Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model

Yuuki Ohara; Shan Hwu Chew; Nobuaki Misawa; Shenqi Wang; Daiki Somiya; Kae Nakamura; Hiroaki Kajiyama; Fumitaka Kikkawa; Yuta Tsuyuki; Li Jiang; Kyoko Yamashita; Yoshitaka Sekido; Kenneth E. Lipson; Shinya Toyokuni

doi:10.18632/oncotarget.24892

Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model

Oncotarget ◽

10.18632/oncotarget.24892 ◽

2018 ◽

Vol 9 (26) ◽

pp. 18494-18509 ◽

Cited By ~ 15

Author(s):

Yuuki Ohara ◽

Shan Hwu Chew ◽

Nobuaki Misawa ◽

Shenqi Wang ◽

Daiki Somiya ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Connective Tissue ◽

Mouse Model ◽

Connective Tissue Growth Factor ◽

Malignant Mesothelioma ◽

Tissue Growth ◽

Specific Monoclonal Antibody ◽

Orthotopic Mouse Model

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Connective tissue growth factor–specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-05-0516 ◽

2006 ◽

Vol 5 (5) ◽

pp. 1108-1116 ◽

Cited By ~ 114

Author(s):

Takuma Aikawa ◽

Jason Gunn ◽

Suzanne M. Spong ◽

Stephen J. Klaus ◽

Murray Korc

Keyword(s):

Pancreatic Cancer ◽

Growth Factor ◽

Connective Tissue ◽

Mouse Model ◽

Tumor Growth ◽

Connective Tissue Growth Factor ◽

Specific Antibody ◽

Tissue Growth ◽

Orthotopic Mouse Model

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Overexpression of connective tissue growth factor promotes pancreatic adenocarcinoma xenograft formation and decreases survival in a nude mouse model

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2005.06.194 ◽

2005 ◽

Vol 201 (3) ◽

pp. S83

Author(s):

Ali Salim ◽

Nadja Dornhofer ◽

Randall Nacamuli ◽

Michael T. Longaker ◽

Amato Giaccia

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Mouse Model ◽

Pancreatic Adenocarcinoma ◽

Nude Mouse ◽

Connective Tissue Growth Factor ◽

Tissue Growth ◽

Nude Mouse Model

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FG-3019, a human monoclonal antibody to connective tissue growth factor (CTGF), with gemcitabine/erlotinib (G/E) in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC).

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.4138 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 4138-4138 ◽

Cited By ~ 2

Author(s):

Vincent J. Picozzi ◽

J. Marc Pipas ◽

Albert Koong ◽

Amato Giaccia ◽

Nathan Bahary ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Connective Tissue ◽

Pancreatic Ductal Adenocarcinoma ◽

Connective Tissue Growth Factor ◽

Human Monoclonal Antibody ◽

Locally Advanced ◽

Tissue Growth ◽

Ductal Adenocarcinoma

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Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth

Annals of Hematology ◽

10.1007/s00277-013-1939-2 ◽

2013 ◽

Vol 93 (3) ◽

pp. 485-492 ◽

Cited By ~ 28

Author(s):

Hongbo Lu ◽

Kensuke Kojima ◽

Venkata Lokesh Battula ◽

Borys Korchin ◽

Yuexi Shi ◽

...

Keyword(s):

Monoclonal Antibody ◽

Acute Lymphoblastic Leukemia ◽

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Lymphoblastic Leukemia ◽

Tissue Growth ◽

Preclinical Models

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Connective Tissue Growth Factor–Specific Monoclonal Antibody Therapy Inhibits Pancreatic Tumor Growth and Metastasis

Cancer Research ◽

10.1158/0008-5472.can-06-0081 ◽

2006 ◽

Vol 66 (11) ◽

pp. 5816-5827 ◽

Cited By ~ 111

Author(s):

Nadja Dornhöfer ◽

Suzanne Spong ◽

Kevin Bennewith ◽

Ali Salim ◽

Stephen Klaus ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Connective Tissue ◽

Tumor Growth ◽

Pancreatic Tumor ◽

Antibody Therapy ◽

Tissue Growth ◽

Monoclonal Antibody Therapy ◽

Specific Monoclonal Antibody ◽

Tumor Growth And Metastasis

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Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor‐β‐induced mouse fibrosis

Journal of Cellular Physiology ◽

10.1002/jcp.21449 ◽

2008 ◽

Vol 216 (3) ◽

pp. 680-687 ◽

Cited By ~ 55

Author(s):

Yuka Ikawa ◽

Poh‐Sing Ng ◽

Koki Endo ◽

Miki Kondo ◽

Sonoko Chujo ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth ◽

Neutralizing Monoclonal Antibody

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Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy

Journal of Molecular and Cellular Cardiology ◽

10.1016/j.yjmcc.2015.11.003 ◽

2015 ◽

Vol 89 ◽

pp. 214-222 ◽

Cited By ~ 17

Author(s):

Yevgeniya E. Koshman ◽

Mark D. Sternlicht ◽

Taehoon Kim ◽

Christopher P. O'Hara ◽

Christopher A. Koczor ◽

...

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Mouse Model ◽

Cardiac Function ◽

Dilated Cardiomyopathy ◽

Connective Tissue Growth Factor ◽

Tissue Remodeling ◽

Tissue Growth

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Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade

Cell Cycle ◽

10.4161/cc.21397 ◽

2012 ◽

Vol 11 (18) ◽

pp. 3373-3379 ◽

Cited By ~ 27

Author(s):

Makiko Fujii ◽

Hayao Nakanishi ◽

Takeshi Toyoda ◽

Ichidai Tanaka ◽

Yutaka Kondo ◽

...

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Malignant Mesothelioma ◽

Tissue Growth ◽

Signaling Cascade ◽

Hippo Signaling ◽

Tgfβ Signaling

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Inhibition of pancreatic tumor growth and progression by a human monoclonal antibody specific for connective tissue growth factor

Journal of Clinical Oncology ◽

10.1200/jco.2005.23.16_suppl.4150 ◽

2005 ◽

Vol 23 (16_suppl) ◽

pp. 4150-4150

Author(s):

S. M. Spong ◽

N. Dornhofer ◽

C. Wong ◽

E. Lomongsod ◽

A. Salim ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Connective Tissue ◽

Tumor Growth ◽

Connective Tissue Growth Factor ◽

Pancreatic Tumor ◽

Human Monoclonal Antibody ◽

Tissue Growth

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Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy

International Journal of Experimental Pathology ◽

10.1111/j.1365-2613.2010.00750.x ◽

2010 ◽

Vol 92 (1) ◽

pp. 57-65 ◽

Cited By ~ 44

Author(s):

Carol G. Au ◽

Tanya L. Butler ◽

Megan C. Sherwood ◽

Jonathan R. Egan ◽

Kathryn N. North ◽

...

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Mouse Model ◽

Connective Tissue Growth Factor ◽

Cardiac Fibrosis ◽

Tissue Growth ◽

Mdx Mouse ◽

Dystrophic Cardiomyopathy

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