scholarly journals Genetic Polymorphisms of CYP2C19 and Resistance to Clopidogrel Therapy among Iranian Patients Suffering from Ischemic Heart Disease

2016 ◽  
Vol 4 (3) ◽  
pp. 41-46 ◽  
Author(s):  
Behzad Poopak ◽  
Maed Heidari ◽  
Parviz Fallah ◽  
Nazila Safari ◽  
Saghar Rabieipoor ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genetic Polymorphisms ◽  
Ischemic Heart ◽  
Clopidogrel Therapy ◽  
Iranian Patients

Cytochrome 2C19 and paraoxonase-1 polymorphisms and clopidogrel resistance in ischemic heart disease patients

2019 ◽  
Vol 16 (5) ◽  
pp. 379-386
Author(s):  
Nabila Akram ◽  
Ghulam Mustafa ◽  
Anum A Hanif ◽  
Shahzad Tawwab ◽  
Shabbir Hussain ◽  
...  
Keyword(s):  
Heart Disease ◽  
Platelet Aggregation ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Paraoxonase 1 ◽  
Loss Of Function ◽  
Pakistani Population ◽  
Clopidogrel Resistance ◽  
Pcr Rflp ◽  
Clopidogrel Therapy

Aim: Polymorphisms in cytochrome P450 (CYP) 2C19 and paraoxonase-1 (PON-1) genes are thought to be involved in clopidogrel high on treatment reactivity in ischemic heart disease (IHD) patients. Methods: A total of 240 patients with IHD were screened for CYP2C19 loss-of-function alleles (LOF; *2, *3) and PON-1 Q192R. Patients were classified as responders and nonresponders to clopidogrel based upon platelet aggregation studies. Genotyping of the CYP2C19 and PON-1 allele was carried out by PCR-RFLP. Results: Results showed that 14.3% of the patients were nonresponders, whereas 85.7% were responders to the clopidogrel therapy. CYP2C19*3 allele showed significant association with clopidogrel high on treatment reactivity in IHD patients. Conclusion: Result of our study demonstrate that IHD patients with CYP2C19*3 allele can face the problem of clopidogrel high on treatment reactivity in Punjabi Pakistani population.

scholarly journals Genetic Polymorphisms and Ischemic Heart Disease

2017 ◽  
Author(s):  
Francesco Fedele ◽  
Mariateresa Pucci ◽  
Paolo Severino
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genetic Polymorphisms ◽  
Ischemic Heart

scholarly journals Association of genetic polymorphisms in the ace, apoe, and tgfβ genes with early onset ischemic heart disease

1998 ◽  
Vol 21 (11) ◽  
pp. 831-836 ◽  
Author(s):  
S. Biggart ◽  
Mrcp, D. Chin ◽  
M. Fauchon ◽  
G. Cardew ◽  
L. Du Fou ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genetic Polymorphisms ◽  
Early Onset ◽  
Ischemic Heart

Genetic score based on high-risk genetic polymorphisms and early onset of ischemic heart disease in an Italian cohort of ischemic patients

2014 ◽  
Vol 133 (5) ◽  
pp. 804-810 ◽  
Author(s):  
Cecilia Vecoli ◽  
Daniel Adlerstein ◽  
Erlet Shehi ◽  
Federico Bigazzi ◽  
Tiziana Sampietro ◽  
...  
Keyword(s):  
Heart Disease ◽  
High Risk ◽  
Ischemic Heart Disease ◽  
Genetic Polymorphisms ◽  
Early Onset ◽  
Ischemic Heart ◽  
Genetic Score ◽  
Italian Cohort

Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease

2012 ◽  
Vol 223 (2) ◽  
pp. 409-415 ◽  
Author(s):  
Maria Grazia Andreassi ◽  
Daniel Adlerstein ◽  
Clara Carpeggiani ◽  
Erlet Shehi ◽  
Sonia Fantinato ◽  
...  
Keyword(s):  
Heart Disease ◽  
High Risk ◽  
Ischemic Heart Disease ◽  
Genetic Polymorphisms ◽  
Cardiovascular Events ◽  
Ischemic Heart
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