scholarly journals Exercise reduces metabolic burden while altering the immune system in aged mice

Aging ◽  
2021 ◽  
Author(s):  
Kyeong Jin Yoon ◽  
Aram Ahn ◽  
Soo Hong Park ◽  
Seung Hee Kwak ◽  
Seong Eun Kwak ◽  
...  
Keyword(s):  
Immune System ◽  
Aged Mice ◽  
Metabolic Burden

Effect of restraint stress on immune system and experimental B16 melanoma metastasis in aged mice

1997 ◽  
Vol 93 (1-3) ◽  
pp. 107-117 ◽  
Author(s):  
Jun Kanno ◽  
Atsuko Wakikawa ◽  
Masanori Utsuyama ◽  
Katsuiku Hirokawa
Keyword(s):  
Immune System ◽  
Restraint Stress ◽  
B16 Melanoma ◽  
Melanoma Metastasis ◽  
Aged Mice

scholarly journals Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

2016 ◽  
Author(s):  
Melissa N. Conley ◽  
Carmen P. Wong ◽  
Kyle M. Duyck ◽  
Norman Hord ◽  
Emily Ho ◽  
...  
Keyword(s):  
Immune System ◽  
Murine Model ◽  
Gut Microbiome ◽  
Inflammatory Marker ◽  
Low Grade ◽  
Host Immune System ◽  
Cancer Type ◽  
Microbiome Composition ◽  
Aged Mice ◽  
Age Related

Introduction Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the widely observed phenomenon of increased production of inflammatory mediators that accompany this process, referred to as “inflammaging”. While it has been demonstrated that the gut microbiome and immune system interact, the relationship between the gut microbiome and age remains to be clearly defined, particularly in the context of inflammation. The aim of the study was to clarify the associations between age, the gut microbiome, and pro-inflammatory marker serum MCP-1 in a C57BL/6 murine model. Results We used 16S rRNA gene sequencing to profile the composition of fecal microbiota associated with young and aged mice. Our analysis identified an association between microbiome structure and mouse age, and revealed specific groups of taxa whose abundances stratify young and aged mice. This includes the Ruminococcaceae, Clostridiaceae, and Enterobacteriaceae. We also profiled pro-inflammatory serum MCP-1 levels of each mouse and found that aged mice exhibited elevated serum MCP-1, a phenotype consistent with inflammaging. Robust correlation tests identified several taxa whose abundance in the microbiome associates with serum MCP-1 status, indicating that they may interact with the mouse immune system. We find that taxonomically similar organisms can exhibit differing, even opposite, patterns of association with the host immune system. We also find that many of the OTUs that associate with serum MCP-1 also stratify individuals by age. Discussion Our results demonstrate that gut microbiome composition is associated with age and the pro-inflammatory marker, serum MCP-1. The correlation between age, relative abundance of specific taxa in the gut microbiome, and serum MCP-1 status in mice indicates that the gut microbiome may play a modulating role in age-related inflammatory processes. These findings warrant further investigation of taxa associated with the inflammaging phenotype and the role of gut microbiome in the health status and immune function of aged individuals.

scholarly journals Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e1854 ◽  
Author(s):  
Melissa N. Conley ◽  
Carmen P. Wong ◽  
Kyle M. Duyck ◽  
Norman Hord ◽  
Emily Ho ◽  
...  
Keyword(s):  
Immune System ◽  
Murine Model ◽  
Gut Microbiome ◽  
Inflammatory Marker ◽  
Low Grade ◽  
Host Immune System ◽  
Cancer Type ◽  
Microbiome Composition ◽  
Aged Mice ◽  
Age Related

Introduction.Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the widely observed phenomenon of increased production of inflammatory mediators that accompany this process, referred to as “inflammaging.” While it has been demonstrated that the gut microbiome and immune system interact, the relationship between the gut microbiome and age remains to be clearly defined, particularly in the context of inflammation. The aim of our study was to clarify the associations between age, the gut microbiome, and pro-inflammatory marker serum MCP-1 in a C57BL/6 murine model.Results.We used 16S rRNA gene sequencing to profile the composition of fecal microbiota associated with young and aged mice. Our analysis identified an association between microbiome structure and mouse age and revealed specific groups of taxa whose abundances stratify young and aged mice. This includes the Ruminococcaceae, Clostridiaceae, and Enterobacteriaceae. We also profiled pro-inflammatory serum MCP-1 levels of each mouse and found that aged mice exhibited elevated serum MCP-1, a phenotype consistent with inflammaging. Robust correlation tests identified several taxa whose abundance in the microbiome associates with serum MCP-1 status, indicating that they may interact with the mouse immune system. We find that taxonomically similar organisms can exhibit differing, even opposite, patterns of association with the host immune system. We also find that many of the OTUs that associate with serum MCP-1 stratify individuals by age.Discussion.Our results demonstrate that gut microbiome composition is associated with age and the pro-inflammatory marker, serum MCP-1. The correlation between age, relative abundance of specific taxa in the gut microbiome, and serum MCP-1 status in mice indicates that the gut microbiome may play a modulating role in age-related inflammatory processes. These findings warrant further investigation of taxa associated with the inflammaging phenotype and the role of gut microbiome in the health status and immune function of aged individuals.

Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response

2016 ◽  
Vol 7 (2) ◽  
pp. 275-287 ◽  
Author(s):  
A.A. Van Beek ◽  
J.A. Hoogerland ◽  
C. Belzer ◽  
P. De Vos ◽  
W.M. De Vos ◽  
...  
Keyword(s):  
Immune System ◽  
Immune Cells ◽  
Inflammatory Responses ◽  
Interferon Γ ◽  
Bacterial Strains ◽  
Mouse Splenocytes ◽  
Aged Mice ◽  
Inflammatory Conditions ◽  
Cellular Inflammatory Response

Probiotics influence the immune system, both at the local and systemic level. Recent findings suggest the relation between microbiota and the immune system alters with age. Our objective was to address direct effects of six bacterial strains on immune cells from young and aged mice: Lactobacillus plantarum WCFS1, Lactobacillus casei BL23, Lactococcus lactis MG1363, Bifidobacterium breve ATCC15700, Bifidobacterium infantis ATCC15697, and Akkermansia muciniphila ATCC BAA-835. We used splenocytes and naïve or interferon-γ-stimulated bone marrow-derived macrophages (BMDM) as responder populations. All tested bacterial strains induced phenotypic and cytokine responses in splenocytes and BMDM. Based on magnitude of the cellular inflammatory response and cytokine profiles, two subgroups of bacteria were identified, i.e. L. plantarum and L. casei versus B. breve, B. infantis, and A. muciniphila. The latter group of bacteria induced high levels of cytokines produced under inflammatory conditions, including tumour necrosis factor (TNF), interleukin (IL)-6 and IL-10. Responses to L. lactis showed features of both subgroups. In addition, we compared responses by splenocytes and BMDM derived from young mice to those of aged mice, and found that splenocytes and BMDM derived from aged mice had an increased IL-10 production and dysregulated IL-6 and TNF production compared to young immune cells. Overall, our study shows differential inflammatory responses to distinct bacterial strains, and profound age-dependent effects. These findings, moreover, support the view that immune environment importantly influences bacterial immune effects.

scholarly journals Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

2008 ◽  
Vol 22 (3) ◽  
pp. 301-311 ◽  
Author(s):  
Jing Chen ◽  
Jessica B. Buchanan ◽  
Nathan L. Sparkman ◽  
Jonathan P. Godbout ◽  
Gregory G. Freund ◽  
...  
Keyword(s):  
Working Memory ◽  
Immune System ◽  
Innate Immune System ◽  
Innate Immune ◽  
Aged Mice ◽  
Stimulation Of

scholarly journals Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

2016 ◽  
Author(s):  
Melissa N. Conley ◽  
Carmen P. Wong ◽  
Kyle M. Duyck ◽  
Norman Hord ◽  
Emily Ho ◽  
...  
Keyword(s):  
Immune System ◽  
Murine Model ◽  
Gut Microbiome ◽  
Inflammatory Marker ◽  
Low Grade ◽  
Host Immune System ◽  
Cancer Type ◽  
Microbiome Composition ◽  
Aged Mice ◽  
Age Related

Introduction Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the widely observed phenomenon of increased production of inflammatory mediators that accompany this process, referred to as “inflammaging”. While it has been demonstrated that the gut microbiome and immune system interact, the relationship between the gut microbiome and age remains to be clearly defined, particularly in the context of inflammation. The aim of the study was to clarify the associations between age, the gut microbiome, and pro-inflammatory marker serum MCP-1 in a C57BL/6 murine model. Results We used 16S rRNA gene sequencing to profile the composition of fecal microbiota associated with young and aged mice. Our analysis identified an association between microbiome structure and mouse age, and revealed specific groups of taxa whose abundances stratify young and aged mice. This includes the Ruminococcaceae, Clostridiaceae, and Enterobacteriaceae. We also profiled pro-inflammatory serum MCP-1 levels of each mouse and found that aged mice exhibited elevated serum MCP-1, a phenotype consistent with inflammaging. Robust correlation tests identified several taxa whose abundance in the microbiome associates with serum MCP-1 status, indicating that they may interact with the mouse immune system. We find that taxonomically similar organisms can exhibit differing, even opposite, patterns of association with the host immune system. We also find that many of the OTUs that associate with serum MCP-1 also stratify individuals by age. Discussion Our results demonstrate that gut microbiome composition is associated with age and the pro-inflammatory marker, serum MCP-1. The correlation between age, relative abundance of specific taxa in the gut microbiome, and serum MCP-1 status in mice indicates that the gut microbiome may play a modulating role in age-related inflammatory processes. These findings warrant further investigation of taxa associated with the inflammaging phenotype and the role of gut microbiome in the health status and immune function of aged individuals.

scholarly journals Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice

Nature Aging ◽  
2021 ◽  
Author(s):  
Sinduya Krishnarajah ◽  
Florian Ingelfinger ◽  
Ekaterina Friebel ◽  
Dilay Cansever ◽  
Ana Amorim ◽  
...  
Keyword(s):  
Immune System ◽  
Single Cell ◽  
Aged Mice ◽  
Single Cell Profiling ◽  
Solid Tissues

Modulating effects of a decoction of a traditional Japanese herbal formula, hochuekkito (with Hedysari radix and Atractylodis rhizoma), on the local mucosal immune system of aged mice

2019 ◽  
Vol 6 (3) ◽  
pp. 156-164 ◽  
Author(s):  
Mieko Kajita ◽  
Kayako Saso ◽  
Yosuke Tanaka ◽  
Takayuki Nagai ◽  
Hiroaki Kiyohara
Keyword(s):  
Immune System ◽  
Mucosal Immune System ◽  
Herbal Formula ◽  
Aged Mice

Increased Oxygen Tensions Influence Subset Composition of the Cellular Immune System in Aged Mice

1994 ◽  
Vol 9 (1) ◽  
pp. 39-54 ◽  
Author(s):  
Allen K. Lee ◽  
Raymond B. Hester ◽  
Joseph H. Coggin ◽  
Sheldon F. Gottlieb
Keyword(s):  
Immune System ◽  
Aged Mice ◽  
Cellular Immune System ◽  
Oxygen Tensions ◽  
Cellular Immune

Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

2005 ◽  
Vol 19 (10) ◽  
pp. 1329-1331 ◽  
Author(s):  
J. P. Godbout ◽  
J. Chen ◽  
J. Abraham ◽  
A. F. Richwine ◽  
B. M. Berg ◽  
...  
Keyword(s):  
Immune System ◽  
Innate Immune System ◽  
Sickness Behavior ◽  
Innate Immune ◽  
Aged Mice
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