Based on structural equation model, this paper evaluated the effect of Service-Learning in E-business professional curriculum, and built a structural equation model of Service-Learning and its influencing factors from three aspects: project resource, teaching organization and student engagement,in order to understand the students satisfaction to the effect of Service-Learning and the relevant factors. The results show that, the effect of Service-Learning is influenced by the three aspects mentioned above. Among which, teaching organization and student engagement have a direct effect on the effect of Service-Learning, however, the influence of the project resource mainly displays the indirect influence.