scholarly journals Effect of Natural Functional Mixture on the Descent of Blood Glucose Level in Streptozotocin-Induced Diabetic(type I) Rats(Ⅱ)

2011 ◽  
Vol 17 (1) ◽  
pp. 239-248
Author(s):  
Donghwa Son ◽  
김대곤 ◽  
이수진
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type I ◽  
Diabetic Type

scholarly journals Optimal regulation of blood glucose level in Type I diabetes using insulin and glucagon

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213665 ◽  
Author(s):  
Afroza Shirin ◽  
Fabio Della Rossa ◽  
Isaac Klickstein ◽  
John Russell ◽  
Francesco Sorrentino
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type I Diabetes ◽  
Type I ◽  
Optimal Regulation

Co-Microencapsulation of BMSCs and Mouse Pancreatic (3 Cells for Improving the Efficacy of Type I Diabetes Therapy

2017 ◽  
Vol 40 (4) ◽  
pp. 169-175 ◽  
Author(s):  
Ruimin Long ◽  
Yuangang Liu ◽  
Shibin Wang ◽  
Li Ye ◽  
Peng He
Keyword(s):  
Stem Cells ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type I Diabetes ◽  
Insulin Injection ◽  
Primary Study ◽  
Type I ◽  
Glucose Determination

Introduction To overcome the shortcomings of pancreas transplantation and insulin injection treatment for type I diabetes, biocompatible materials were used to prepare alginate-chitosan-alginate microcapsules that co-encapsulated bone marrow mesenchymal stem cells and mouse pancreatic β cells to treat diabetic mice. Methods Blank alginate-chitosan-alginate (ACA) microcapsules and co-microencapsulated cells were prepared using a high-voltage electrostatic method and then characterized using an inverted microscope. Cell viability was evaluated using AO/EB staining. ELISA kit was used to detect insulin secretion. Peri-orbital blood samples were obtained from the mice for blood glucose determination every week for one month. Results After 28 days of in vitro culture, the secretion of insulin following co-microencapsulation was higher than that observed for microencapsulated beta-TC-6 cells alone. On the 28th day after transplantation, the blood glucose level was 6.86 mmol/L in the microencapsulated beta-TC-6 group. On the 14th day, the blood glucose level was 6.80 mmol/L in the co-microencapsulated BMSC/beta-TC-6 group, which was close to the normal blood glucose level of healthy mice. These results indicated that the efficacy in reducing blood glucose was better in the co-microencapsulated BMSC/beta-TC-6 group. Conclusions This primary study indicated that combining microencapsulation technology and co-culture of stem cells and somatic cells shows promise for the treatment of type I diabetes mellitus.

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