scholarly journals The Role of Archaic Human Genes in the Current Epidemic of Diabetes Mellitus in Indigenous Australians

2018 ◽  
Author(s):  
Malgorzata Brzozowska ◽  
Richard Allen
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Selection ◽  
Modern Human ◽  
Indigenous Australians ◽  
Genetic Studies ◽  
Obesity And Diabetes ◽  
Human Genes ◽  
Ancient Gene

Indigenous Australians have been particularly affected by type 2 diabetes mellitus due to their genetic susceptibility and a range of environmental risk factors. Recent genetic studies link predisposition to some diseases, including diabetes, to archaic humans, such as Neanderthals and Denisovans, suggesting persistence of ancient alleles in the genomes of modern humans. In this review we discuss the evolutionary role of the negative genetic selection associated with an adopted Western lifestyle as well as DNA variants influencing predisposition to obesity and diabetes in the Australian Indigenous population. We review the contribution of the ancient gene/pathways to the modern human phenotypes including the Neanderthal haplotype-tagging SNPs in NTRK2 gene, which may continue to play a role in obesity in Indigenous Australians.

scholarly journals The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2

2019 ◽  
Vol 22 (3) ◽  
pp. 253-262
Author(s):  
Elena V. Pokrovskaya ◽  
Minara S. Shamkhalova ◽  
Marina V. Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Gut Microbiota ◽  
Human Body ◽  
Diabetes Mellitus Type 2 ◽  
Metabolic Disorders ◽  
Developed Countries ◽  
Diabetes Mellitus Type ◽  
Obesity And Diabetes

Obesity is a worldwide problem of the last century, the prevalence of which has reached pandemic proportions in developed countries. Over the past few years, a considerable amount of data has been gathered, reporting a direct link between changes in gut microbiota and the development of obesity, as well as related diseases, primarily, diabetes mellitus type 2. The elaboration of optimal methods of prevention and treatment regimens of these diseases needs to structure the existing knowledge about the mechanisms of development of metabolic disorders, the role of intestinal microbiota in the latter and possible therapeutic targets. This review examines the role of microorganisms in the human body, with the main focus on the developmental origins of metabolic disorders using animal models and accumulated experience of research on their effects on the human body, and also discusses possible treatment options, including bariatric surgery, fecal microbiota transplantation, the use of pre- and probiotics and certain particular groups of glucose-lowering drugs.

scholarly journals The Role of Sleep Curtailment on Leptin Levels in Obesity and Diabetes Mellitus

Obesity Facts ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 214-221
Author(s):  
Maryam Mosavat ◽  
Mitra Mirsanjari ◽  
Diana Arabiat ◽  
Aisling Smyth ◽  
Lisa Whitehead
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Food Intake ◽  
Sleep Deprivation ◽  
Sleep Duration ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Obesity And Diabetes

Emerging evidence has identified sleep as a significant, but modifiable, risk factor for metabolic syndrome, diabetes, and obesity. Leptin, an adipocyte-derived peptide and a regulator of food intake and energy expenditure, has been shown to be associated with a short sleep duration in the pathophysiology of obesity and consequently type 2 diabetes. This review focuses on the current evidence indicating the effects of a short sleep duration on the regulation of leptin concentration in association with obesity and diabetes mellitus. In summary, the evidence suggests that sleep deprivation, by affecting leptin regulation, may lead to obesity and consequently development of type 2 diabetes through increased appetite and food intake. However, findings on the role of leptin in diabetes due to sleep deprivation are contradictory, and further studies with larger sample sizes are needed to confirm previous findings.

Role of Vitamin C in Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus Introduction

2020 ◽  
Vol 11 (2) ◽  
pp. 1701
Author(s):  
Nermien Abd El Rahman Ibraheim ◽  
Fatema El Zahraa Sayed Bukhary ◽  
Yehia Zakareia Mahmoud ◽  
Mahmoud Ragab Mohamed ◽  
Salama Rabei Abdel-Rahim
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Vitamin C

The GSTM1 and GSTT1 Null Genotypes Increase the Risk for Type 2 Diabetes Mellitus and the Subsequent Development of Diabetic Complications: A Meta-analysis

2018 ◽  
Vol 15 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Sayantan Nath ◽  
Sambuddha Das ◽  
Aditi Bhowmik ◽  
Sankar Kumar Ghosh ◽  
Yashmin Choudhury
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Meta Analysis ◽  
Subsequent Development ◽  
Asian Population ◽  
Gstm1 Null Genotype ◽  
Increased Risk

Background:Studies pertaining to association of GSTM1 and GSTT1 null genotypes with risk of T2DM and its complications were often inconclusive, thus spurring the present study.Methods:Meta-analysis of 25 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in determining the risk for T2DM and 17 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in development of T2DM related complications were conducted.Results:Our study revealed an association between GSTM1 and GSTT1 null polymorphism with T2DM (GSTM1; OR=1.37;95% CI =1.10-1.70 and GSTT1; OR=1.29;95% CI =1.04-1.61) with an amplified risk of 2.02 fold for combined GSTM1-GSTT1 null genotypes. Furthermore, the GSTT1 null (OR=1.56;95%CI=1.38-1.77) and combined GSTM1-GSTT1 null genotypes (OR=1.91;95%CI=1.25- 2.94) increased the risk for development of T2DM related complications, but not the GSTM1 null genotype. Stratified analyses based on ethnicity revealed GSTM1 and GSTT1 null genotypes increase the risk for T2DM in both Caucasians and Asians, with Asians showing much higher risk of T2DM complications than Caucasians for the same. </P><P> Discussion: GSTM1, GSTT1 and combined GSTM1-GSTT1 null polymorphism may be associated with increased risk for T2DM; while GSTT1 and combined GSTM1-GSTT1 null polymorphism may increase the risk of subsequent development of T2DM complications with Asian population carrying an amplified risk for the polymorphism.Conclusion:Thus GSTM1 and GSTT1 null genotypes increases the risk for Type 2 diabetes mellitus alone, in combination or with regards to ethnicity.

Role of Yoga in Lifestyle Disorders w.s.r. to Diabetes Mellitus Type-2

2019 ◽  
Vol 4 (03) ◽  
Author(s):  
Tushar K. Pardeshi ◽  
Sachinkumar Patil
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 2 ◽  
Healthy Lifestyle ◽  
Working Hours ◽  
Behavioral Pattern ◽  
Current Trends ◽  
Diet Pattern ◽  
Speed And Accuracy

21st century is full of stress requiring more speed and accuracy. In today’s world of competition, diet pattern, lifestyle and behavioral pattern of people has changed. Late working hours, deadlines of work and stress have become a parcel of daily life. Due to this people have won’t have time for exercise and Yoga and end up in various lifestyle disorder, like Diabetes mellitus, Dyslipidemia, Obesity, Cardiovascular diseases etc. Diabetes mellitus is one of most leading disorder in all of them. The worldwide prevalence of D.M. has raised dramatically over past two decades, from an estimated 30 million cases in 1985 to 177 million in 2000. Based on current trends, > 360 million individuals will have diabetes by the year 2030. Diabetes mellitus is mentioned in our Samhitas as disorder of lethargic and exercise less lifestyle disorder and termed it as Madhumeha. Caused by mainly Apathyaahara and Viharsevana. Chikitsa of Madhumeha focused on Pathyaaahara and Vihar (lifestyle) in management of Madhumeha. This article is deal with healthy lifestyle including Yoga mentioned in Ayurveda Samhita for management of prevention and treatment of Lifestyle disorders.

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