Effect of Non-sterilized Makgeolli Consumption on Blood Glucose Level and Survival Rate in Streptozotocin-induced Type I Diabetic Mice

2015 ◽  
Vol 30 (6) ◽  
pp. 818-824
Author(s):  
Hyun Sook Lee ◽  
◽  
Soon Mi Kim
Keyword(s):  
Blood Glucose ◽  
Survival Rate ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Type I ◽  
Diabetic Mice

The Effects of Soyferment-Tempeh on Lipid Profile, Retinol-Binding Protein 4 (RBP4), and Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression in Type 2 Diabetic Mice

2021 ◽  
pp. 193-200
Author(s):  
Prasetyastuti Prasetyastuti ◽  
Dian Setiawan Ghozali
Keyword(s):  
Gene Expression ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Glucose Level ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Retinol Binding Protein ◽  
Atherogenic Index ◽  
Diabetic Mice

Diabetes Type 2 can cause oxidative stress leading to the accumulation of reactive oxygen species. Soyferment-Tempeh, a fermented soybean product with aerobic and anaerobic R. oligosporus incubation has a high antioxidant content of isoflavones that can regulate oxidative stress in diabetes. In this study, we evaluate the effects of Soyferment-Tempeh on lipid profile, Retinol-Binding Protein 4 (RBP4), and Phosphoenolpyruvate Carboxykinase (PEPCK) gene expression in type 2 diabetic mice. A total of 30 mice with the age of eight weeks were divided into six groups as follows: A) nondiabetic, B) diabetic mice, C) diabetic mice with metformin, D), E), and F) diabetic mice with Soyferment-Tempeh doses of 10, 20, or 40mg/100g body weight (BW), respectively, were administered treatments orally by gavages. Blood was collected for assessment of blood glucose level, and lipid profile before and after 3 weeks of the administration. After sacrificing the mice, livers were used for RBP4 and PEPCK gene expression assessment. Supplementation with three different doses of Soyferment-Tempeh in streptozotocin-induced diabetic mice for 21 days significantly (p<0.001) reduced blood glucose level, total cholesterol, triglycerides, low-density lipoprotein level, atherogenic index, and increased high-density lipoprotein level. There was a significant decrease in RBP4 gene expression in the Soyferment-Tempeh of dose 10mg/100g BW treatment groups (p<0.05), while the PEPCK gene expression did not significantly differ (p>0.05). These results demonstrate that supplementation with Soyferment-Tempeh decreases blood glucose level, atherogenic index, improves lipid profile, and decreases RBP4.

scholarly journals Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

2015 ◽  
Vol 38 (4) ◽  
pp. 629-633 ◽  
Author(s):  
Hiroko Uchida-Maruki ◽  
Hiroyuki Inagaki ◽  
Ryouichi Ito ◽  
Ikuko Kurita ◽  
Masahiko Sai ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Mice

scholarly journals Hypoglycemic Effect of Scarlet Spiral Flag (Costus woodsonii) to Alloxan-Induced Diabetic Mice: An In Vivo Study

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Roderic John R. Magtulis ◽  
Emvie Loyd P. Itable, RN, MAN
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Alloxan Monohydrate

<p class="AbstractContent"><strong>Objective:</strong> Diabetes Mellitus is a leading illness to the society and despite of a lot of researches, not a single cure has been discovered. Most of the time, people focused on fighting diabetes and medicinal plants were utilized. The purpose of this study was to investigate the hypoglycemic effect of Scarlet Spiral Flag (<em>Costus woodsonii</em>) and to be reviewed for preclinical trials.</p><p class="AbstractContent"><strong>Methods: </strong>20 male Swiss mice were made diabetic by inducing Alloxan monohydrate. Then separated randomly into 4 groups with different treatments administered daily for 7 days; Control, Positive Control (600 µg/kg Glibenclamide), T1 (250mg/kg Scarlet Spiral Flag ethanolic extract) and T2 (500mg/kg Scarlet Spiral Flag ethanolic extract). Their blood sugar was monitored onset after 1<sup>st</sup> treatment (6<sup>th</sup>, 12<sup>th</sup> and 24<sup>th</sup> hours) and during the week within the 1<sup>st</sup>, 4<sup>th</sup> and 8<sup>th</sup> day.</p><p class="AbstractContent"><strong>Results:</strong> Both the onset and fasting blood sugar monitoring showed a significant decrease in the mean average blood glucose level of the mice.<strong></strong></p><p class="AbstractContent"><strong>Conclusion: </strong>The ethanolic extract of Scarlet Spiral Flag (<em>Costus woodsonii</em>) has a potent antidiabetic effect in Alloxan-induced diabetic mice. Since it is under the same Genus of the Insulin plant, it has a common effect in terms of lowering the blood glucose level.</p><p class="AbstractContent"><strong>Keywords: </strong>Acclimatization, Alloxan, <em>Costus woodsonii, </em>Ethanolic Extract, Oral Gavage</p>

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