scholarly journals Secoiridoids from the Seed of Gonocaryum calleryanum and Their Inhibitory Potential on LPS-Induced Tumor Necrosis Factor and Nitric Oxide Production

2018 ◽  
Author(s):  
Kun-Ching Cheng ◽  
Chi-I Chang ◽  
Yu-Chi Lin ◽  
Chih-I Liu ◽  
Yu-Ci Zeng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
2D Nmr ◽  
Inflammatory Agent ◽  
Mouse Macrophages ◽  
Dependent Inhibition ◽  
Inhibitory Potential ◽  
Necrosis Factor ◽  
New Metabolites

Three new secoiridoid constituents Gonocarin A-C (1-3) and a new derivative Gonocarin A monoacetate (4), along with two known lignins pinoresinol (5) and paulownin (6) were isolated from the seed of Gonocaryum calleryanum (Baill.) Becc. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. When mouse macrophages RAW264.7 were treated with compounds 1-6 together with LPS -stimulated, a concentration-dependent inhibition of nitric oxide (NO) and tumor necrosis factor (TNF-α) productions were detected. The results confirmed that the Gonocaryum calleryanumrrg could be a potential anti-inflammatory agent.

Potent Cytotoxic Lignans fromJusticiaprocumbensand Their Effects on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages

2002 ◽  
Vol 65 (3) ◽  
pp. 379-381 ◽  
Author(s):  
Shiow-Hwa Day ◽  
Yi-Chen Lin ◽  
Mei-Lin Tsai ◽  
Lo-Ti Tsao ◽  
Horng-Huey Ko ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Mouse Macrophages ◽  
Factor Α ◽  
Necrosis Factor
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