scholarly journals Luminal STAT5 mediates H2AX promoter activity in distinct population of basal mammary epithelial cells

Oncotarget ◽  
2016 ◽  
Vol 7 (27) ◽  
pp. 41781-41797 ◽  
Author(s):  
Moshe Reichenstein ◽  
Gat Rauner ◽  
Shenhav Kfir ◽  
Tatiana Kisliouk ◽  
Itamar Barash
Keyword(s):  
Epithelial Cells ◽  
Promoter Activity ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Distinct Population

Transient promoter activity in primary rat mammary epithelial cells evaluated using particle bombardment gene transfer

1993 ◽  
Vol 29 (2) ◽  
pp. 165-170 ◽  
Author(s):  
T. Anthony Thompson ◽  
Michael N. Gould ◽  
Joseph K. Burkholder ◽  
Ning-Sun Yang
Keyword(s):  
Gene Transfer ◽  
Epithelial Cells ◽  
Particle Bombardment ◽  
Promoter Activity ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial

scholarly journals p53 Stimulates Promoter Activity of thesgkSerum/Glucocorticoid-inducible Serine/Threonine Protein Kinase Gene in Rodent Mammary Epithelial Cells

1996 ◽  
Vol 271 (21) ◽  
pp. 12414-12422 ◽  
Author(s):  
Anita C. Maiyar ◽  
Arthur J. Huang ◽  
Phan T. Phu ◽  
Helen H. Cha ◽  
Gary L. Firestone
Keyword(s):  
Protein Kinase ◽  
Epithelial Cells ◽  
Promoter Activity ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Kinase Gene ◽  
Protein Kinase Gene

scholarly journals PI3K/AKT/mTOR Signaling Pathway Regulates MMP9 Gene Activation via Transcription Factor NF-κB in Mammary Epithelial Cells of Dairy Cows

2021 ◽  
Author(s):  
Yongjin Mao ◽  
Chen Su ◽  
Huilin Yang ◽  
Feng Zhao ◽  
Bo Qu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Dairy Cows ◽  
Signaling Pathway ◽  
Promoter Activity ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Promoter Assay ◽  
Mmp9 Expression

Abstract Background Matrix metalloproteinase 9 (MMP9) plays a pivotal role in mammary ductal morphogenesis, angiogenesis, and glandular tissue architecture remodeling. However, the molecular mechanism of MMP9 expression in mammary epithelial cells of dairy cows remains unclear. The current study aimed to explore the underlying mechanism of MMP9 expression. Results In this study, to determine whether the PI3K/AKT/mTOR/NF-κB signaling pathway participates in the regulation of MMP9 expression, we treated mammary epithelial cells with specific pharmacological inhibitors of PI3K (LY294002), mTOR (Rapamycin), or NF-κB (Celastrol), respectively. Western blotting results indicated that LY294002, Rapamycin, and Celastrol markedly decreased MMP9 expression and P65 nuclear translocation. Furthermore, we found that NF-κB (P65) overexpression resulted in elevated expression of MMP9 protein and activation of MMP9 promoter. In addition, we observed that Celastrol markedly decreases P65-overexpression-induced MMP9 promoter activity. Moreover, the results of the promoter assay indicated that the core regulation sequence for MMP9 promoter activation may be located -80bp to -420bp downstream from the transcription start site. Conclusions These observations indicated that the PI3K/AKT/mTOR signaling pathway is involved in MMP9 expression by regulating MMP9 promoter activity via NF-κB in the mammary epithelial cells of dairy cows.

Human mammary epithelial cells are sensitized to ionizing radiation by knockdown of caveolin-1

2010 ◽  
Vol 34 (8) ◽  
pp. S7-S7
Author(s):  
Nan Zhang ◽  
Jian Che ◽  
Zheng Wu ◽  
Yang Wang ◽  
Liwei Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Ionizing Radiation ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Caveolin 1 ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial

Microphysiometry to Evaluate Real-Time Response of Mammary Epithelial Cells to IGF-I

2000 ◽  
Vol 28 (1-2) ◽  
pp. 209-211 ◽  
Author(s):  
Rose Marie Robinson ◽  
R. Michael Akers ◽  
Kimberly E. Forsten
Keyword(s):  
Epithelial Cells ◽  
Real Time ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Time Response ◽  
Igf I
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