisoning in Humans.

1991 ◽  
Vol 2 (3) ◽  
pp. 621-629
Author(s):  
Yoichi Shirakawa ◽  
Ikuko Tsukamoto ◽  
Keisuke Seki ◽  
Mayuki Aibiki ◽  
Kiyoshi Ameno
Keyword(s):  
Kinetic Study ◽  
Plasma Cholinesterase ◽  
Organophosphorus Poisoning

scholarly journals Study of Serum Amylase for Predicting the Severity of Organophosphorus Poisoning and Correlation with Respiratory Failure - A Cross Sectional Study at KIMS, Hubballi, Karnataka

2021 ◽  
Vol 8 (20) ◽  
pp. 1473-1478
Author(s):  
Raghu Gangadharappa ◽  
Manojkumar B. Kalegowda ◽  
Bharath Golla
Keyword(s):  
Respiratory Failure ◽  
Serum Amylase ◽  
Financial Burden ◽  
Limited Resource ◽  
Biochemical Parameter ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Mean Values ◽  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

BACKGROUND Organophosphorus (OP) compounds are insecticides which are widely used in agriculture. Acute organophosphorus poisoning is one of the important causes of morbidity and mortality in developing countries like India. Considering financial burden / availability of tests, we need cheap and easily measurable biomarkers for predicting prognosis / complications in a limited resource country, like India. We intend to correlate the levels of serum amylase in patients admitted with acute organophosphorus poisoning for predicting the severity of acute OP poisoning and also to correlate serum amylase association with respiratory failure. METHODS This was a prospective observational study. Total of 94 patients of OP poisoning admitted to KIMS Hospital, Hubballi between January 1st 2017 and December 31th 2017 were studied. Detailed history, clinical examination, and lab investigations like pseudocholinesterase, serum amylase and other relevant investigations were carried out. Peradeniya OP poisoning scale was applied to all the study subjects and the severity of OP poisoning was graded as mild, moderate, severe. Data obtained was analysed by different statistical methods. RESULTS OP poisoning was more common in adults of age group between 20 – 30 years, Incidence was more in male patients and mortality rate was 12.8 %. Mean values of serum amylase negatively correlate with pseudocholinesterase levels and it was statistically significant. Correlation between the severity of OP poisoning (based on Peradeniya score) and biochemical parameters like pseudocholinesterase, serum amylase was statistically significant. CONCLUSIONS The correlation between the severity of OP poisoning and biochemical parameter– serum amylase, was statistically significant and it was useful in predicting the development of respiratory failure. Pseudocholinesterase and serum amylase were also useful to predict the outcome of the patient. KEYWORDS Amylase, Organophosphorus Poisoning, Pseudocholinesterase, Peradeniya Score

scholarly journals SERUM AMYLASE AS A BIOCHEMICAL MARKER TO PREDICT THE CLINICAL OUTCOME IN ORGANOPHOSPHORUS POISONING

2018 ◽  
Vol 5 (49) ◽  
pp. 3354-3357
Author(s):  
John Vinoj ◽  
Gogul Gogul ◽  
Shanmughasundaram Shanmughasundaram ◽  
Pooja Pooja
Keyword(s):  
Clinical Outcome ◽  
Serum Amylase ◽  
Biochemical Marker ◽  
Organophosphorus Poisoning

Role of Plasma Cholinesterase level in Assessment of Severity and Outcome in Organophosphorus Poisoning

2021 ◽  
Vol 19 (1and2) ◽  
pp. 23-26
Author(s):  
Mustaria Pankaj Kumar Shushil ◽  
Nirmal Arya ◽  
Mukesh Kumar Bansal ◽  
Ajay Agarwal
Keyword(s):  
Plasma Cholinesterase ◽  
Organophosphorus Poisoning

scholarly journals Clinical significance of serum amylase and glucose level in organophosphorus poisoning

2019 ◽  
Vol 2 (3) ◽  
pp. 121-125
Author(s):  
Manoj Koirala ◽  
Bishow Raj Baral ◽  
Buddhisagar Lamichanne
Keyword(s):  
Acute Pancreatitis ◽  
Glucose Level ◽  
Serum Amylase ◽  
Serum Glucose ◽  
Clinical Severity ◽  
Serum Glucose Level ◽  
Amylase Level ◽  
Serum Amylase Level ◽  
Organophosphorus Poisoning ◽  
The Mean

Background: Organophosphorous (OP) poisoning is a common problem in country like Nepal where agriculture is the backbone of the economy. The primary mechanism of action is inhibition of acetylcholinesterase (ACHE). Organophosphorus poisoning is a possible cause of acute pancreatitis along with alternation of glucose metabolism. Materials and Method: This was a hospital based cross-sectional comparative study. The level of serum amylase and glucose were measured in thirty-eight OP poisoned patients at the time of admission, before discharge and were compared. Results: Amongst 38 patients, Majority had mild OP poisoning 27(71.1%) as per Peradeniya Organophosphorus Poisoning (POP) score whereas 9(23.7%) had moderate and 2(5.2%) had severe poisoning. The mean initial serum amylase level in patients with mild poisoning was 152±73.92 (IU/L)(p=0.000), in moderate poisoning was 213.38±69.39 (IU/L) (p=0.223) and in severe poisoning was 171.33±107.22(IU/L) (p=0.259). There was increase in serum amylase level in all patients with poisoning but level did not increase in proportion to increase with severity of POP score. The mean initial serum glucose level in mild poisoning was 132.48±37.73 (Mg/dl) (p=0.024), in moderate poisoning was 139±44.59 (Mg/dl) (p=0.033) and in severe poisoning was 174±23.38 (Mg/dl) (p=0.22). The serum glucose level increased as the severity of POP score increased. The serum amylase and glucose levels in recovering patients showed a tendency to decrease to their normal values. No patient had developed acute symptomatic pancreatitis. Conclusion: Serum amylase and glucose level were increased in all patients with OP poisoning but didn’t correlate with the clinical severity. Routine measurement of serum amylase in patients of OP poisoning has little value in the absence of clinical acute pancreatitis.

scholarly journals Correlation of Serum Amylase, Lipase and Creatine Kinase with Severity of Organophosphate Poisoning- A Cohort Study

2021 ◽  
Author(s):  
Noas Tobias Minz ◽  
Sarat Chansra Singh ◽  
Priyabrata Jena ◽  
Pranay Kumar Patro
Keyword(s):  
Creatine Kinase ◽  
Cohort Study ◽  
Rural Areas ◽  
Serum Amylase ◽  
Hospital Admissions ◽  
Acetylcholine Esterase ◽  
Serum Cholinesterase ◽  
Organophosphate Poisoning ◽  
Mean Values ◽  
Organophosphorus Poisoning

Introduction: Organophosphate Compounds (OP) are widely used pesticides in agriculture. It is easily available and OP poisoning is most common cause of poisoning and hospital admissions. Severe poisoning is associated with high mortality. Severity of poisoning can be assessed by Peradeniya Organophosphorus Poisoning (POP) scale, Acute Physiology and chronic Health Evaluation (APACHE) II, Glasgow Coma Scale (GCS) or serum Cholinesterase Level (ChE). Serum amylase, lipase, and creatine kinase are important biomarkers raised in OP poisoning. Aim: To correlate serum amylase, lipase, and creatine kinase with severity of OP poisoning. Materials and Methods: This was a hospital based observational cohort study conducted on 130 patients of organophosphate poisoning admitted in General Medicine wards of SCB Medical College, Cuttack, Odisha from June 2019 to December 2020. Serum Acetylcholine Esterase (AChE), amylase, lipase and creatinine kinase were estimated at admission, day 2, and at discharge. Other routine investigations were done. Acetylcholine Esterase (AChE) was used to confirm the diagnosis. The severity of poisoning was assessed using POP scale and graded as mild, moderate and severe. The severity of poisoning and the level of enzymes were correlated. The parameters were tabulated and mean values and Standard Deviation (SD) were analysed using Statistical Package For The Social Sciences (SPSS) software version 22.0. Results: Out of 130 patients 91 were males and 39 were females, mostly from rural areas, both farming and non-farming community. Age ranged from 14 years to 79 years, with majority in 19 to 39 years. AChE decreased in all cases depending on severity confirming OP poisoning. Severity as assessed by POP score were mild (52 patients), moderate (46 patients) and severe (32 patients). At admission, the Amylase (U/L), Lipase (U/L), and Creatine kinase (U/L) level (mean±SD) in mild poisoning were 83.7±41.9 U, 70.9±18.6, 72.5±34.9, in moderate poisoning 153.6±109.7, 91.9±47.4, 92.6±81.5, and in severe poisoning 243.9±113.8, 195.3±147.7, 298.8±207.4, respectively. Measurements on second day also remained elevated. Among the severe cases 24 patients developed Intermediate Syndrome (IMS), and 26 patients died. There was positive correlation between increase of enzyme levels and the severity of OP poisoning as per POP score. Conclusion: Serum amylase, lipase, and creatine kinase level correlated well with the severity of organophosphorus poisoning and scan be used additionally as an indicator to assess the severity. Serum amylase is a better indicator of severity than lipase and Creatine Kinase (CPK).

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