scholarly journals Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model

Oncotarget ◽  
2015 ◽  
Vol 6 (39) ◽  
pp. 42091-42104 ◽  
Author(s):  
Elisabetta Benedetti ◽  
Andrea Antonosante ◽  
Michele d’Angelo ◽  
Loredana Cristiano ◽  
Renato Galzio ◽  
...  
Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3185
Author(s):  
Dina Farrakhova ◽  
Igor Romanishkin ◽  
Yuliya Maklygina ◽  
Lina Bezdetnaya ◽  
Victor Loschenov

Spectroscopic approach with fluorescence time resolution allows one to determine the state of a brain tumor and its microenvironment via changes in the fluorescent dye’s fluorescence lifetime. Indocyanine green (ICG) is an acknowledged infra-red fluorescent dye that self-assembles into stable aggregate forms (ICG NPs). ICG NPs aggregates have a tendency to accumulate in the tumor with a maximum accumulation at 24 h after systemic administration, enabling extended intraoperative diagnostic. Fluorescence lifetime analysis of ICG and ICG NPs demonstrates different values for ICG monomers and H-aggregates, indicating promising suitability for fluorescent diagnostics of brain tumors due to their affinity to tumor cells and stability in biological tissue.


1996 ◽  
Vol 55 (5) ◽  
pp. 628
Author(s):  
M. T. Curtis ◽  
R. L. Knobler ◽  
J. Gordon ◽  
C. Gonzalez ◽  
S. Vinitski ◽  
...  

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 90061-90064 ◽  
Author(s):  
Chia-Hao Su ◽  
Fong-Yu Cheng

A novel nanocomposite composed of highly safe and US-FDA-approved Fe3O4 NPs and alginate shows significant anti-brain tumor activity.


1989 ◽  
Vol 24 (12) ◽  
pp. S96
Author(s):  
S L Mitchell ◽  
B D Ross ◽  
H Merkle ◽  
M Garwood

2020 ◽  
Vol 17 (4) ◽  
pp. 986-1001
Author(s):  
Wu Zeng ◽  
Betty Yuen Kwan Law ◽  
Vincent Kam Wai Wong ◽  
Denise So Bik Chan ◽  
Simon Wing Fai Mok ◽  
...  

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