The Performance of Glycated Hemoglobin vs. Oral Glucose Tolerance Test in the Diagnosis of Glycemic Disorders among Women with Polycystic Ovary Syndrome in Southern Iraq

BACKGROUND: Obese women with polycystic ovary syndrome (PCOS) are at high risk for developing type 2 diabetes mellitus (T2DM). A baseline oral glucose tolerance test (2-h OGTT) is important to screen for dysglycemia in PCOS particularly those high risk women. Due to its advantages by fasting is not required and less day-to-day variability, glycated hemoglobin (HbA1c) might be a convenient screening tool. This study aimed to evaluate the performance of HbA1c vs. 2-h OGTT in the diagnosis of glycemic disorders in PCOS and to evaluate the correlation between glycemic disorders, insulin resistance (IR), and anthropometric measures.METHODS: One hundred and twenty nine women diagnosed with PCOS according to the Rotterdam 2003 criteria in Basrah were included in the study. All subjects were examined for weight, body mass index (BMI) and waist circumference (WC). Then they were tested for fasting glucose, 2-h OGTT, HbA1c, and fasting insulin to assess IR.RESULTS: The result of 2-h OGTT test showed that there were 21 subjects (16.1%) showed to have IGT. The result of HbA1c test showed that 25 subjects (19.4%) were diagonised with prediabetes. Meanwhile FPG test result showed that 34 subjects (26.4%) were having IFG. The HbA1c examination showed an underdetected the diagnosis of T2DM (0.8%) and an overdeteced diagnosis of prediabetes (19.4%) (p=0.021) and at HbA1c 5.55% (37.2 mmol/mol), the specificity was (74.3%) and sensitivity (56.5%) to discriminate normal from abnormal glucose status. Ninety nine women (76.7%) were either overweight or obese and most of them had IR (76.8%).CONCLUSION: Screening of glycemic disorders is crucial for PCOS by using 2-h OGTT regardless of risk factor and HbA1c seems to be an unsatisfactory screening tool to predict glycemic disorders in women with PCOS.KEYWORDS: PCOS, glycemic disorders, OGTT, HbA1c, insulin resistance, and prediabetes

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Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: A significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2004.12.014 ◽

2005 ◽

Vol 85 (1) ◽

pp. 61-69 ◽

Cited By ~ 36

Author(s):

Krzysztof C. Lewandowski ◽

Konrad Szosland ◽

Chris O’Callaghan ◽

Bee K. Tan ◽

Harpal S. Randeva ◽

...

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Glucose Tolerance ◽

Glucose Tolerance Test ◽

Polycystic Ovary ◽

Serum Levels ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Ovary Syndrome

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Surrogate markers of insulin resistance obtained from oral glucose tolerance test in different phenotypes of polycystic ovary syndrome

Endocrine Abstracts ◽

10.1530/endoabs.37.ep133 ◽

2015 ◽

Author(s):

Ivana Bozic Antic ◽

Jelica Bjekic-Macut ◽

Danijela Vojnovic Milutinovic ◽

Dusan Ilic ◽

Bojana Popovic ◽

...

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Glucose Tolerance ◽

Glucose Tolerance Test ◽

Polycystic Ovary ◽

Tolerance Test ◽

Oral Glucose ◽

Surrogate Markers ◽

Oral Glucose Tolerance ◽

Ovary Syndrome

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Is there a correlation between blood glucose curve and the insulin resistance during oral glucose tolerance test in females suffering from polycystic ovary syndrome?

Vojnosanitetski pregled ◽

10.2298/vsp190715099s ◽

2019 ◽

pp. 99-99

Author(s):

Svetlana Spremovic-Radjenovic ◽

Miljan Pupovac

Keyword(s):

Insulin Resistance ◽

Blood Glucose ◽

Polycystic Ovary Syndrome ◽

Glucose Tolerance Test ◽

Polycystic Ovary ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Ovary Syndrome ◽

Glucose Curve

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Oral glucose tolerance test vs fasting plasma glucose determination for the assessment of glucose metabolism disturbances in women with Polycystic Ovary Syndrome

Endocrine Abstracts ◽

10.1530/endoabs.56.p937 ◽

2018 ◽

Author(s):

Andres Ortiz ◽

Elena Fernandez ◽

Francisco Alvarez ◽

Elisa Santacruz ◽

Marta Rosillo ◽

...

Keyword(s):

Glucose Metabolism ◽

Polycystic Ovary Syndrome ◽

Glucose Tolerance ◽

Glucose Tolerance Test ◽

Polycystic Ovary ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Ovary Syndrome ◽

Glucose Determination

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Odd variation of 75 g oral glucose tolerance test results in a Japanese patient with polycystic ovary syndrome: a case report

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-006-0275-3 ◽

2006 ◽

Vol 275 (5) ◽

pp. 405-409 ◽

Cited By ~ 2

Author(s):

Kentaro Takahashi ◽

Sandra Mutiara ◽

Nobuyuki Kita ◽

Shunichiro Tsuji ◽

Yoichi Noda ◽

...

Keyword(s):

Case Report ◽

Polycystic Ovary Syndrome ◽

Japanese Patient ◽

Glucose Tolerance Test ◽

Polycystic Ovary ◽

Tolerance Test ◽

Oral Glucose ◽

Test Results ◽

Oral Glucose Tolerance ◽

Ovary Syndrome

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Usefulness of Insulin Sensitivity Indexes derived from Oral Glucose Tolerance Test in Women with Polycystic Ovary Syndrome

The Journal of Korean Diabetes Association ◽

10.4093/jkda.2006.30.4.277 ◽

2006 ◽

Vol 30 (4) ◽

pp. 277 ◽

Cited By ~ 1

Author(s):

Hyo-Jeong Kim ◽

Eun Kyung Byun ◽

Jee-Young Oh ◽

Yeon-Ah Sung ◽

Hye-Won Chung

Keyword(s):

Insulin Sensitivity ◽

Polycystic Ovary Syndrome ◽

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Glucose Tolerance Test ◽

Polycystic Ovary ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Ovary Syndrome

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A new insulin sensitivity index obtained from the oral glucose tolerance test (OGTT) is applicable for evaluating women with polycystic ovary syndrome (PCOS)

Fertility and Sterility ◽

10.1016/s0015-0282(03)00085-2 ◽

2003 ◽

Vol 79 ◽

pp. 7-8

Author(s):

K. Elkind-Hirsch ◽

B. Webster

Keyword(s):

Insulin Sensitivity ◽

Polycystic Ovary Syndrome ◽

Glucose Tolerance Test ◽

Polycystic Ovary ◽

Tolerance Test ◽

Oral Glucose ◽

Sensitivity Index ◽

Oral Glucose Tolerance ◽

Insulin Sensitivity Index ◽

Ovary Syndrome

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STUDY OF GLYCATED HEMOGLOBIN LEVELS IN POLYCYSTIC OVARY SYNDROME

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i5.22729 ◽

2018 ◽

Vol 11 (5) ◽

pp. 191 ◽

Cited By ~ 1

Author(s):

Renuka Pangaluri ◽

Shakthiya T ◽

Vinodhini Vm

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Glycated Hemoglobin ◽

Polycystic Ovary ◽

Resistance Index ◽

Tolerance Test ◽

Oral Glucose ◽

Model Assessment ◽

Ovary Syndrome ◽

Hba1c Levels

Objective: Polycystic ovarian syndrome (PCOS) is often accompanied by insulin resistance, obesity, and cardiometabolic risk factors. Androgen excess-PCOS recommends oral glucose tolerance test or glycated hemoglobin (HbA1C) to evaluate dysglycemia in PCOS subjects. We undertook this study to evaluate the prevalence of elevated HbA1C levels in PCOS women.Methods: The study was carried out among 100 PCOS patients from SRM Hospital, 100 healthy individuals were included as controls. Fasting glucose, HbA1C, Insulin and Homeostasis Model Assessment-Insulin Resistance Index were estimated.Results: Patients with polycystic ovary syndrome showed a significant increase in HbA1C levels (5.799±1.022; 4.96±0.625, p=0.001) when compared to the control group.Conclusion: We found elevated HbA1C levels in PCOS women categorizing 26% as prediabetes and 28% as having type 2 diabetes mellitus.

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