scholarly journals G-T haplotype established by rs3785889-rs16941382 in GOSR2 gene is associated with coronary artery disease in Chinese Han population

Oncotarget ◽  
2017 ◽  
Vol 8 (47) ◽  
pp. 82165-82173 ◽  
Author(s):  
Shuo Pan ◽  
Gong-Chang Guan ◽  
Ying Lv ◽  
Zhong-Wei Liu ◽  
Fu-Qiang Liu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease ◽  
T Haplotype

scholarly journals GW26-e2187 Association between Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Han Population

2015 ◽  
Vol 66 (16) ◽  
pp. C133
Author(s):  
Hongmei Lai ◽  
Qingjie Chen ◽  
Yining Yang ◽  
Xiaomei Li ◽  
Rui Xu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Genetic Variation ◽  
Coronary Artery ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease

Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population

Cytokine ◽  
2022 ◽  
Vol 150 ◽  
pp. 155761
Author(s):  
Lingfeng Zha ◽  
Jiangtao Dong ◽  
Qianwen Chen ◽  
Yuhua Liao ◽  
Hongsong Zhang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Association ◽  
Association Analysis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Genetic Association Analysis ◽  
Han Population ◽  
Artery Disease

scholarly journals NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 33662-33674 ◽  
Author(s):  
Qin Hu ◽  
Qiji Liu ◽  
Shasha Wang ◽  
Xi Zhen ◽  
Zhimian Zhang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Multicenter Study ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease ◽  
Increased Susceptibility

Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population

2010 ◽  
Vol 25 (5) ◽  
pp. 368-373 ◽  
Author(s):  
Kai Zhang ◽  
Yuan-yuan Wang ◽  
Qi-ji Liu ◽  
Hui Wang ◽  
Fang-fang Liu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Single Nucleotide Polymorphisms ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Single Nucleotide ◽  
Han Population ◽  
Artery Disease

scholarly journals Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Li-li Liang ◽  
Lin Chen ◽  
Meng-yuan Zhou ◽  
Meng-yun Cai ◽  
Jie Cheng ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Endothelin 1 ◽  
Increased Risk ◽  
Artery Disease ◽  
Cad Risk

Endothelin-1 (ET-1) plays important roles in endothelial dysfunction, vascular physiology, inflammation, and atherosclerosis. Nonetheless, the role of ET-1 (EDN1) gene variants on coronary artery disease (CAD) risk remains poorly understood. The aim of the present study was to evaluate the role of EDN1 gene polymorphisms on individual susceptibility to CAD. We genotyped five tagSNPs (single-nucleotide polymorphisms) (rs6458155, rs4145451, rs9369217, rs3087459, and rs2070699) within EDN1 gene in 525 CAD patients and 675 control subjects. In a multivariate logistic regression analysis, we detected an association of rs6458155 in EDN1 gene with the CAD risk; compared with the TT homozygotes, the CT heterozygotes (odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.02–2.29, P=0.040) and the CC homozygotes (OR = 1.55, 95% CI = 1.01–2.36, P=0.043) were statistically significantly associated with the increased risk for CAD. A similar trend of the association was found in dominant model (OR = 1.53, 95% CI = 1.05–2.25, P=0.029). Consistently, the haplotype rs6458155C-rs4145451C containing rs6458155 C allele exhibited the increased CAD risk (OR = 1.22, 95% CI = 1.03–1.43, and P=0.018). In addition, CT genotype of rs6458155 conferred the increased plasma ET-1 levels compared with TT genotype (P<0.05). No association of the other four tagSNPs in EDN1 gene with CAD risk was observed. In conclusion, our study provides the first evidence that EDN1 tagSNP rs6458155 is associated with CAD risk in the Chinese Han population, which is probably due to the influence of the circulating ET-1 levels.

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