scholarly journals 3-(3,5-Difluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

2018 ◽  
Author(s):  
Naveen Kumar ◽  
Swamy Sreenivasa ◽  
Vasantha Kumar ◽  
Nadigar Revansiddappa Mohan
Keyword(s):  
Spectral Analysis ◽  
13C Nmr ◽  
Title Compound ◽  
Structure Characterization ◽  
Dimethyl Formamide ◽  
The Novel ◽  
Mass Spectral Analysis ◽  
Mass Spectral ◽  
Phosphorous Oxychloride

Vilsmeier–Haack reaction of (E)-1-(1-(3,5-difluorophenyl)ethylidene)-2-phenylhydrazine (1) using dimethyl formamide in excess of phosphorous oxychloride by conventional method, resulted in the synthesis of title compound 3-(3,5-difluorophenyl)-1-phenyl-1H-pyrazole-4- carbaldehyde (2) in good yield and high purity. Structure characterization of the novel title compound was done by IR, 1H NMR, 13C NMR and mass spectral analysis.

scholarly journals 3-(3,5-Difluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Molbank ◽  
10.3390/m1011 ◽  
2018 ◽  
Vol 2018 (3) ◽  
pp. M1011 ◽  
Author(s):  
Naveen Kumar ◽  
Swamy Sreenivasa ◽  
Vasantha Kumar ◽  
Nadigar Mohan
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
High Purity ◽  
Title Compound ◽  
Good Yield ◽  
Phosphorus Oxychloride ◽  
Structure Characterization ◽  
Dimethyl Formamide

Vilsmeier–Haack reaction of (E)-1-[1-(3,5-difluorophenyl)ethylidene]-2-phenylhydrazine (1) using dimethyl formamide in excess of phosphorus oxychloride by conventional method, resulted in the synthesis of the title compound 3-(3,5-difluorophenyl)-1-phenyl-1H-pyrazole-4- carbaldehyde (2) in good yield and high purity. Structure characterization of the title compound was done by IR, 1H-NMR, 13C-NMR and HRMS spectral analysis.

scholarly journals 1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole

Molbank ◽  
10.3390/m1023 ◽  
2018 ◽  
Vol 2018 (4) ◽  
pp. M1023 ◽  
Author(s):  
Jean Guillon ◽  
Solène Savrimoutou ◽  
Sandra Rubio ◽  
Vanessa Desplat
Keyword(s):  
Spectral Analysis ◽  
Cell Lines ◽  
13C Nmr ◽  
Title Compound ◽  
Indole Derivative ◽  
Leukemia Cell ◽  
Structure Characterization ◽  
Cytotoxic Potential ◽  
Leukemia Cell Lines

The 1-methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole compound has been successfully synthesized via a multistep pathway starting from 2-phenylindole. Structure characterization of this new indole derivative was done by FTIR, 1H-NMR, 13C-NMR, and HRMS spectral analysis. The title compound showed high cytotoxic potential against five leukemia cell lines (K562, HL60, U937, U266, and Jurkat cell lines).

1,2,4-triazoles Clubbed Pyrimidine Compounds with Synthesis, Antimicrobial, Antituberculosis, Antimalarial, and Anti-protozoal Studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Navin B. Patel ◽  
Hetal I. Soni ◽  
Rahul B. Parmar ◽  
Manuel J. Chan-Bacab ◽  
Gildardo Rivera
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
Antifungal Agent ◽  
New Products ◽  
Antifungal Drugs ◽  
Bioactive Molecules ◽  
Mass Spectral Analysis ◽  
Mass Spectral

: Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best examples of antifungal drugs available in the market, which consist an active triazole moiety. Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial, an-tituberculosis, antimalarial, and anti-protozoal. N-[4-(substituted phenyl)-6-(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3A-J) were synthesized by different method as cyclization, condensation, purification and crystallization. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and anti-protozoal activities. These com-pounds satisfied the bioactive response and simple way for the synthesis.

scholarly journals Ureido Derivatives of Neoabietic Acid

Molbank ◽  
10.3390/m1033 ◽  
2018 ◽  
Vol 2018 (4) ◽  
pp. M1033
Author(s):  
Xinyu Gao ◽  
Niping Feng ◽  
Yuhan Zi ◽  
Jianguo Cao ◽  
Guozheng Huang
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
Structure Characterization ◽  
Curtius Rearrangement ◽  
Neoabietic Acid ◽  
Rearrangement Reaction ◽  
Derivatives Of

A series of ureido derivatives of neoabietic acid were synthesized by application of Curtius rearrangement reaction to neoabietic acid and amines. Structure characterization of these compounds was done by 1H-NMR, 13C-NMR and HRMS spectral analysis.

scholarly journals Proof for the biosynthetic conversion of L-(indole-15N)tryptophan to (10-15N)anthramycin using (13C,15N) labelling in conjunction with 13C-NMR and mass spectral analysis.

1980 ◽  
Vol 33 (10) ◽  
pp. 1167-1171 ◽  
Author(s):  
JOHN M. OSTRANDER ◽  
LAURENCE H. HURLEY ◽  
A. GAVIN MCINNES ◽  
DONALD G. SMITH ◽  
JOHN A. WALTER ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
13C Nmr ◽  
Mass Spectral Analysis ◽  
15N Labelling ◽  
Mass Spectral

scholarly journals Synthesis and characterization of some chalcones and their cyclohexenone derivatives

2010 ◽  
Vol 8 (1) ◽  
pp. 174-181 ◽  
Author(s):  
Thekke Sreevidya ◽  
Badiadka Narayana ◽  
Hemmige Yathirajan
Keyword(s):  
Spectral Analysis ◽  
Ethyl Acetoacetate ◽  
Aldol Condensation ◽  
Synthesis And Characterization ◽  
Mass Spectral Analysis ◽  
X Ray ◽  
Mass Spectral ◽  
Aryl Aldehydes ◽  
Cyclohexenone Derivatives

AbstractA series of chalcones and their derivatives have been synthesized. Chalcones, 1-(1,3-benzodioxol-5-yl)-3-(aryl)-prop-2-en-1-ones were prepared by the aldol condensation of 1-(1,3-benzodioxol-5-yl)ethanones and aryl aldehydes. Based-catalyzed condensation of 1-(1,3-benzodioxol-5-yl)-3-(aryl)prop-2-en-1-ones with ethyl acetoacetate yields corresponding ethyl 4-(1,3-benzodioxol-5-yl)-6-(aryl)-2-oxocyclohex-3-ene-1-carboxylates. Some of the synthesized chalcones were reported in the literature; the newly synthesized compounds were characterized by single crystal X-ray studies, IR, 1H-NMR and LCMS mass spectral analysis.

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