scholarly journals Enamel remineralisation-inducing materials for caries prevention

2021 ◽  
Vol 54 (3) ◽  
pp. 165
Author(s):  
Sri Kunarti ◽  
Widya Saraswati ◽  
Dur Muhammad Lashari ◽  
Nadhifa Salma ◽  
Tasya Nafatila
Keyword(s):  
Calcium Phosphate ◽  
Dental Caries ◽  
Tricalcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Caries Prevention ◽  
Multifactorial Disease ◽  
Dental Tissue ◽  
Carious Lesions ◽  
Caries Management ◽  
Casein Phosphopeptide

Background: Dental caries is a multifactorial disease indicated by the progressive demineralisation process of dental tissue. It is caused by an imbalance between the remineralisation and demineralisation processes. The focus of caries management is on prevention. Providing materials that can induce remineralisation is one management of caries prevention. Various materials have been or are being researched, such as casein phosphopeptide amorphous calcium phosphate (CPP–ACP), tricalcium phosphate (fTCP), bioactive glass (BAG), and nanotechnologies such as nano-hydroxyapatite (n-HAP) and silver nano fluorine (NSF). Purpose: This study aims to review the development of enamel remineralisation inducing materials as a newer approach in caries prevention. Review: Various ingredients have been shown to increase enamel remineralisation through different mechanisms in preventing the development of carious lesions. Conclusion: CPP–ACP, fTCP, BAG, n-HAP, and NSF can induce enamel remineralisation as caries prevention agents. n-HAP and NSF are the most effective agents to enhance enamel remineralisation to prevent caries.

scholarly journals Reversal of Root Caries with Casein Phosphopeptide-Amorphous Calcium Phosphate and Fluoride Varnish in Xerostomia

2021 ◽  
pp. 1-10
Author(s):  
Ahmed Sleibi ◽  
Anwar R. Tappuni ◽  
Aylin Baysan
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Primary Root ◽  
Severity Index ◽  
Salivary Flow ◽  
Root Caries ◽  
Carious Lesions ◽  
Group 2 ◽  
Casein Phosphopeptide ◽  
Group 1

Different formulas of topical fluoride have been used to manage root carious lesions. This clinical trial aimed to investigate the efficacy of a dental varnish containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride compared with fluoride alone in reversing/arresting root caries in xerostomic patients over 1 year. A total of 80 patients (age range 45–92 years) with primary root caries (<i>n</i> = 184 root carious lesions) and unstimulated salivary flow rate of &#x3c;0.2 mL/min were randomly allocated to receive either dental varnish containing CPP-ACP and 5% fluoride (group 1: MI varnish; GC, Japan) (<i>n</i> = 41, 83 lesions), or dental varnish with 5% fluoride alone (group 2: NUPRO White; Dentsply, USA) (<i>n</i> = 39, 101 lesions). Clinical assessments with Severity Index (SI) for root caries, DIAGNOdent measurements, and varnish application were carried out at baseline, 3, 6, and 12 months. Standard oral hygiene instructions with 1,450 ppm fluoride toothpastes were provided for both groups. After 3 months, 63.9% (<i>n</i> = 46) of root caries in group 1 became hard (SI: 0) compared with 39.3% (<i>n</i> = 35) in group 2 (<i>p</i> &#x3c; 0.01). After 6 and 12 months, the differences in SI were insignificant (group 1, <i>n</i> = 60, 83.3%) (group 2, <i>n</i> = 66, 74.2%) (<i>p</i> = 0.36), and (group 1, <i>n</i> = 60, 89.6%) (group 2, <i>n</i> = 67, 81.7%, <i>n</i> = 1 soft, 1.2%) (<i>p</i> = 0.29), respectively. In both groups, noncavitated leathery lesions were more likely to become hard when compared to the cavitated root caries. A significant decrease in plaque index, surface roughness, lesion dimension, and DIAGNOdent readings with a significant increase in lesion distance from the gingival margin was reported in both groups (<i>p</i> &#x3c; 0.05). This study has provided evidence that fluoride dental varnish either with or without calcium and phosphate has the potential to arrest/reverse root caries, especially noncavitated lesions for patients with xerostomia.

In vitro comparison of the remineralizing effect of casein phosphopeptide-amorphous calcium phosphate and fluoride varnish on early carious lesions

2019 ◽  
Vol 11 (1) ◽  
pp. 45 ◽  
Author(s):  
Rafael Morales-Vadillo ◽  
Janet-Ofelia Guevara-Canales ◽  
Hugo-Percy García-Rivera ◽  
Rosario-Haydée Bazán-Asencios ◽  
José-Martín Robello-Malatto ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Fluoride Varnish ◽  
Carious Lesions ◽  
Casein Phosphopeptide ◽  
In Vitro Comparison

scholarly journals Prevention of dental caries with remineralization in containing Casein Phosphopeptid-Amorphous Calcium Phosphate (CPP-ACP) to students SD Swasta Muhammadiyah – 03 Medan

2019 ◽  
Vol 4 (2) ◽  
pp. 439-443
Author(s):  
Fitri Yunita Batubara ◽  
M. Zulkarnain ◽  
Cut Nurliza ◽  
Nurdiana ◽  
Dewi Kartika
Keyword(s):  
Calcium Phosphate ◽  
Dental Caries ◽  
Primary School ◽  
Community Service ◽  
Amorphous Calcium Phosphate ◽  
Caries Prevention ◽  
School Age ◽  
High Caries Risk ◽  
Grade Ii ◽  
The Impact

Dental caries is an infectious disease caused by demineralization of enamel and dentin which is closely related to the consumption of cariogenic foods. Generally children entering school age have a high caries risk, because at this school age children usually like food and drink snacks as they wish. The impact that occurs when since the beginning has experienced caries is in addition to the function of the teeth as chewing that is disrupted, swollen gums, the child will also experience disturbances in carrying out their daily activities, so the child will not eat and consequently malnutrition can occur, this causes the child to be unable to study because of lack of concentration so that it will affect intelligence. The results of the field analysis and preliminary interviews with school leaders as partners in community service obtained data that students in Muhammadiyah Private Elementary School 03 Medan aged 6-8 years experienced dental caries with the characteristics of cavities, porous, and stains / plaques. These characteristics are related to the patterns or behavior of students who like to consume sweet foods like candy, bread, and chocolate. School Dental Health Efforts (UKGS) have also not been implemented in schools. Therefore, community service is needed to be carried out with a form of socialization prevention for early caries in order to provide knowledge of the main causes, ways of spreading, impact, efforts to prevent dental caries, and providing remineralization (dental caries prevention) containing Casein Phosphopeptid-Amorphous Calcium Phosphate (CPP-ACP) to students of grade II Muhammadiyah Primary School 03 Medan. Community service activities were carried out by five service teams from the Faculty of Dentistry, University of North Sumatra on August 27, 2019, involving as many as twenty two USU FKG students who were undergoing clinical clerkship. The socialization and provision of caries prevention materials to 111 students who were in grade II of Muhammadiyah Primary School - 03 Medan.

scholarly journals Randomized Controlled Study to Evaluate Microbial Ecological Effects of CPP-ACP and Cranberry on Dental Plaque

2019 ◽  
Vol 5 (2) ◽  
pp. 118-126
Author(s):  
N. Philip ◽  
S.J. Leishman ◽  
H.M.H.N. Bandara ◽  
D.L. Healey ◽  
L.J. Walsh
Keyword(s):  
Randomized Controlled Trial ◽  
Calcium Phosphate ◽  
Dental Caries ◽  
Amorphous Calcium Phosphate ◽  
Dental Plaque ◽  
Controlled Trial ◽  
Bacterial Species ◽  
Oral Microbiome ◽  
Randomized Controlled ◽  
Casein Phosphopeptide

Introduction: Ecological approaches to dental caries prevention play a key role in attaining long-term control over the disease and maintaining a symbiotic oral microbiome. Objectives: This study aimed to investigate the microbial ecological effects of 2 interventional dentifrices: a casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) dentifrice and the same dentifrice supplemented with a polyphenol-rich cranberry extract. Methods: The interventional toothpastes were compared with each other and with an active control fluoride dentifrice in a double-blinded randomized controlled trial. Real-time quantitative polymerase chain reaction (qPCR) analysis was used to determine changes in the bacterial loads of 14 key bacterial species (8 caries associated and 6 health associated) in the dental plaque of trial participants after they used the dentifrices for 5 to 6 wk. Results: From the baseline to the recall visit, significant differences were observed between the treatment groups in the bacterial loads of 2 caries-associated bacterial species ( Streptococcus mutans [ P < 0.001] and Veillonella parvula [ P < 0.001]) and 3 health-associated bacterial species ( Corynebacterium durum [P = 0.008], Neisseria flavescens [ P = 0.005], and Streptococcus sanguinis [ P < 0.001]). Compared to the fluoride control dentifrice, the CPP-ACP dentifrice demonstrated significant differences for S. mutans ( P = 0.032), C. durum ( P = 0.007), and S. sanguinis ( P < 0.001), while combination CPP-ACP–cranberry dentifrice showed significant differences for S. mutans ( P < 0.001), V. parvula ( P < 0.001), N. flavescens ( P = 0.003), and S. sanguinis ( P < 0.001). However, no significant differences were observed in the bacterial load comparisons between the CPP-ACP and combination dentifrices for any of the targeted bacterial species ( P > 0.05). Conclusions: Overall, the results indicate that dentifrices containing CPP-ACP and polyphenol-rich cranberry extracts can influence a species-level shift in the ecology of the oral microbiome, resulting in a microbial community less associated with dental caries (Australian New Zealand Clinical Trial Registry ANZCTR 12618000095268). Knowledge Transfer Statement: The results of this randomized controlled trial indicate that dentifrices containing casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) and polyphenol-rich cranberry extracts were able to beneficially modulate the microbial ecology of dental plaque in a group of high caries-risk patients. This could contribute toward lowering the risk of developing new caries lesions, an important goal sought by patients, clinicians, and policy makers.

Is there a role for casein phosphopeptide–amorphous calcium phosphate (cpp-acp) in paediatric dentistry?

Dental Update ◽  
2021 ◽  
Vol 48 (2) ◽  
pp. 127-132
Author(s):  
Claire Warner ◽  
Helen J Rogers
Keyword(s):  
Calcium Phosphate ◽  
Dental Caries ◽  
Amorphous Calcium Phosphate ◽  
Tooth Surface ◽  
Orthodontic Appliances ◽  
Dentine Hypersensitivity ◽  
Carious Tooth ◽  
Surface Loss ◽  
Casein Phosphopeptide ◽  
Structural Anomalies

In the age of minimally invasive dentistry, products with the ability to prevent and reverse common dental diseases are becoming increasingly popular. Casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) contains the compounds casein, phosphate and calcium, which all have the ability to remineralize enamel. Dental caries, visible demineralization following removal of orthodontic appliances, non-carious tooth surface loss and dentine hypersensitivity due to structural anomalies are frequently seen in children and young people. The evidence for CPP–ACP and fluoride-containing CPP–ACP is positive for managing dental caries and non-carious tooth surface loss, specifically erosion, but is less clear in the management of visible demineralization following orthodontic appliance removal and dentine hypersensitivity owing to structural anomalies. When recommending CPP–ACP-containing products, dental practitioners should be aware of medical and social contra-indications that preclude its use. CPD/Clinical Relevance: CPP–ACP may have a role in the management of common paediatric dental conditions.

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