scholarly journals Impact of Ionizing Radiation on the Expression of CDC25A Phosphatase (in vivo)

2016 ◽  
Vol 10 (5) ◽  
pp. 22-26 ◽  
Author(s):  
Seyed Mostafa Mir ◽  
Esmaeil Samadian ◽  
Sahar Alijanpour ◽  
Alireza Khoshbin Khoshnazar ◽  
Hamid Haghighatfard ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Cdc25a Phosphatase

THE SYNERGISTIC EFFECT OF LASER RADIATION AND IONIZING RADIATION ON MALIGNANT TUMORS IN VIVO AND IN VITRO

1967 ◽  
Vol 99 (2) ◽  
pp. 446-449 ◽  
Author(s):  
JAMES T. HELSPER ◽  
GEORGE S. SHARP ◽  
DONALD E. ROUNDS
Keyword(s):  
Laser Radiation ◽  
Ionizing Radiation ◽  
Synergistic Effect ◽  
Malignant Tumors

scholarly journals Offset of apparent hyperpolarized 13 C lactate flux by the use of adjuvant metformin in ionizing radiation therapy in vivo

2021 ◽  
Author(s):  
Young‐Suk Choi ◽  
Joonsung Lee ◽  
Han‐Sol Lee ◽  
Jae Eun Song ◽  
Dong‐Hyun Kim ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Ionizing Radiation

scholarly journals In Vivo Study of the Efficacy and Safety of 5-Aminolevulinic Radiodynamic Therapy for Glioblastoma Fractionated Radiotherapy

2021 ◽  
Vol 22 (18) ◽  
pp. 9762
Author(s):  
Junko Takahashi ◽  
Shinsuke Nagasawa ◽  
Motomichi Doi ◽  
Masamichi Takahashi ◽  
Yoshitaka Narita ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Aminolevulinic Acid ◽  
Combined Treatment ◽  
Reactive Oxygen Species Generation ◽  
Photodynamic Diagnosis ◽  
High Dose ◽  
Severe Toxicity ◽  
Fractionated Radiotherapy ◽  
Post Surgery

To treat malignant glioma, standard fractionated radiotherapy (RT; 60 Gy/30 fractions over 6 weeks) was performed post-surgery in combination with temozolomide to improve overall survival. Malignant glioblastoma recurrence rate is extremely high, and most recurrent tumors originate from the excision cavity in the high-dose irradiation region. In our previous study, protoporphyrin IX physicochemically enhanced reactive oxygen species generation by ionizing radiation and combined treatment with 5-aminolevulinic acid (5-ALA) and ionizing radiation, while radiodynamic therapy (RDT) improved tumor growth suppression in vivo in a melanoma mouse model. We examined the effect of 5-ALA RDT on the standard fractionated RT protocol using U251MG- or U87MG-bearing mice. 5-ALA was orally administered at 60 or 120 mg/kg, 4 h prior to irradiation. In both models, combined treatment with 5-ALA slowed tumor progression and promoted regression compared to treatment with ionizing radiation alone. The standard fractionated RT protocol of 60 Gy in 30 fractions with oral administration of 120 and 240 mg/kg 5-ALA, the human equivalent dose of photodynamic diagnosis, revealed no significant increase in toxicity to normal skin or brain tissue compared to ionizing radiation alone. Thus, RDT is expected to enhance RT treatment of glioblastoma without severe toxicity under clinically feasible conditions.

Reduced Apoptosis and Increased Deletion Mutations at Aprt Locus In vivo in Mice Exposed to Repeated Ionizing Radiation

2007 ◽  
Vol 67 (5) ◽  
pp. 1910-1917 ◽  
Author(s):  
Li Liang ◽  
Marc S. Mendonca ◽  
Li Deng ◽  
Son C. Nguyen ◽  
Changshun Shao ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Deletion Mutations

IN VIVO MUTATIONS IN HUMAN T-CELLS AFTER IONIZING RADIATION EXPOSURES

1992 ◽  
pp. 326-331
Author(s):  
R.J. Albertini ◽  
J.P. O'Neill ◽  
J.A. Nicklas
Keyword(s):  
T Cells ◽  
Ionizing Radiation ◽  
Human T Cells

scholarly journals High-throughput preparation of radioprotective polymers via Hantzsch’s reaction for in vivo X-ray damage determination

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Guoqiang Liu ◽  
Yuan Zeng ◽  
Tong Lv ◽  
Tengfei Mao ◽  
Yen Wei ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
High Throughput ◽  
Water Soluble ◽  
Mechanistic Study ◽  
Initial Attempt ◽  
Water Soluble Polymer ◽  
X Ray ◽  
In Vivo Experiments ◽  
Acute Injuries

AbstractRadioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch’s reaction, high-throughput methods and polymer chemistry. A water-soluble polymer with low-cytotoxicity and an excellent anti-radiation capability has been achieved. In in vivo experiments, this polymer is even better than amifostine, which is the only approved radioprotector for clinical applications, in effectively protecting zebrafish embryos from fatally large doses of ionizing radiation (80 Gy X-ray). A mechanistic study also reveals that the radioprotective ability of this polymer originates from its ability to efficiently prevent DNA damage due to high doses of radiation. This is an initial attempt to explore polymer radioprotectors via a multi-component reaction. It allows exploiting functional polymers and provides the underlying insights to guide the design of radioprotective polymers.

scholarly journals βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1

2019 ◽  
Vol 27 (4) ◽  
pp. 1200-1213 ◽  
Author(s):  
Ainhoa Nieto ◽  
Makoto R. Hara ◽  
Victor Quereda ◽  
Wayne Grant ◽  
Vanessa Saunders ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Strand Break ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Molecular Scaffold ◽  
Strand Breaks

Abstract Cellular DNA is constantly under threat from internal and external insults, consequently multiple pathways have evolved to maintain chromosomal fidelity. Our previous studies revealed that chronic stress, mediated by continuous stimulation of the β2-adrenergic-βarrestin-1 signaling axis suppresses activity of the tumor suppressor p53 and impairs genomic integrity. In this pathway, βarrestin-1 (βarr1) acts as a molecular scaffold to promote the binding and degradation of p53 by the E3-ubiquitin ligase, MDM2. We sought to determine whether βarr1 plays additional roles in the repair of DNA damage. Here we demonstrate that in mice βarr1 interacts with p53-binding protein 1 (53BP1) with major consequences for the repair of DNA double-strand breaks. 53BP1 is a principle component of the DNA damage response, and when recruited to the site of double-strand breaks in DNA, 53BP1 plays an important role coordinating repair of these toxic lesions. Here, we report that βarr1 directs 53BP1 degradation by acting as a scaffold for the E3-ubiquitin ligase Rad18. Consequently, knockdown of βarr1 stabilizes 53BP1 augmenting the number of 53BP1 DNA damage repair foci following exposure to ionizing radiation. Accordingly, βarr1 loss leads to a marked increase in irradiation resistance both in cells and in vivo. Thus, βarr1 is an important regulator of double strand break repair, and disruption of the βarr1/53BP1 interaction offers an attractive strategy to protect cells against high levels of exposure to ionizing radiation.

Therapeutic ionizing radiation induced bone loss: a review of in vivo and in vitro findings

2018 ◽  
Vol 59 (6) ◽  
pp. 509-522 ◽  
Author(s):  
Jian Zhang ◽  
Xinyu Qiu ◽  
Kedi Xi ◽  
Wentao Hu ◽  
Hailong Pei ◽  
...  
Keyword(s):  
Bone Loss ◽  
Ionizing Radiation ◽  
Radiation Induced
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