scholarly journals PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription

Oncotarget ◽  
2015 ◽  
Vol 6 (25) ◽  
pp. 21406-21420 ◽  
Author(s):  
Hai-Long Li ◽  
Li Han ◽  
Hai-Rong Chen ◽  
Fei Meng ◽  
Qing-Hua Liu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Invasion And Metastasis ◽  
Cell Renal Cell Carcinoma

scholarly journals XRCC1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis through suppressing MMP-2 and MMP-9

Oncotarget ◽  
2017 ◽  
Vol 8 (65) ◽  
pp. 109382-109392 ◽  
Author(s):  
Qing-Hua Liu ◽  
You Wang ◽  
Hong-Mei Yong ◽  
Ping-Fu Hou ◽  
Jie Pan ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Invasion And Metastasis ◽  
Cell Renal Cell Carcinoma

638: Macroscopic Tumor Necrosis is a Prognostic Indicator for Non-Metastatic Clear Cell Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 214-214
Author(s):  
Sung Kyu Hong ◽  
Byung Kyu Han ◽  
In Ho Chang ◽  
June Hyun Han ◽  
Ji Hyung Yu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Necrosis ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Cell Renal Cell Carcinoma ◽  
Macroscopic Tumor

Expression of Aquaporin 1 in Primary Renal Tumors: A Prognostic Indicator for Clear-Cell Renal Cell Carcinoma

2009 ◽  
Vol 56 (4) ◽  
pp. 690-699 ◽  
Author(s):  
Ying Huang ◽  
Takayuki Murakami ◽  
Futoshi Sano ◽  
Keiichi Kondo ◽  
Noboru Nakaigawa ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Renal Tumors ◽  
Cell Renal Cell Carcinoma ◽  
Aquaporin 1

C120 DETECTION OF P53 PROTEIN AS A PROGNOSTIC INDICATOR IN CLEAR CELL RENAL CELL CARCINOMA

2010 ◽  
Vol 9 (6) ◽  
pp. 648-649
Author(s):  
G. Dordevic ◽  
E. Babarovic ◽  
K. Krpina ◽  
K. Matusan llijas ◽  
N. Jonjic
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
P53 Protein ◽  
Prognostic Indicator ◽  
Cell Renal Cell Carcinoma

scholarly journals RNF43 is a Novel Tumor Suppressor and Prognostic Indicator in Clear Cell Renal Cell Carcinoma

2021 ◽  
Author(s):  
Dawei Zhu ◽  
Lei Zhang ◽  
Xiaokai Shi ◽  
Shenglin Gao ◽  
Chuang Yue ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Cell Renal Cell Carcinoma ◽  
Targeted Drug

Identifying prognostic indicators of clear cell renal cell carcinoma (ccRCC) and elucidating the mechanisms underlying ccRCC progression are crucial for improving ccRCC patient prognosis. This study investigated the clinical significance and biological role of Ring finger protein 43 ( RNF43) in ccRCC. Two independent cohorts of patients with ccRCC were employed to determine the prognostic significance of RNF43 by immunohistochemistry and statistical analyses. In vitro and in vivo experiments, RNA-seq, and other techniques were used to determine the biological role of RNF43 in ccRCC and related molecular mechanisms. RNF43 expression was commonly decreased in ccRCC specimens, and low expression of RNF43 indicated a higher TNM stage, SSIGN score, and WHO/ISUP grade and short survival in patients with ccRCC. Additionally, RNF43 overexpression suppressed the proliferation, migration, and targeted drug resistance of ccRCC cells, while the knockdown of RNF43 enhanced these characteristics of ccRCC. RNF43 knockdown activated YAP signaling by decreasing YAP phosphorylation by p-LATS1/2 and increasing the transcription and nuclear distribution of YAP. By contrast, RNF43 overexpression showed the opposite effects. Decreasing YAP abolished the effect of RNF43 knockdown in promoting the malignant features of ccRCC. Additionally, restoring RNF43 expression suppressed the resistance of the targeted drug pazopanib in in vivo orthotopic ccRCC. Furthermore, combining the expression of RNF43 andYAP with TNM stage or the SSIGN score exhibited greater accuracy than any of these indicators alone in assessing the postoperative prognosis of ccRCC patients. In summary, our study identified a novel tumor suppressor, RNF43, which is also a prognostic indicator and potential target for ccRCC potential target for ccRCC.

scholarly journals miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Cheng He ◽  
Zhi-Yong Chen ◽  
Yang Li ◽  
Zhong-Qing Yang ◽  
Feng Zeng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Cell Invasion ◽  
Renal Cell ◽  
Clear Cell ◽  
Invasion And Metastasis ◽  
Cell Renal Cell Carcinoma

scholarly journals High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma

2008 ◽  
Vol 122 (10) ◽  
pp. 2391-2397 ◽  
Author(s):  
Hideyuki Abe ◽  
Takao Kamai ◽  
Hiromichi Shirataki ◽  
Tetsunari Oyama ◽  
Kyoko Arai ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
High Expression ◽  
Invasion And Metastasis ◽  
Cell Renal Cell Carcinoma ◽  
Ran Gtpase ◽  
Local Invasion

TPX2 as a prognostic indicator and potential therapeutic target in clear cell renal cell carcinoma

2017 ◽  
Vol 35 (5) ◽  
pp. 286-293 ◽  
Author(s):  
Zachary A. Glaser ◽  
Harold D. Love ◽  
Shunhua Guo ◽  
Lan Gellert ◽  
Sam S. Chang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Therapeutic Target ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Potential Therapeutic Target ◽  
Cell Renal Cell Carcinoma
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