scholarly journals Solid predominant histologic subtype and early recurrence predict poor postrecurrence survival in patients with stage I lung adenocarcinoma

Oncotarget ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 7050-7058 ◽  
Author(s):  
Jizhuang Luo ◽  
Rui Wang ◽  
Baohui Han ◽  
Jie Zhang ◽  
Heng Zhao ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Early Recurrence ◽  
Stage I ◽  
Histologic Subtype

scholarly journals Solid Predominant Histologic Subtype in Resected Stage I Lung Adenocarcinoma Is an Independent Predictor of Early, Extrathoracic, Multisite Recurrence and of Poor Postrecurrence Survival

2015 ◽  
Vol 33 (26) ◽  
pp. 2877-2884 ◽  
Author(s):  
Hideki Ujiie ◽  
Kyuichi Kadota ◽  
Jamie E. Chaft ◽  
Daniel Buitrago ◽  
Camelia S. Sima ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Primary Tumor ◽  
Independent Predictor ◽  
International Association ◽  
Multivariable Analysis ◽  
Early Recurrence ◽  
Stage I ◽  
European Respiratory Society ◽  
Histologic Subtype

Purpose To examine the significance of the proposed International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society (IASLC/ATS/ERS) histologic subtypes of lung adenocarcinoma for patterns of recurrence and, among patients who recur following resection of stage I lung adenocarcinoma, for postrecurrence survival (PRS). Patients and Methods We reviewed patients with stage I lung adenocarcinoma who had undergone complete surgical resection from 1999 to 2009 (N = 1,120). Tumors were subtyped by using the IASLC/ATS/ERS classification. The effects of the dominant subtype on recurrence and, among patients who recurred, on PRS were investigated. Results Of 1,120 patients identified, 188 had recurrent disease, 103 of whom died as a result of lung cancer. Among patients who recurred, 2-year PRS was 45%, and median PRS was 26.1 months. Compared with patients with nonsolid tumors, patients with solid predominant tumors had earlier (P = .007), more extrathoracic (P < .001), and more multisite (P = .011) recurrences. Multivariable analysis of primary tumor factors revealed that, among patients who recurred, solid predominant histologic pattern in the primary tumor (hazard ratio [HR], 1.76; P = .016), age older than 65 years (HR, 1.63; P = .01), and sublobar resection (HR, 1.6; P = .01) were significantly associated with worse PRS. Presence of extrathoracic metastasis (HR, 1.76; P = .013) and age older than 65 years at the time of recurrence (HR, 1.7; P = .014) were also significantly associated with worse PRS. Conclusion In patients with stage I primary lung adenocarcinoma, solid predominant subtype is an independent predictor of early recurrence and, among those patients who recur, of worse PRS. Our findings provide a rationale for investigating adjuvant therapy and identify novel therapeutic targets for patients with solid predominant lung adenocarcinoma.

MUC1 mucin mRNA expression in stage I lung adenocarcinoma and its association with early recurrence

1999 ◽  
Vol 67 (3) ◽  
pp. 810-814 ◽  
Author(s):  
Akira Ohgami ◽  
Tohru Tsuda ◽  
Toshihiro Osaki ◽  
Tetsuya Mitsudomi ◽  
Yasuo Morimoto ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Mrna Expression ◽  
Early Recurrence ◽  
Stage I ◽  
Muc1 Mucin

scholarly journals Impact of Solid Minor Histologic Subtype in Postsurgical Prognosis of Stage I Lung Adenocarcinoma

2018 ◽  
Vol 105 (1) ◽  
pp. 302-308 ◽  
Author(s):  
Tianxiang Chen ◽  
Jizhuang Luo ◽  
Haiyong Gu ◽  
Yu Gu ◽  
Qingyuan Huang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Stage I ◽  
Histologic Subtype

scholarly journals Prognostic impact of tumour spread through air space in radiological subsolid and pure solid lung adenocarcinoma

2020 ◽  
Author(s):  
Yifan Zhong ◽  
Yong Xu ◽  
Jiajun Deng ◽  
Tingting Wang ◽  
Xiwen Sun ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Ground Glass Opacity ◽  
Stage I ◽  
Prognostic Impact ◽  
Histologic Subtype ◽  
Tumour Spread ◽  
Air Space ◽  
Solid Lesions

Abstract OBJECTIVES The aim of the study was to investigate the relationship between ground-glass opacity (GGO) and tumour spread through air space (STAS), as well as their joint influence on the prognosis of stage I lung adenocarcinoma. METHODS A total of 620 consecutive patients with surgically resected lung adenocarcinoma between January 2011 and December 2012 were reviewed retrospectively. The relevance of STAS and GGO was analysed by logistic regression, and their prognostic significance was investigated via the Kaplan–Meier method and Cox regression models. Furthermore, to determine the magnitude of the prognostic impact of GGO and STAS, we respectively performed survival analysis in subgroups according to the presence of STAS and GGO. RESULTS Of all 620 cases, 26.7% were positive for STAS, and 32.9% had a GGO component. STAS was present in 10.8% of part-solid lesions and 34.9% of pure solid nodules (P &lt; 0.001). Lepidic-predominant histologic subtype, GGO component and pathological T stage exhibited significant relevance to the presence of STAS. For the whole population, STAS and GGO component were each revealed as independent predictors for overall survival and recurrence-free survival (each with P &lt; 0.001). Interestingly, in the GGO-present subgroup, STAS failed to significantly stratify prognosis. However, in the STAS-positive subgroup, the presence of a GGO component was independently associated with favourable oncological results. CONCLUSIONS STAS is associated with a GGO component, and each factor was a significant predictor for the prognosis of stage I lung adenocarcinoma. Moreover, the favourable prognostic impact of a GGO component was greater than the adverse prognostic influence of STAS, indicating that GGO is a more reliable prognostic predictor in stage I lung adenocarcinoma.

scholarly journals Impact of the micropapillary component on the timing of recurrence in patients with resected lung adenocarcinoma

2020 ◽  
Vol 58 (5) ◽  
pp. 1010-1018 ◽  
Author(s):  
Katsuya Watanabe ◽  
Kentaro Sakamaki ◽  
Hiroyuki Ito ◽  
Tomoyuki Yokose ◽  
Kozo Yamada ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Poor Prognosis ◽  
Cox Regression ◽  
Postoperative Recurrence ◽  
Early Recurrence ◽  
Stage I ◽  
Hazard Curves ◽  
And Gender ◽  
The Impact

Abstract OBJECTIVES A micropapillary (MIP) component is reported to be associated with a poor prognosis in patients with completely resected lung adenocarcinoma. The purpose of this study was to investigate the impact of an MIP component on the timing of postoperative recurrence using hazard curves. METHODS A total of 1289 patients with lung adenocarcinoma who underwent complete pulmonary resection from 2008 to 2015 were studied. Hazard curves representing the changes in hazard over time were evaluated. RESULTS The hazard curve displayed an initial wide, high peak within 1 year after surgery in patients with an MIP component, whereas some gentle peaks around the second year were noted in patients without an MIP component. The presence of an MIP component was associated with a worse recurrence-free survival and an early recurrence in stage I patients but not in advanced-stage patients. In multivariable Cox regression, the presence of an MIP component and lymph node metastasis, pleural invasion and gender were associated with a poor prognosis. CONCLUSIONS Patients with an MIP component retained a high risk of early recurrence after surgery, and the risk for recurrence persisted over the long term. Even after complete resection in stage I lung adenocarcinoma patients, an MIP component remains correlated with a poor prognosis.

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