scholarly journals Constructing a pipeline for genome variant / gene functioning hybrid prioritization: a case study of type II diabetes

Author(s):  
Dr. Akshay H. Malshikare ◽  
Dr. Sharada Chikurte

Diabetes is a major health problem in whole world. In spite of many drugs available, uncontrolled diabetes remains a challenge. Moreover, some anti-diabetic drugs are on the verge of withdrawal due to its adverse effects. So, there is an acute need for a new effective and safe drug. So in this case study we used Ayurvedic medicine ‘Mustadi Kwatha’ mentioned in Bhaishajya Ratnawali in Prameha Chikitsa. A single case study was done on use of Mustadi Kwatha on Type II Diabetes Mellitus. Significant reduction was seen in blood sugar level fasting and post-prandial.


2020 ◽  
Author(s):  
Richard P Bartlett ◽  
Alexandria Watkins

UNSTRUCTURED Background: This is an outpatient case study that examines two patients in the United States with unique cases that involve oncology, hypertension, Type II Diabetes Mellitus, and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), also known as COVID-19. This case study involves two patients in the outpatient setting - treated via telemedicine, with laboratory-confirmed SARS-CoV-2 infection in the West Texas region between March 29th, 2020, and May 14th, 2020. Case Report: The first patient is a 63-year-old female, non-smoker, who is diagnosed with Waldenstrom’s Macroglobulinemia (2012) and Primary Cutaneous Marginal Zone Lymphoma (2020) and the second patient is a 38-year-old male, non-smoker, who has the following comorbidities: Type II Diabetes Mellitus (DM), hypertension, and gout. Both patients were empirically started on budesonide 0.5mg nebulizer twice daily, clarithromycin (Biaxin) 500mg tab twice daily for ten days, Zinc 50mg tab twice daily, and aspirin 81mg tab daily. Both patients have fully recovered with no residual effects. Conclusion: The goal is to call attention to the success of proactive, early empirical treatment, combining a classic corticosteroid (budesonide) administered via a nebulizer and an oral macrolide antibiotic known as clarithromycin (Biaxin).


Author(s):  
Ken Wei Tan ◽  
Joel R. Koo ◽  
Jue Tao Lim ◽  
Alex R. Cook ◽  
Borame L. Dickens

Chronic disease burdens continue to rise in highly dense urban environments where clustering of type II diabetes mellitus, acute myocardial infarction, stroke, or any combination of these three conditions is occurring. Many individuals suffering from these conditions will require longer-term care and access to clinics which specialize in managing their illness. With Singapore as a case study, we utilized census data in an agent-modeling approach at an individual level to estimate prevalence in 2020 and found high-risk clusters with >14,000 type II diabetes mellitus cases and 2000–2500 estimated stroke cases. For comorbidities, 10% of those with type II diabetes mellitus had a past acute myocardial infarction episode, while 6% had a past stroke. The western region of Singapore had the highest number of high-risk individuals at 173,000 with at least one chronic condition, followed by the east at 169,000 and the north with the least at 137,000. Such estimates can assist in healthcare resource planning, which requires these spatial distributions for evidence-based policymaking and to investigate why such heterogeneities exist. The methodologies presented can be utilized within any urban setting where census data exists.


Author(s):  
Anjali Mukerjee

It has been found that high prevalence of hypertension and Type II diabetes is coincidental to obesity. A well-defined nutrition therapy is one of the most effective methods of managing and slowing down the rate of development of Type II diabetes, gastrointestinal (GI) problems, and hypertension. A healthy diet or plan for the above-mentioned complications should be one that is naturally rich in phytochemicals and low in glycemic index, bad fats, and excess calories. This case study deals with the benefits of an “Integrated approach” in the management of diabetes, hypertension, gastric disorders, and obesity. The “integrated approach” includes patient-specific nutritional therapy, ayurvedic herb support, vitamins and dietary supplements, stress management, and regular exercise. The subject in this study was a 39-year-old obese female with a clinical history of Type II diabetes, borderline hypertension, and GI issues. Apart from these she also complained of low immunity, low energy levels, and high levels of stress. During the 10-month treatment, significant weight loss was achieved along with normalization of blood sugar levels and steady lowering of blood pressure with subsequent improvement in gastric problems and improved energy levels. Hence, the case report aptly illustrates that an integrated approach can help, not only manage diabetes, hypertension, and obesity but also reduce drug dosage and significantly improve quality of life.


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