scholarly journals The Ghrelin Receptor (Ghsr) Gene Polymorphism in Indonesian Local Chicken and Crossbreed Is Associated With Carcass Traits

2018 ◽  
Vol 19 (2) ◽  
pp. 71
Author(s):  
Isyana Khaerunnisa ◽  
Jakaria Jakaria ◽  
Irma Isnafia Arief ◽  
Cahyo Budiman ◽  
Cece Sumantri
Keyword(s):  
Growth Hormone ◽  
Gene Polymorphism ◽  
Candidate Gene ◽  
Carcass Traits ◽  
Carcass Composition ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor ◽  
Chicken Carcass ◽  
Parent Stock ◽  
Local Chicken

Ghrelin receptor (GHSR) gene is candidate gene for growth performance in chicken by modulating growth hormone release from the pituitary by binding to its ligand of ghrelin. Ghrelin gene, or growth hormone secretagogue (GHS) gene, is well known as feed intake and energy homeostasis regulator in mammals and birds. The objectives of this study were to identify the polymorphism of the T1857C GHSR locus in Indonesian local chicken and to evaluate its effects on carcass traits. The gene polymorphism was identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using Hin6I restriction enzyme. Effect of genotype on carcass composition was analyzed using SAS General Linear Model (GLM) procedure. The genotyping was performed on 343 individuals including Merawang, Pelung, Sentul, Kampung, broiler (strain Cobb, parent stock), F1 crossbred of Kampung x broiler (strain Cobb, parent stock), and F2 crossbred of Kampung x broiler (strain Cobb, parent stock). All individuals were successfully amplified and were resulted in a 470 bp PCR product. This locus was polymorphic with two alleles (T and C) and three genotypes (TT, CT, and CC). The T allele and TT genotype were predominant in all populations. Individuals with CT genotype were significantly had higher live weight at 26w, carcass weight, commercial cuts weights, and muscles weights than TT genotype in F2 crossbred of Kampung x broiler population. Association of the T1857C GHSR locus-polymorphism with chicken carcass composition has been described in Indonesian chicken, providing evidence that GHSR might be an important candidate gene for chicken carcass traits.

scholarly journals Genetic Linkage and Association of the Growth Hormone Secretagogue Receptor (Ghrelin Receptor) Gene in Human Obesity

Diabetes ◽  
2004 ◽  
Vol 54 (1) ◽  
pp. 259-267 ◽  
Author(s):  
A. Baessler ◽  
M. J. Hasinoff ◽  
M. Fischer ◽  
W. Reinhard ◽  
G. E. Sonnenberg ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Genetic Linkage ◽  
Receptor Gene ◽  
Human Obesity ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor

scholarly journals LEAP-2: An Emerging Endogenous Ghrelin Receptor Antagonist in the Pathophysiology of Obesity

2021 ◽  
Vol 12 ◽  
Author(s):  
Xuehan Lu ◽  
Lili Huang ◽  
Zhengxiang Huang ◽  
Dandan Feng ◽  
Richard J. Clark ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Energy Balance ◽  
Food Intake ◽  
Antimicrobial Peptide ◽  
Molar Ratio ◽  
Positive Energy ◽  
Energy Status ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor

Liver-expressed antimicrobial peptide 2 (LEAP-2), originally described as an antimicrobial peptide, has recently been recognized as an endogenous blocker of growth hormone secretagogue receptor 1a (GHS-R1a). GHS-R1a, also known as ghrelin receptor, is a G protein-coupled receptor (GPCR) widely distributed on the hypothalamus and pituitary gland where it exerts its major functions of regulating appetite and growth hormone (GH) secretion. The activity of GHS-R1a is controlled by two counter-regulatory endogenous ligands: Ghrelin (activation) and LEAP-2 (inhibition). Ghrelin activates GHS-R1a on the neuropeptide Y/Agouti-related protein (NPY/AgRP) neurons at the arcuate nucleus (ARC) to promote appetite, and on the pituitary somatotrophs to stimulate GH release. On the flip side, LEAP-2, acts both as an endogenous competitive antagonist of ghrelin and an inverse agonist of constitutive GHS-R1a activity. Such a biological property of LEAP-2 vigorously blocks ghrelin’s effects on food intake and hormonal secretion. In circulation, LEAP-2 displays an inverse pattern as to ghrelin; it increases with food intake and obesity (positive energy balance), whereas decreases upon fasting and weight loss (negative energy balance). Thus, the LEAP-2/ghrelin molar ratio fluctuates in response to energy status and modulation of this ratio conversely influences energy intake. Inhibiting ghrelin’s activity has shown beneficial effects on obesity in preclinical experiments, which sheds light on LEAP-2’s anti-obesity potential. In this review, we will analyze LEAP-2’s effects from a metabolic point of view with a focus on metabolic hormones (e.g., ghrelin, GH, and insulin), and discuss LEAP-2’s potential as a promising therapeutic target for obesity.

Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation

2008 ◽  
Vol 18 (6) ◽  
pp. 2203-2205 ◽  
Author(s):  
Jason Witherington ◽  
Lee Abberley ◽  
Michael A. Briggs ◽  
Katharine Collis ◽  
David K. Dean ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor ◽  
Lead Optimisation
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