Animal models of disease: preclinical to clinical gene therapy translatability

2021 ◽  
Vol 7 (1) ◽  
pp. 9-19
Author(s):  
Erika Matsumoto Plata ◽  
Carlos R Plata-Salamán
Keyword(s):  
Gene Therapy ◽  
Animal Models ◽  
Animal Models Of Disease ◽  
Clinical Gene Therapy ◽  
Models Of Disease

Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes

2021 ◽  
pp. ASN.2020081177
Author(s):  
Jingping Yang ◽  
Difei Zhang ◽  
Masaru Motojima ◽  
Tsutomu Kume ◽  
Qing Hou ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Transcription Factors ◽  
Animal Models ◽  
Cell Fate ◽  
Control Cell ◽  
Transgenic Animal ◽  
Animal Models Of Disease ◽  
Super Enhancer ◽  
Models Of Disease ◽  
Human Glomerulus

BackgroundTranscriptional programs control cell fate, and identifying their components is critical for understanding diseases caused by cell lesion, such as podocytopathy. Although many transcription factors (TFs) are necessary for cell-state maintenance in glomeruli, their roles in transcriptional regulation are not well understood.MethodsThe distribution of H3K27ac histones in human glomerulus cells was analyzed to identify superenhancer-associated TFs, and ChIP-seq and transcriptomics were performed to elucidate the regulatory roles of the TFs. Transgenic animal models of disease were further investigated to confirm the roles of specific TFs in podocyte maintenance.ResultsSuperenhancer distribution revealed a group of potential TFs in core regulatory circuits in human glomerulus cells, including FOXC1/2, WT1, and LMX1B. Integration of transcriptome and cistrome data of FOXC1/2 in mice resolved transcriptional regulation in podocyte maintenance. FOXC1/2 regulated differentiation-associated transcription in mature podocytes. In both humans and animal models, mature podocyte injury was accompanied by deregulation of FOXC1/2 expression, and FOXC1/2 overexpression could protect podocytes in zebrafish.ConclusionsFOXC1/2 maintain podocyte differentiation through transcriptional stabilization. The genome-wide chromatin resources support further investigation of TFs’ regulatory roles in glomeruli transcription programs.

Review of the biological activity of maslinic acid1

2021 ◽  
Vol 22 ◽  
Author(s):  
Zhang Jing ◽  
Wang Rui ◽  
Li Ruihua ◽  
Yu Hao ◽  
Fang Hengtong
Keyword(s):  
Biological Activity ◽  
Cardiovascular Diseases ◽  
Animal Models ◽  
Mechanism Of Action ◽  
Maslinic Acid ◽  
Animal Models Of Disease ◽  
Positive Effects ◽  
Cancer Inflammation ◽  
Models Of Disease

: Since the discovery of (2α,3β)-2,3-dihydroxyolean-12-en-28-oic acid, also known as maslinic acid, many studies have examined its biological activity, which has been shown to promote health and resist various diseases. This article focuses on previous research on maslinic acid and mainly reviews its reported effects on cardiovascular diseases, neuroprotection, diabetes, cancer, inflammation, and pathogens. Maslinic acid exerts positive effects on both cell and animal models of disease. Although its mechanism of action has not yet been completely elucidated, maslinic acid is feasible as a nutritional additive and has the potential to be developed as a drug.

Current use of animal models of disease for nonclinical safety testing

2020 ◽  
Vol 23-24 ◽  
pp. 11-16
Author(s):  
Diann Blanset ◽  
Julie Hutt ◽  
Sherry Morgan
Keyword(s):  
Animal Models ◽  
Safety Testing ◽  
Animal Models Of Disease ◽  
Models Of Disease

scholarly journals Can Animal Models of Disease Reliably Inform Human Studies?

PLoS Medicine ◽  
2010 ◽  
Vol 7 (3) ◽  
pp. e1000245 ◽  
Author(s):  
H. Bart van der Worp ◽  
David W. Howells ◽  
Emily S. Sena ◽  
Michelle J. Porritt ◽  
Sarah Rewell ◽  
...  
Keyword(s):  
Animal Models ◽  
Human Studies ◽  
Animal Models Of Disease ◽  
Models Of Disease

Pitfalls and Solutions for the Validation of Novel Drugs in Animal Models of Disease

2012 ◽  
Vol 8 (2) ◽  
pp. 181-189 ◽  
Author(s):  
Zoe Johnson ◽  
Christine A. Power ◽  
Amanda E. I. Proudfoot
Keyword(s):  
Animal Models ◽  
Animal Models Of Disease ◽  
Novel Drugs ◽  
Models Of Disease
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