scholarly journals 1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole

Molbank ◽  
10.3390/m1023 ◽  
2018 ◽  
Vol 2018 (4) ◽  
pp. M1023 ◽  
Author(s):  
Jean Guillon ◽  
Solène Savrimoutou ◽  
Sandra Rubio ◽  
Vanessa Desplat
Keyword(s):  
Spectral Analysis ◽  
Cell Lines ◽  
13C Nmr ◽  
Title Compound ◽  
Indole Derivative ◽  
Leukemia Cell ◽  
Structure Characterization ◽  
Cytotoxic Potential ◽  
Leukemia Cell Lines

The 1-methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole compound has been successfully synthesized via a multistep pathway starting from 2-phenylindole. Structure characterization of this new indole derivative was done by FTIR, 1H-NMR, 13C-NMR, and HRMS spectral analysis. The title compound showed high cytotoxic potential against five leukemia cell lines (K562, HL60, U937, U266, and Jurkat cell lines).

scholarly journals 1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity

Molbank ◽  
10.3390/m1113 ◽  
2020 ◽  
Vol 2020 (1) ◽  
pp. M1113
Author(s):  
Jean Guillon ◽  
Solène Savrimoutou ◽  
Sandra Rubio ◽  
Stéphane Moreau ◽  
Noël Pinaud ◽  
...  
Keyword(s):  
Leukemia Cell ◽  
Structure Characterization ◽  
Human Leukemia ◽  
U937 Cells ◽  
Quinoxaline Derivative ◽  
Cytotoxic Potential ◽  
X Ray ◽  
Leukemia Cell Lines ◽  
Ft Ir

1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-a]quinoxaline derivative was achieved by FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells).

scholarly journals 3-(3,5-Difluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Molbank ◽  
10.3390/m1011 ◽  
2018 ◽  
Vol 2018 (3) ◽  
pp. M1011 ◽  
Author(s):  
Naveen Kumar ◽  
Swamy Sreenivasa ◽  
Vasantha Kumar ◽  
Nadigar Mohan
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
High Purity ◽  
Title Compound ◽  
Good Yield ◽  
Phosphorus Oxychloride ◽  
Structure Characterization ◽  
Dimethyl Formamide

Vilsmeier–Haack reaction of (E)-1-[1-(3,5-difluorophenyl)ethylidene]-2-phenylhydrazine (1) using dimethyl formamide in excess of phosphorus oxychloride by conventional method, resulted in the synthesis of the title compound 3-(3,5-difluorophenyl)-1-phenyl-1H-pyrazole-4- carbaldehyde (2) in good yield and high purity. Structure characterization of the title compound was done by IR, 1H-NMR, 13C-NMR and HRMS spectral analysis.

scholarly journals 3-(3,5-Difluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

2018 ◽  
Author(s):  
Naveen Kumar ◽  
Swamy Sreenivasa ◽  
Vasantha Kumar ◽  
Nadigar Revansiddappa Mohan
Keyword(s):  
Spectral Analysis ◽  
13C Nmr ◽  
Title Compound ◽  
Structure Characterization ◽  
Dimethyl Formamide ◽  
The Novel ◽  
Mass Spectral Analysis ◽  
Mass Spectral ◽  
Phosphorous Oxychloride

Vilsmeier–Haack reaction of (E)-1-(1-(3,5-difluorophenyl)ethylidene)-2-phenylhydrazine (1) using dimethyl formamide in excess of phosphorous oxychloride by conventional method, resulted in the synthesis of title compound 3-(3,5-difluorophenyl)-1-phenyl-1H-pyrazole-4- carbaldehyde (2) in good yield and high purity. Structure characterization of the novel title compound was done by IR, 1H NMR, 13C NMR and mass spectral analysis.

scholarly journals Kasumi leukemia cell lines: characterization of tumor genomes with ethnic origin and scales of genomic alterations

Human Cell ◽  
2020 ◽  
Vol 33 (3) ◽  
pp. 868-876 ◽  
Author(s):  
Fumio Kasai ◽  
Hiroya Asou ◽  
Midori Ozawa ◽  
Kazuhiko Kobayashi ◽  
Hiroyuki Kuramitsu ◽  
...  
Keyword(s):  
Cell Lines ◽  
Leukemia Cell ◽  
Ethnic Origin ◽  
Genomic Alterations ◽  
Leukemia Cell Lines

Characterization of 4-O-methyl-ascochlorin-induced apoptosis in comparison with typical apoptotic inducers in human leukemia cell lines

APOPTOSIS ◽  
2004 ◽  
Vol 9 (4) ◽  
pp. 429-435 ◽  
Author(s):  
M. Tsuruga ◽  
H. Nakajima ◽  
S. Ozawa ◽  
M. Togashi ◽  
Y.-C. Chang ◽  
...  
Keyword(s):  
Cell Lines ◽  
Leukemia Cell ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Leukemia Cell Lines ◽  
Induced Apoptosis

scholarly journals Molecular Cytogenetic Characterization of Drug-resistant Leukemia Cell Lines by Comparative Genomic Hybridization and Fluorescencein situHybridization

2002 ◽  
Vol 93 (8) ◽  
pp. 902-910 ◽  
Author(s):  
Hajime Shimizu ◽  
Takeaki Fukuda ◽  
Mohammad Ghazizadeh ◽  
Mikio Nagashima ◽  
Oichi Kawanami ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Cell Lines ◽  
Leukemia Cell ◽  
Comparative Genomic ◽  
Drug Resistant ◽  
Genomic Hybridization ◽  
Molecular Cytogenetic ◽  
Leukemia Cell Lines ◽  
Cytogenetic Characterization

Molecular and Immunophenotypical Characterization of Progressive and Regressive Leukemia Cell Lines

2005 ◽  
Vol 20 (3) ◽  
pp. 290-299 ◽  
Author(s):  
Siguo Hao ◽  
Xuguang Bi ◽  
Liping Su ◽  
Weifeng Dong ◽  
Terence Moyana ◽  
...  
Keyword(s):  
Cell Lines ◽  
Leukemia Cell ◽  
Leukemia Cell Lines
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