BLOOD GROUP AND HUMAN DISEASES (REVIEW OF LITERATURE)

2020 ◽  
Vol 65 (4) ◽  
pp. 216-221
Author(s):  
Frida Nasyrovna Gilmiyarova ◽  
N. A. Kolotyeva ◽  
V. I. Kuzmicheva ◽  
O. A. Gusyakova ◽  
I. A. Borodina ◽  
...  
Keyword(s):  
Blood Group ◽  
Gastrointestinal Diseases ◽  
Antigenic Determinants ◽  
Blood Group Antigens ◽  
Oral Diseases ◽  
Group Type ◽  
Pathological Conditions ◽  
Definition Of ◽  
Meta Analyses

AB0 blood group antigens were discovered over a century ago; however, it is still important to study their role in development of various pathological conditions. Today it is known that antigenic determinants of this blood group are present not only on erythrocyte membrane but also on other cells and tissues: platelets, gastrointestinal epithelium and salivary glands, respiratory system cells. In the last decade, a large number of studies have appeared to reveal the relationship between a specific disease and blood group type, meta-analyses have been published. Previously, the authors have studied the metabolic status, cell composition and coagulation profile of clinically healthy individuals for more than on 180,000 donations, that allowed to identify group-specific features for each blood group. This review presents generalized data on the association of such pathological conditions as coronary heart disease, thromboembolic complications, tumors of various localizations, inflammatory and destructive oral diseases, psychiatric and some infectious diseases with the presence or absence of antigenic determinants A and B. Carriers of blood group 0 (I) are generally more resistant to diseases, with the exception of H.pylori-associated gastrointestinal diseases. Carriers of «antigenic» blood groups A (II), B (III), AB (IV) are more susceptible to development of infectious, cardiovascular and cancer diseases. The presented data demonstrate clinical significance of the definition of group typing not only for selection of blood and its components during transfusion and transplantation, but also for diagnostics, determination of risk group and tactics for treatment patients with different nosologies.

scholarly journals Role of Antigen Determinants a and B of AB0 Blood Group System in Human Disease Development (Mini Review)

2020 ◽  
Vol 3 (1) ◽  
pp. 39-43
Author(s):  
F.N. Gilmiyarova ◽  
V.I. Kuzmicheva ◽  
N.A. Kolotyeva ◽  
O.Yu. Kuznetsova
Keyword(s):  
Blood Group ◽  
Gastrointestinal Diseases ◽  
Antigenic Determinants ◽  
Epithelial Tissue ◽  
Blood Group System ◽  
Oral Diseases ◽  
Group System ◽  
Pathological Conditions ◽  
H Pylori

AbstractABO blood group system discovery was an important step in development of such areas as transplantation and transfusion medicine. At the same time understanding of fundamental role of antigenic determinants in physiological functions maintenance and pathological conditions development remained unexplained for a long time. Today it is known that A and B antigens are widely represented not only on erythrocytes membrane but also on other cells and tissues: platelets, epithelial tissue, oral and spermal fluids. Earlier authors studied metabolic and coagulation profiles, as well as blood cells composition in clinically healthy individuals on more than 180,000 donations, thus revealing group-specific features for each blood group. The review provides synthesis of association of such pathological conditions as coronary heart disease, thromboembolic complications, tumors of various localizations, inflammatory and destructive oral diseases, psychiatric and some infectious diseases with the presence or absence of antigenic determinants A and B. 0 (I) blood group carriers are more resistant to development of diseases, excepting H. pylori-associated gastrointestinal diseases. Carriers of “antigenic” blood groups A (II), B (III), AB (IV) are more susceptible to infections, cardiovascular diseases, and oncological diseases. The data presented may contribute to a personalized patient approach formation, based on antigen-associated biological variability of various signs in norm and pathology.

scholarly journals The Role of DNA Degradation in the Estimation of Post-Mortem Interval: A Systematic Review of the Current Literature

2020 ◽  
Vol 21 (10) ◽  
pp. 3540 ◽  
Author(s):  
Pamela Tozzo ◽  
Salvatore Scrivano ◽  
Matteo Sanavio ◽  
Luciana Caenazzo
Keyword(s):  
Analytical Techniques ◽  
Dna Degradation ◽  
Post Mortem ◽  
Post Mortem Interval ◽  
Target Organs ◽  
The One ◽  
Definition Of ◽  
Meta Analyses

The determination of the post-mortal interval (PMI) is an extremely discussed topic in the literature and of deep forensic interest, for which various types of methods have been proposed. The aim of the manuscript is to provide a review of the studies on the post-mortem DNA degradation used for estimating PMI. This review has been performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the PRISMA Guidelines. Several analytical techniques have been proposed to analyse the post-mortem DNA degradation in order to use it to estimate the PMI. Studies focused mainly on animal models and on particular tissues. The results have been mixed: while on the one hand literature data in this field have confirmed that in the post-mortem several degradation processes involve nucleic acids, on the other hand some fundamental aspects are still little explored: the influence of ante and post-mortem factors on DNA degradation, the feasibility and applicability of a multiparametric mathematical model that takes into account DNA degradation and the definition of one or more target organs in order to standardize the results on human cases under standard conditions.

Determination of homozygote vs heterozygote of Rh blood group antigens via rosette assays

Transfusion ◽  
1982 ◽  
Vol 22 (3) ◽  
pp. 194-196 ◽  
Author(s):  
AB Loren ◽  
Y Matsuo ◽  
D Charman ◽  
MM Yokoyama
Keyword(s):  
Blood Group ◽  
Blood Group Antigens ◽  
Rh Blood Group

scholarly journals Identification of Aptamers that Specifically Bind to A1 Antigen by Performing Cell-on Human Erythrocytes

2020 ◽  
Vol 9 ◽  
pp. 1657
Author(s):  
Seyed Mohammad Hasan Hosseini ◽  
Mohammad Reza Bassami ◽  
Alireza Haghparast ◽  
Mojtaba Sankian ◽  
Gholamreza Hashemi Tabar
Keyword(s):  
Blood Group ◽  
Dna Aptamer ◽  
Diagnostic Tools ◽  
Blood Group Antigens ◽  
Apparent Dissociation Constant ◽  
Fluorescent Intensity ◽  
Target Molecules ◽  
Polymerase Chain ◽  
Dissociation Constant Kd

Background: The apply of aptamers as a new generation’s way to probe diagnostic for the detection of target molecules has gained ground. Aptamers can be used as alternatives to diagnostic antibodies for detection of blood groups due to their unique features. This study was aimed to produce DNA diagnostic aptamer detecting the antigen of A1 blood group using the Cell-Selex method. Materials and Methods: DNA aptamer was isolated against A1 RBC antigen after ten stages of Cell-Selex and amplification by an asymmetric polymerase chain reaction. The progress of the stages of selection was evaluated using flow cytometry analysis, which the DNA aptamer isolated from the tenth cycle with an affinity of 70% fluorescent intensity, was selected from four positive colonies followed by determination of the sequences and secondary structures. Results: The aptameric sequence obtained from C4 cloning was calculated with the highest binding affinity to A1 antigen having an apparent dissociation constant (Kd value) of at least 29.5 ± 4.3 Pmol, which was introduced as the selected aptamer-based on ΔG obtained from a colony of C4 equal to –13.13. Conclusion: The aptamer obtained from using Cell-Selex method could be used as an example for the development of diagnostic tools such as biosensors for detecting A1 blood group antigens. [GMJ.2020;9:e1657] 

Synthesis of ABO Histo-Blood Group Type V and VI Antigens

2009 ◽  
Vol 62 (6) ◽  
pp. 558 ◽  
Author(s):  
Peter J. Meloncelli ◽  
Todd L. Lowary
Keyword(s):  
Chemical Synthesis ◽  
Enzyme Kinetics ◽  
Blood Group ◽  
Solid Support ◽  
Blood Group Antigens ◽  
Detailed Understanding ◽  
Group Type ◽  
Kinetics Studies ◽  
Blood Group Type ◽  
Type V

The ABO histo-blood group antigens have long been of interest to chemists, biochemists, and evolutionary biologists. However, to date, a complete synthesis of all ABO histo-blood group antigens has not been conducted, despite the potential for such a panel to provide a more detailed understanding of the biological roles of these glycan motifs. Here we report the chemical synthesis of the A, B, and H type V and VI antigens in multi-milligramme quantities as part of an overall goal to prepare all 18 A, B, and H antigens. The A and B type V and VI antigens were prepared with a 7-octen-1-yl linker, to enable future conjugation to a protein or solid support. The H type V and VI antigens were prepared as the octyl glycoside, to facilitate detailed enzyme kinetics studies.

scholarly journals Structure determination of blood group type glycolipids of cat small intestine by mass fragmentography

FEBS Letters ◽  
1978 ◽  
Vol 89 (1) ◽  
pp. 42-46 ◽  
Author(s):  
Michael E. Breimer ◽  
Gunnar C. Hansson ◽  
Karl-Anders Karlsson ◽  
Hakon Leffler ◽  
Weston Pimlott ◽  
...  
Keyword(s):  
Small Intestine ◽  
Blood Group ◽  
Structure Determination ◽  
Mass Fragmentography ◽  
Group Type ◽  
Blood Group Type
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