scholarly journals The good genotype for clopidogrel metabolism is associated with decreased blood viscosity in clopidogrel-treated ischemic stroke patients

2020 ◽  
Vol 13 (2) ◽  
pp. 92-99
Author(s):  
Joong Hyun Park ◽  
Sang Won Han ◽  
Hyun-Jeung Yu
Keyword(s):  
Ischemic Stroke ◽  
Blood Viscosity ◽  
Stroke Patients

scholarly journals Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

2019 ◽  
Vol 26 (3-4) ◽  
pp. 30-34
Author(s):  
Al Rasyid ◽  
Salim Harris ◽  
Mohammad Kurniawan ◽  
Taufik Mesiano ◽  
Rakhmad Hidayat
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Blood Viscosity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Bivariate Analysis ◽  
Stroke Patients ◽  
Factors Affecting

Background: To assess the role of risk factors of metabolic syndrome on blood viscosity and the prognosis of acute ischemic stroke in Indonesia based on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Methods: This study included 135 patients with acute ischemic stroke. Patients underwent measurements of viscosity and risk factor assessment. Analysis was performed to assess the role of these risk factors for blood viscosity and outcomes of acute ischemic stroke with NIHSS and mRS as indicators. NIHSS was assessed at <3 days after onset and 7 days after onset, while mRS was assessed 1 month post treatment. Bivariate analysis was performed using chi-square test, and variables with p < 0.25 were further analyzed in multivariate analysis using logistic regression. Results: Factors affecting blood viscosity are fibrinogen, low-density lipoprotein (LDL), and hematocrit. Factors affecting NIHSS and mRS are fibrinogen and LDL. Conclusion: Fibrinogen and LDL affect the viscosity of blood and outcomes in acute ischemic stroke patients, so it is necessary to treat in the primary and secondary prevention of ischemic stroke.

scholarly journals BLOOD VISCOSITY AS A DETERMINING FACTOR OF ISCHEMIC STROKE OUTCOMES EVALUATED WITH NIHSS AND MRS ON DAY 7 AND 30 POST-THROMBOLYSIS

2019 ◽  
pp. 73-79
Author(s):  
Al Rasyid ◽  
Salim Harris ◽  
Mohammad Kurniawan ◽  
Taufik Mesiano ◽  
Rakhmad Hidayat ◽  
...  
Keyword(s):  
Emergency Department ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Blood Viscosity ◽  
Neurologic Deficit ◽  
National Institutes Of Health ◽  
Modified Rankin Scale ◽  
Stroke Patients ◽  
Stroke Outcomes ◽  
Determining Factor

Objective: This study aimed to analyze blood viscosity as a determining factor of ischemic stroke outcomes evaluated with National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) on day 7 and 30 post-thrombolysis. Methods: This study was a 4-months cohort study taking place in Cipto Mangunkusumo General Hospital from January to April 2017. Subjects were collected at the Emergency Department or Neurology Outpatient Department. Eligible patients gave informed consent. Patients underwent numerous examinations, including blood viscosity test using digital microcapillary (DM) instrument. Outcomes of patients were identified on day 7 and day 30 post-thrombolysis using NIHSS and mRS, respectively. Results: Most acute ischemic stroke patients (88.6%) had blood hyperviscosity. 9.1% patients had poorer neurologic deficit on day 7 evaluated with NIHSS and 18.2% patients had poor outcome on day 30 evaluated with mRS. All patients with normal blood viscosity did not have a poorer neurologic deficit on day-7-evaluation. Conclusion: Blood viscosity determines the outcomes of acute ischemic stroke patients on day 7 and day 30 post-thrombolysis.

Abstract TP234: New Clinical Application of Measurement of Blood Viscosity With an Electromagnetically Spinning Sphere Viscometer in Acute Ischemic Stroke Patients

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Takeo Abumiya ◽  
Koji Furukawa ◽  
Keiji Sakai ◽  
Miki Hirano ◽  
Toshiya Osanai ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Clinical Application ◽  
Blood Viscosity ◽  
Pathological Condition ◽  
Hematological Parameters ◽  
Vascular Diseases ◽  
Lacunar Infarction ◽  
Stroke Patients ◽  
Clinical Value

Introduction: Blood viscosity (BV) is an important blood property for determining the hemodynamic status. High BV causes blood stagnation and subsequent thrombotic reactions leading to cerebral infarction. However, clinical application of the measurement of BV is out of fashion due to the stereotype that the measurement results are within expectations with less clinical value. Hypothesis: Since the importance of BV remains unchanged in the pathogenesis of vascular diseases, BV values should still contain important information. We hypothesize that BV values may differ among stroke subtypes based on pathological condition. Methods: A new type of viscometer was recently developed using an electromagnetically spinning sphere (EMS) method, which enable us to measure small amount of samples quickly and sequentially in non-contact disposable manner. We measured BV in 100 healthy outpatients and 67 acute ischemic stroke patients (atherothrombotic: 28, lacunar: 23, and cardioembolic: 16) with EMS viscometer. The relationships between BV and hematological parameters were analyzed. The measurements in the acute stroke patients were performed a total of 4 times (Day0, Day2, Day7, and Day14 from the admission). Results: BV values in the healthy outpatients correlated more strongly with the total count of red blood cells and platelets (R2=0.6957) than with the hematocrit (R2=0.6435) in an exponential approximation. Compared with BV values in the healthy outpatients (4.57±0.76 mPa·s), Day0 BV values in the lacunar patients (5.37±1.11 mPa·s) were significantly higher (p<0.01), but those in the atherothrombotic patients (4.82±0.98 mPa·s) and in the cardioembolic patients (4.66±0.93 mPa·s) were not significantly different. In comparison between the values at Day 0 and Day 14, the lacunar patients alone showed a significant decrease from Day0 to Day14, suggesting that the lacunar patients suffered from dehydration at the onset. Conclusion: BV values at Day0 of lacunar infarction were significantly increased, which indicated contribution of dehydration to the onset of lacunar infarction. These measurements were performed with only 0.3ml of blood quickly and sequentially; therefore, the clinical application of the EMS viscometer appears to be promising.

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