scholarly journals KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

Oncotarget ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 3206-3225 ◽  
Author(s):  
Qing Wen ◽  
Philip D. Dunne ◽  
Paul G. O’Reilly ◽  
Gerald Li ◽  
Anthony J. Bjourson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Angiotensin Ii ◽  
Angiotensin Ii Receptor Blockers ◽  
Cancer Gene ◽  
Angiotensin Ii Receptor ◽  
Gene Signatures ◽  
Receptor Blockers

The Impact of Angiotensin-II Receptor Blockers on Cardiovascular Events in Hypertensive Patients – Evidence from Real-life Databases

2010 ◽  
Vol 6 (3) ◽  
pp. 33
Author(s):  
Robert J Petrella ◽  
Keyword(s):  
Angiotensin Ii ◽  
Antihypertensive Drugs ◽  
Real Life ◽  
Angiotensin Ii Receptor Blockers ◽  
Angiotensin Ii Receptor ◽  
Real World Setting ◽  
Actual Experience ◽  
Receptor Blockers ◽  
Randomised Controlled ◽  
The Impact

It is widely recognised that hypertension is a major risk factor for the development of future cardiovascular (CV) events, which in turn are a major cause of morbidity and mortality. Blood pressure (BP) control with antihypertensive drugs has been shown to reduce the risk of CV events. Angiotensin-II receptor blockers (ARBs) are one such class of antihypertensive drugs and randomised controlled trials (RCTs) have shown ARB-based therapies to have effective BP-lowering properties. However, data obtained under these tightly controlled settings do not necessarily reflect actual experience in clinical practice. Real-life databases may offer alternative information that reflects an uncontrolled real-world setting and complements and expands on the findings of clinical trials. Recent analyses of practice-based real-life databases have shown ARB-based therapies to be associated with better persistence and adherence rates and with superior BP control than non-ARB-based therapies. Analyses of real-life databases also suggest that ARB-based therapies may be associated with a lower risk of CV events than other antihypertensive-drug-based therapies.

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