scholarly journals Analysis of Fluorescence Decay Kinetics of Indocyanine Green Monomers and Aggregates in Brain Tumor Model In Vivo

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3185
Author(s):  
Dina Farrakhova ◽  
Igor Romanishkin ◽  
Yuliya Maklygina ◽  
Lina Bezdetnaya ◽  
Victor Loschenov
Keyword(s):  
Brain Tumor ◽  
Indocyanine Green ◽  
Fluorescence Lifetime ◽  
Tumor Model ◽  
Fluorescence Decay ◽  
Decay Kinetics ◽  
Lifetime Analysis ◽  
Fluorescence Decay Kinetics ◽  
Brain Tumor Model

Spectroscopic approach with fluorescence time resolution allows one to determine the state of a brain tumor and its microenvironment via changes in the fluorescent dye’s fluorescence lifetime. Indocyanine green (ICG) is an acknowledged infra-red fluorescent dye that self-assembles into stable aggregate forms (ICG NPs). ICG NPs aggregates have a tendency to accumulate in the tumor with a maximum accumulation at 24 h after systemic administration, enabling extended intraoperative diagnostic. Fluorescence lifetime analysis of ICG and ICG NPs demonstrates different values for ICG monomers and H-aggregates, indicating promising suitability for fluorescent diagnostics of brain tumors due to their affinity to tumor cells and stability in biological tissue.

scholarly journals Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model

Oncotarget ◽  
2015 ◽  
Vol 6 (39) ◽  
pp. 42091-42104 ◽  
Author(s):  
Elisabetta Benedetti ◽  
Andrea Antonosante ◽  
Michele d’Angelo ◽  
Loredana Cristiano ◽  
Renato Galzio ◽  
...  
Keyword(s):  
Cell Death ◽  
Brain Tumor ◽  
Tumor Growth ◽  
Tumor Model ◽  
Autophagic Cell Death ◽  
Primary Cells ◽  
Human Glioblastoma ◽  
Brain Tumor Model

The fluorescence decay kinetics of in vivo chlorophyll measured using low intensity excitation

1979 ◽  
Vol 545 (1) ◽  
pp. 165-174 ◽  
Author(s):  
G.S. Beddard ◽  
G.R. Fleming ◽  
G. Porter ◽  
G.F.W. Searle ◽  
J.A. Synowiec
Keyword(s):  
Fluorescence Decay ◽  
Decay Kinetics ◽  
Low Intensity ◽  
Fluorescence Decay Kinetics ◽  
Kinetics Of

In vitro and in vivo applications of alginate/iron oxide nanocomposites for theranostic molecular imaging in a brain tumor model

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 90061-90064 ◽  
Author(s):  
Chia-Hao Su ◽  
Fong-Yu Cheng
Keyword(s):  
Brain Tumor ◽  
Iron Oxide ◽  
Molecular Imaging ◽  
Tumor Model ◽  
Brain Tumor Model ◽  
Us Fda

A novel nanocomposite composed of highly safe and US-FDA-approved Fe3O4 NPs and alginate shows significant anti-brain tumor activity.

Effects of Hyperglycemia on pH and Blood Flow In a Brain Tumor Model: An In Vivo Study

1989 ◽  
Vol 24 (12) ◽  
pp. S96
Author(s):  
S L Mitchell ◽  
B D Ross ◽  
H Merkle ◽  
M Garwood
Keyword(s):  
Blood Flow ◽  
Brain Tumor ◽  
Tumor Model ◽  
In Vivo Study ◽  
Brain Tumor Model

scholarly journals In Vivo Synthesized Proteins with Monoexponential Fluorescence Decay Kinetics

2004 ◽  
Vol 126 (1) ◽  
pp. 22-23 ◽  
Author(s):  
Jaap Broos ◽  
Francesco Maddalena ◽  
Ben H. Hesp
Keyword(s):  
Fluorescence Decay ◽  
Decay Kinetics ◽  
Fluorescence Decay Kinetics

A New Fiber-Optic-Based Multifrequency Phase-Modulation Fluorometer

1988 ◽  
Vol 42 (8) ◽  
pp. 1531-1537 ◽  
Author(s):  
Frank V. Bright
Keyword(s):  
Fluorescence Lifetime ◽  
Phase Modulation ◽  
Fiber Optic ◽  
Fluorescence Decay ◽  
Fiber Optic Probe ◽  
Decay Kinetics ◽  
Spectral Coverage ◽  
New Instrument ◽  
Fluorescence Decay Kinetics ◽  
Optic Probe

A new fiber-optic-based fluorescence lifetime instrument is described which is useful for the study of complex fluorescence decay kinetics. The new instrument consists of a multifrequency phase fluorometer coupled to a fiber-optic probe. To demonstrate the power of the new instrument, we show results for the unequivocal resolution of single, double, and triple exponential decays of fluorescence. In addition, spectral coverage in the ultraviolet and visible regions is possible, and lifetimes from approximately 200 ns to 150 ps are easily determined for samples as dilute as 0.1 μM.

scholarly journals HM30181A, a potent P-glycoprotein inhibitor, potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model

2020 ◽  
Vol 17 (4) ◽  
pp. 986-1001
Author(s):  
Wu Zeng ◽  
Betty Yuen Kwan Law ◽  
Vincent Kam Wai Wong ◽  
Denise So Bik Chan ◽  
Simon Wing Fai Mok ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Model ◽  
Antitumor Efficacy ◽  
P Glycoprotein ◽  
Brain Tumor Model
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