scholarly journals Simultaneous Spectrophotometric Estimation of Enalapril Maleate and Losartan Potassium in Tablet Dosage form and It's Application to Dissolution Study

2009 ◽  
Vol 8 (2) ◽  
pp. 85
Author(s):  
A. B. Thomas ◽  
A. A. Chaudhari ◽  
R. K. Nanda ◽  
L. P. Kothapalli ◽  
U. B. Chavan ◽  
...  
Keyword(s):  
Dosage Form ◽  
Losartan Potassium ◽  
Enalapril Maleate ◽  
Dissolution Study ◽  
Tablet Dosage

scholarly journals Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Hydrochlorothiazide and Losartan Potassium in Tablet Dosage Form

2012 ◽  
Vol 10 (1) ◽  
pp. 35-42
Author(s):  
Md Arif Hossen ◽  
Md Ahsanul Haque ◽  
Irin Dewan ◽  
ANM Hamidul Kabir ◽  
Md Khalid Hossain ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Dosage Form ◽  
Hplc Method ◽  
Phosphoric Acid Solution ◽  
Losartan Potassium ◽  
Simultaneous Estimation ◽  
Uv Detector ◽  
Rp Hplc ◽  
Efficient Option ◽  
Tablet Dosage

In the present study, a simple, sensitive and specific liquid chromatography (RP-HPLC) method has been developed and validated for the quantification of hydrochlorothiazide and losartan potassium in tablet dosage form. A shim-pack CLC-ODS column (250 mm X 4.6 mm, 5μ and a mobile phase constituting 0.025 M phosphoric acid solution: acetonitrile (60:40 v/v, pH 3.0 adjusted with 80% phosphoric acid) were used. The flow rate was 1.5 ml/min and detection was carried by using ultraviolet (UV) detector at a wavelength of 254 nm. The retention times of hydrochlorothiazide and losartan potassium were 3.748 min and 8.790 min, respectively. The peaks of hydrochlorothiazide and losartan potassium were well separated (resolution 22.17). The calibration curves were linear over the concentration range of 80% to 120% (R2 > 0.999 for both the drugs). The proposed method is accurate with 100.165% recovery for hydrochlorothiazide and 100.422% recovery for losartan potassium and precise (% RSD < 0.5). The proposed method was successfully applied for the estimation of hydrochlorothiazide and losartan potassium in market products (three brands) and potency was found within limit. Therefore, this method can be a convenient and efficient option for the analysis of hydrochlorothiazide and losartan potassium in tablet dosage form. DOI: http://dx.doi.org/10.3329/dujps.v10i1.10013 DUJPS 2011; 10(1): 35-42

scholarly journals METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LAMIVUDINE, DOLUTEGRAVIR AND TENOFOVIR DISOPROXIL FUMARATE IN BULK AND PHARMACEUTICAL DOSAGE FORM USING RP-HPLC AND ITS APPLICATION TO IN-VITRO DISSOLUTION STUDY

2021 ◽  
Vol 10 (4) ◽  
pp. 3202-3207
Author(s):  
K. Nihila
Keyword(s):  
Tenofovir Disoproxil Fumarate ◽  
Dosage Form ◽  
Method Development ◽  
In Vitro Dissolution ◽  
Simultaneous Estimation ◽  
Pharmaceutical Dosage Form ◽  
Dissolution Study ◽  
Rp Hplc ◽  
Tablet Dosage

A simple, rapid, and economical method has been developed for the simultaneous estimation of the latest FDA approved antiviral drug combination, Dolutegravir, Lamivudine, and tenofovir disoproxil fumarate in tablet dosage form using Shimadzu LC-20 AT HPLC with a Phenomenex Luna column compartment., the method was developed using HPLC graded methanol with o-phosphoric acid as a mobile phase and successfully validated the developed method as per the ICH guidelines. The method was found to be linear, accurate, precise, robust, and rugged. The limit of detection and the limit of quantification was found to be 2.6μg/ml and 8.18μg/ml for Dolutegravir, 14.63 μg/ml and 44.35 μg/ml for Lamivudine and 16.43 μg/ml and 49.81 μg/ml for tenofovir disoproxil fumarate respectively. The retention time was found to be 3.0, 2.3 and 2.7 min for Dolutegravir, Lamivudine and tenofovir disoproxil fumarate respectively. All of assessed parameters complied with the acceptance criteria hence indicated the usefulness of the RP-HPLC method for the determination of assay and in-vitro dissolution study for tablet dosage form which contains lamivudine, tenofovir disoproxil fumarate, and dolutegravir active substances. Hence the method can be applied for routine quality control of the drugs.

scholarly journals A method for content uniformity determination of atenolol and losartan potassium in combined tablet dosage form

2010 ◽  
Vol 72 (6) ◽  
pp. 792 ◽  
Author(s):  
RB Vyas ◽  
NR Maniyar ◽  
DR Shah ◽  
SA Shah ◽  
BA Vyas ◽  
...  
Keyword(s):  
Dosage Form ◽  
Losartan Potassium ◽  
Content Uniformity ◽  
Tablet Dosage

scholarly journals Simultaneous Spectrophotometric Estimation of Hydrochlorothiazide, Atenolol and Losartan Potassium in Tablet Dosage Form

2009 ◽  
Vol 8 (3) ◽  
pp. 139
Author(s):  
A. B. Thomas ◽  
U. B. Chavan ◽  
R. K. Nanda ◽  
L. P. Kothapalli ◽  
A. D. Deshpande
Keyword(s):  
Dosage Form ◽  
Losartan Potassium ◽  
Tablet Dosage

Novel UV Spectrophotometric Method for the Quantitative Analysis of CefpodoximeProxetil in Pharmaceutical Formulations by First Derivative Technique

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Potdar S. S. ◽  
Karajgi S. R. ◽  
Simpi C. C. ◽  
Kalyane N. V.
Keyword(s):  
Quantitative Analysis ◽  
Spectrophotometric Method ◽  
Dosage Form ◽  
Pharmaceutical Formulations ◽  
First Derivative ◽  
Good Linearity ◽  
Beer's Law ◽  
Beer’S Law ◽  
Tablet Dosage ◽  
Ich Guideline

The spectrophotometric method for estimation of CefpodoximeProxetil employed first derivative amplitude UV spectrophotometric method for analysis using methanol as solvent for the drug. CefpodoximeProxetil has absorbance maxima at 235nm and obeys Beer’s law in concentration range 10-50µg/ml with good linearity i.e. r2 about 0.999. The recovery studies established accuracy of the proposed method; result validated according to ICH guideline. Results were found satisfactory and reproducible. The method was successfully for evaluation of CefpodoximeProxetil in tablet dosage form without interference of common excipients.

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