scholarly journals Synthesis, Characterisation, Antimicrobial activity and DNA Cleavage of (E)-2-((Tetrazolo[1,5-A]Quinolin-4- ylmethylene)Amino)Phenol Schiff base Metal complexes

2020 ◽  
Vol 13 (2) ◽  
pp. 29-37
Author(s):  
Anilkumar Ambala ◽  
Ch. Abraham Lincoln
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Dna Cleavage ◽  
Analytical Data ◽  
Amino Phenol ◽  
Ft Ir ◽  
Uv Visible ◽  
Schiff Base Metal Complexes

A series of novel (E)-2-((Tetrazolo[1,5-a]quinolin-4-ylmethylene)amino)phenol Cu(II), Co(II), Ni(II), Zn(II) and Mn (II) metal complexes have been synthesized 1:1 metal to ligand ratio, and these complexes were characterized by using analytical data such as FT-IR, UV-visible, Mass spectroscopy, SEM, EDX, TGA and magnetic moment measurements. The ligand and all the metal complexes were tested in vitro antimicrobial activity and DNA cleavage studies.

scholarly journals Synthesis, Spectral and Antimicrobial Studies of Some Co(II), Ni(II) and Cu(II) Complexes Containing 2-Thiophenecarboxaldehyde Moiety

2012 ◽  
Vol 9 (3) ◽  
pp. 1113-1121 ◽  
Author(s):  
A. P. Mishra ◽  
A. Tiwari ◽  
S. K. Gupta ◽  
Rajendra Jain
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Antimicrobial Agents ◽  
Analytical Data ◽  
Molar Conductance ◽  
E Coli ◽  
Antimicrobial Studies ◽  
Degradation Pattern ◽  
Ft Ir ◽  
Schiff Base Metal Complexes

Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 3-chloro-4-fluoroaniline (HL1) and 4-fluoroaniline (HL2) with 2-thiophenecarboxaldehyde have been synthesized and characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ESR and magnetic susceptibility. The complexes exhibit coordination number 4 or 6. The complexes are colored and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal: ligand) ratio. FAB-mass data show degradation pattern of the complexes. The Schiff base and metal complexes show a good activity against the bacteria;B. subtilis,E. coliandS. aureusand fungiA. niger,A. flavusandC. albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

scholarly journals Synthesis, Characterization, Antimicrobial, DNA Cleavage, andIn VitroCytotoxic Studies of Some Metal Complexes of Schiff Base Ligand Derived from Thiazole and Quinoline Moiety

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Nagesh Gunvanthrao Yernale ◽  
Mruthyunjayaswamy Bennikallu Hire Mathada
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Biological Activities ◽  
Artemia Salina ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Pyramidal Geometry

A novel Schiff base ligandN-(4-phenylthiazol-2yl)-2-((2-thiaxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarboxamide(L)obtained by the condensation ofN-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 2-thioxo-1,2-dihydroquinoline-3-carbaldehyde and its newly synthesized Cu(II), Co(II), Ni(II), and Zn(II) complexes have been characterized by elemental analysis and various spectral studies like FT-IR,1H NMR, ESI mass, UV-Visible, ESR, TGA/DTA, and powder X-ray diffraction studies. The Schiff base ligand(L)behaves as tridentate ONS donor and forms the complexes of type [ML(Cl)2] with square pyramidal geometry. The Schiff base ligand(L)and its metal complexes have been screenedin vitrofor their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activity of ligand and its metal complexes were studied using plasmid DNA pBR322 as a target molecule by gel electrophoresis method. The brine shrimp bioassay was also carried out to study thein vitrocytotoxicity properties for the ligand and its metal complexes againstArtemia salina. The results showed that the biological activities of the ligand were found to be increased on complexation.

scholarly journals Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

2020 ◽  
pp. 68-68
Author(s):  
Pravinkumar Patil ◽  
Sainath Zangade
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Cytotoxic Activity ◽  
Anticancer Agents ◽  
Cancer Cell Line ◽  
Artemia Salina ◽  
Carbonyl Oxygen ◽  
Planar Geometry ◽  
Ft Ir

A series of binary metal complexes [halo, hydroxyl and methoxy sub-stituted bis (2-(E) acryloyl)naphthalen-1-yl)oxy)Cu(II) and Zn(II) (C1-C10)] of Cu2+ and Zn2+ ions derived from bi-coordinated hydroxylated 1,3-diaryl-2- -propene-1-ones were synthesized. The newly synthesized metal complexes were structurally determined by FT-IR, 1H NMR, 13CNMR, ESR spectral, XRD and TGA analysis. The FT-IR and ESR studies demonstrated that interactions between metal ions with ligands occur through carbonyl oxygen and deprotonated hydroxyl oxygen and corresponds to square-planar geometry for all complexes. In-vitro the metal complexes were screened and evaluated for their antimicrobial and cytotoxic activity. The complexes C1 and C4 showed the significant antimicrobial activity while the remaining complexes were showed the moderately antimicrobial activity against the tested pathogens. The complexes were evaluated for cytotoxic activity against the organism Artemia salina. The complexes C2, C3, C4 and C5 were showed the LC50 values as 630.45, 969.99, 921.94 and 918.41 ?M mL-1 respectively. Further complexes were evaluated for anticancer activity against liver cancer cell line (Hep G2) in comparison with 5-fluorouracil standard. The complex C5 showed the significant IC50 value 58.94 ?g mL-1. Therefore the present study is useful to develop the new class of antimicrobial and anticancer agents.

scholarly journals Antitumor and Antimicrobial Potential of Manganese(II), Nickel(II) and Copper(II) Complexes of 4-Methoxy Benzohydrazide Derived Schiff Base Ligand

2021 ◽  
Vol 11 (1) ◽  
pp. 3249-3260
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Antimicrobial Activities ◽  
Molar Ratio ◽  
Gram Positive Bacteria ◽  
Ft Ir ◽  
Dose Dependent

Herein, we describe the synthesis and characterization of a Schiff base ligand (E)-N'-(2-hydroxybenzylidene)-4-methoxybenzohydrazide (HBMB) and its Mn(II), Ni(II), and Cu(II) metal complexes (C1-C3) respectively. The ligand HBMB was synthesized by reacting condensation of salicylaldehyde and 4-methoxy benzohydrazide in a 1:1 molar ratio. The structure of HBMB and its metal complexes (C1-C3) were evaluated by using UV-Vis, FT-IR, 1H-NMR, mass spectroscopy as well as on the basis of elemental analysis, conductivity measurements, and thermogravimetric techniques (TGA). The synthesized molecules' tumoricidal properties were performed against human breast cancer (MCF-7) and colon cancer (HT 29) cell lines. The biological results indicated that the ligand, HBMB, and metal complexes possess dose-dependent selective cytotoxicity against the tested carcinoma cells. The synthesized compounds were further evaluated for their in vitro antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli), and fungal strains (Aspergillus niger).

scholarly journals Synthesis, Spectral Characterization and Biological Evaluation of Schiff Base Metal Complexes Derived from Aniline Derivative

2019 ◽  
Vol 31 (9) ◽  
pp. 2095-2100
Author(s):  
P. Priya ◽  
S. Vedanayaki ◽  
P. Jayaseelan
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Magnetic Measurements ◽  
Antioxidant Activities ◽  
Analytical Data ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Aniline Derivative ◽  
Schiff Base Metal Complexes

A new Schiff base ligand (L) N-(4-fluorophenyl)-1-(4-(((4-fluorophenyl)imino)methyl)phenyl)- methaninmine was prepared by the condensation of terephthalaldehyde with 4-fluoroaniline in 1:2 molar ratio. The mononuclear complexes of Co(II), Ni(II), Cu(II) and Zn(II) (1-4) have been synthesized in (2:1) ligand to metal ratio. The composition, geometry and binding sites of ligand with metal complexes were evidenced by various spectral methods like molar conductance, elemental analytical data, magnetic measurements, UV-visible, 1H & 13C NMR, ESI-MS, FT-IR, ESR and thermal analysis. The above studies shows that the ligand is a bidentate and its metal complexes possess an octahedral geometry. Oxidative cleavage of DNA studies of the complexes were monitored by super helix PUC18DNA using a method of agarose gel electrophoresis. Ligand and its metal complexes were screened against gram positive (Staphylococcus aureus), gram negative (Klebsiella pneumoniae) bacterium and fungus (Candida albicans) strains. Antioxidant activities of the metal complexes possess greater activity than ligand.

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