New Composite Endpoints to Assess Efficacy in Periodontal Therapy Clinical Trials

2006 ◽  
Vol 77 (8) ◽  
pp. 1314-1322 ◽  
Author(s):  
Samuel E. Lynch ◽  
Philip T. Lavin ◽  
Robert J Genco ◽  
William G. Beasley ◽  
Leslie A. Wisner-Lynch
Keyword(s):  
Clinical Trials ◽  
Periodontal Therapy ◽  
Composite Endpoints

scholarly journals Salvadora persica: Nature’s Gift for Periodontal Health

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 712
Author(s):  
Mohamed Mekhemar ◽  
Mathias Geib ◽  
Manoj Kumar ◽  
Radha ◽  
Yasmine Hassan ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Periodontal Therapy ◽  
Periodontal Treatment ◽  
Oral Disease ◽  
Salvadora Persica ◽  
Periodontal Health ◽  
Clinical Investigations ◽  
Therapeutic Mechanisms ◽  
Pharmacologic Actions

Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects. Numerous investigations have studied the pharmacologic actions of SP in oral disease therapies but its promising outcomes in periodontal health and treatment are not yet entirely described. The current study has been planned to analyze the reported effects of SP as a support to periodontal therapy to indorse regeneration and healing. In consort with clinical trials, in vitro investigations show the advantageous outcomes of SP adjunctive to periodontal treatment. Yet, comprehensive supplementary preclinical and clinical investigations at molecular and cellular levels are indispensable to reveal the exact therapeutic mechanisms of SP and its elements for periodontal health and therapy.

scholarly journals Bio-Inspired Systems in Nonsurgical Periodontal Therapy to Reduce Contaminated Aerosol during COVID-19: A Comprehensive and Bibliometric Review

2020 ◽  
Vol 9 (12) ◽  
pp. 3914
Author(s):  
Andrea Butera ◽  
Carolina Maiorani ◽  
Valentino Natoli ◽  
Ambra Bruni ◽  
Carmen Coscione ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Bacterial Load ◽  
Periodontal Therapy ◽  
Clinical Practices ◽  
Immunological Parameters ◽  
Aerosol Generation ◽  
Global Pandemic ◽  
Probing Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Bibliometric Review

Background: On 30 January 2020, a public health emergency of international concern was declared as a result of the new COVID-19 disease, caused by the SARS-CoV-2 virus. This virus is transmitted by air and, therefore, clinical practices with the production of contaminant aerosols are highly at risk. The purpose of this review was to assess the effectiveness of bio-inspired systems, as adjuvants to nonsurgical periodontal therapy, in order to formulate bio-inspired protocols aimed at restoring optimal condition, reducing bacteremia and aerosols generation. Methods: A comprehensive and bibliometric review of articles published in English. Research of clinical trials (RCTs) were included with participants with chronic or aggressive periodontal disease, that have compared benefits for nonsurgical periodontal therapy (NSPT). Results: Seventy-four articles have been included. For probing depth (PPD) there was a statically significant improvement in laser, probiotic, chlorhexidine groups, such as gain in clinical attachment level (CAL). Bleeding on probing (BOP) reduction was statistically significant only for probiotic and chlorhexidine groups. There were changes in microbiological and immunological parameters. Conclusions: The use of bio-inspired systems in nonsurgical periodontal treatment may be useful in reducing risk of bacteremia and aerosol generation, improving clinical, microbiological and immunological parameters, of fundamental importance in a context of global pandemic, where the reduction of bacterial load in aerosols becomes a pivotal point of clinical practice, but other clinical trials are necessary to achieve statistical validity.

scholarly journals Reporting quality and spin in abstracts of randomized clinical trials of periodontal therapy and cardiovascular disease outcomes

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0230843 ◽  
Author(s):  
Murad Shaqman ◽  
Khadijeh Al-Abedalla ◽  
Julie Wagner ◽  
Helen Swede ◽  
John Cart Gunsolley ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Reporting Quality ◽  
Periodontal Therapy ◽  
Disease Outcomes

Composite Endpoints in Clinical Trials

2005 ◽  
pp. 1-6
Author(s):  
Peter C. O'Brien ◽  
Barbara C. Tilley ◽  
Peter J. Dyck
Keyword(s):  
Clinical Trials ◽  
Composite Endpoints

scholarly journals Periodontal Therapy for Improving Lipid Profiles in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 20 (15) ◽  
pp. 3826 ◽  
Author(s):  
Siddharth Garde ◽  
Rahena Akhter ◽  
Mai Anh Nguyen ◽  
Clara K. Chow ◽  
Joerg Eberhard
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Clinical Trials ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profiles ◽  
Periodontal Therapy ◽  
Inflammatory Disorder

Periodontitis is a chronic inflammatory disorder often seen in patients with diabetes mellitus (DM). Individuals with diabetes are at a greater risk of developing cardiovascular complications and this may be related, in part, to lipid abnormalities observed in these individuals. The objective of this systematic review is to compile the current scientific evidence of the effects of periodontal treatment on lipid profiles in patients with type 2 diabetes mellitus. Through a systematic search using MEDLINE, EMBASE, PubMed, and Web of Science, 313 articles were identified. Of these, seven clinical trials which met all inclusion criteria were chosen for analysis. Between baseline and 3-month follow-up, there was a statistically significant reduction in the levels of total cholesterol (mean differences (MD) −0.47 mmol/L (95% confidence interval (CI), −0.75, −0.18, p = 0.001)), triglycerides (MD −0.20 mmol/L (95% CI −0.24, −0.16, p < 0.00001)) favouring the intervention arm, and a statistically significant reduction in levels of high density lipoprotein (HDL) (MD 0.06 mmol/L (95% CI 0.03, 0.08, p < 0.00001)) favouring the control arm. No significant differences were observed between baseline and 6-month follow-up levels for any lipid analysed. The heterogeneity between studies was high. This review foreshadows a potential benefit of periodontal therapy for lipid profiles in patients suffering from type 2 DM, however, well designed clinical trials using lipid profiles as primary outcome measures are warranted.

Clinical trials in periodontal therapy

1987 ◽  
Vol 22 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Jan Lindhe ◽  
Stare Nyman
Keyword(s):  
Clinical Trials ◽  
Periodontal Therapy

Periodontal Abscess during Supportive Periodontal Therapy: A Review of the Literature

2008 ◽  
Vol 9 (6) ◽  
pp. 82-91 ◽  
Author(s):  
Geraldo L. M. Silva ◽  
Rodrigo V. Soares ◽  
Elton G. Zenóbio
Keyword(s):  
Clinical Trials ◽  
Single Case ◽  
Accurate Diagnosis ◽  
Periodontal Therapy ◽  
Current Status ◽  
Periodontal Pathogens ◽  
Review Of The Literature ◽  
High Susceptibility ◽  
Adequate Treatment ◽  
Supportive Periodontal Therapy

Aim The aim of this review is to present the current status of the occurrence and management of a periodontal abscess during supportive periodontal therapy (SPT). Background A periodontal abscess depicts typical features and has been described in patients under SPT in clinical trials. Common periodontal pathogens have been observed in this lesion and some etiologic factors may be responsible for its recurrence. This condition can be isolated or associated with factors that can change the prognosis of affected teeth. Review Results Although it has been frequently noticed in untreated periodontitis, the periodontal abscess can also occur in patients under SPT and has been regarded as one of the possible complications of SPT. Patients with a high susceptibility to periodontal disease lost more teeth than those with a healthy periodontium. Conclusion Early diagnosis and appropriate intervention for periodontal abscesses in patients under SPT are extremely important for the management of the periodontal abscess since this condition can lead to loss of the involved tooth. A single case of a tooth diagnosed with periodontal abscess that responds favorably to adequate treatment does not seem to affect its longevity. Clinical Significance An accurate diagnosis and adequate treatment can preserve the longevity of affected teeth. Citation Silva GLM, Soares RV, Zenóbio EG. Periodontal Abscess during Supportive Periodontal Therapy: A Review of the Literature. J Contemp Dent Pract 2008 September; (9)6:082-091.

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