scholarly journals Predictors of Spontaneous Remodelling of Angular Knee Deformities in Children with Healed Nutritional Rickets: A Prospective Cohort Study Protocol

2021 ◽  
Author(s):  
Mostafa M. Baraka ◽  
Shady Samir ◽  
Shady Mahmoud ◽  
Heba Elsedfy ◽  
Rana A. Mahmoud ◽  
...  
Keyword(s):  
Natural History ◽  
Study Protocol ◽  
Deformity Correction ◽  
Developed Countries ◽  
Primary Objective ◽  
Related Factors ◽  
Nutritional Rickets ◽  
History Of Disease ◽  
History Of ◽  
Disease Study

Background: Nutritional rickets is still considered as a global health problem especially in low-resource countries and immigrant societies of developed countries. Generalized skeletal deformities including angular knee deformities as genu varum and genu valgum are prominent features of nutritional rickets. Angular knee deformities can cause gait difficulties. However, the true remodelling potential of the healed knee deformities is largely unknown to the pediatric and orthopedic community. Aims: The primary objective of this study protocol is to investigate the natural history of disease in regard to the remodelling potential of angular knee deformities in children and adolescents with healed nutritional rickets. And determine the potential patient- and deformity-related factors that are associated with a favorable deformity remodelling as age and sex of patients and type, severity, laterality of deformities etc. Methods: This will be a prospective observational analytical cohort natural history of disease study. A minimum of at least 140 knees with healed nutritional rickets and angular knee deformities will be observed at regular three-monthly intervals over a period of at least one year. We will report two outcome variables namely; clinical and radiological tibio-femoral angle. And independent patient and deformity-related variables as age, sex, deformity type, severity and laterality. Inferential statistics namely bivariate and multivariate analysis will be employed accordingly to identify the relation between outcome variables and the different independent variables. Ethics and dissemination: This protocol study has been approved by the institutional research ethics committee. Results will be presented at conferences and submitted to relevant international and society publications. Authors will also communicate the results to their scholarly networks and post them on scholarly networking sites. Conclusions: This study has the potential for improving the decision-making process as to which patients deserve conservative treatment and which deserve surgical deformity correction. Results are expected to have an impact on the clinical practice of pediatricians, orthopedic surgeons and family physicians alike.

The Natural History of Knee Osteoarthritis: India-based Knee Osteoarthritis Evaluation (iKare): A Study Protocol

2013 ◽  
Vol 23 (2-03) ◽  
pp. 93-104
Author(s):  
Alexa Gilbert ◽  
Chuan Silvia Li ◽  
Parag Sancheti ◽  
Beate Hanson ◽  
Mandeep S. Dhillon ◽  
...  
Keyword(s):  
Natural History ◽  
Knee Osteoarthritis ◽  
Study Protocol ◽  
History Of

scholarly journals REVIEW ON THE CONCEPT OF SHAT KRIYAKALA

2022 ◽  
Vol 12 (6) ◽  
pp. 56-60
Author(s):  
Anu P Baby ◽  
Jigeesh PP
Keyword(s):  
Natural History ◽  
Early Stage ◽  
Disease Process ◽  
Pathological Process ◽  
Stage Of Development ◽  
Long Run ◽  
History Of Disease ◽  
Accurate Treatment ◽  
Current Scenario ◽  
History Of

Diagnosis in Ayurveda is not always in terms of the name of the disease but in terms of the nature or phenomenon. This phenomenon is described in terms of Samprapti of the disease in each patient, comprising Dosha, Dushya and Adhishtana components. The prime factors in the pathogenesis of the disease are Dosha and Dushya. Shat kriyakala refers to the stage of development of a pathological process in which a physician can intervene by the most accurate treatment modality and medicine, thereby halting the progression of the disease process. By intricate understanding of the process of Shat kriyakala, the disease process could be arrested, and further complications can be avoided. In the current scenario, the concept of prevention has become broad-based. The natural history of disease is one of the significant elements of epidemiology. The course of a disease takes in individual people from its pathological onset until its eventual resolution. Natural history of disease is possible to correlate pre-pathogenesis with Sanchaya, Prakopa, Prasara and pathogenesis with Sthanasamsraya, Vyakti and Bhedavastha of Shat kriyakala. Recent studies have shown that it is possible to identify certain pre-clinical stages for many diseases like Parkinson’s disease, which can help in the early successful treatment. Shat kriyakala helps to arrest the disease process at the very early stage itself. Along with current technology, the need for research for validating the Shat kriyakala will benefit humankind in the long run.

scholarly journals Spontaneous thrombosis of internal carotid artery: a natural history of giant carotid cavernous aneurysms

2009 ◽  
Vol 67 (2a) ◽  
pp. 278-283 ◽  
Author(s):  
Lucas Perez de Vasconcellos ◽  
Juan Antônio Castro Flores ◽  
Mário Luiz Marques Conti ◽  
José Carlos Esteves Veiga ◽  
Carmen Lúcia Penteado Lancellotti
Keyword(s):  
Carotid Artery ◽  
Natural History ◽  
Internal Carotid Artery ◽  
Collateral Circulation ◽  
Internal Carotid ◽  
Clinical Presentation ◽  
Spontaneous Thrombosis ◽  
Related Factors ◽  
Trigeminal Neuropathy ◽  
History Of

OBJECTIVE: To describe five cases of giant carotid cavernous aneurysms which evolved with spontaneous thrombosis of internal carotid artery (STICA), with emphasis at epidemiology, clinical presentation, natural history, related factors and neurological outcome. METHOD: There were 711 consecutives patients with 802 aneurysms with and without surgical treatment during a period of 19 years. We selected 35 patients with 40 carotid cavernous aneurysms (5%) of which 20 (50%) were giant aneurysms. Among those cases, 5 patients evolved with STICA (25%). Symptoms and findings at presentation were recorded and compared with those at outcome. RESULTS: Clinical presentation was commonly related to atherosclerotic factors such as elevated blood pressure (80%), diabetes mellitus (40%) and dislipidemy (40%). All patients presented with hemicranial headache, ophthalmparesy and retro bulbar pain, and after STICA all presented improvement of symptoms. After STICA, 4 patients had regression of deficit, 2 partial and 2 complete. Four patients had sensorial trigeminal neuropathy in V1 and V2 territories, also showing improvement of symptoms after STICA. CONCLUSION: STICA is a common outcome in giant carotid cavernous aneurysms, and is related with significant improvement of symptoms; however, it may be catastrophic for those patients without efficient collateral circulation.

scholarly journals Su1463 – Natural History of Disease Progression and Interventions After Aborted Pancreatoduodenectomy for Pancreatic Adenocarcinoma

2019 ◽  
Vol 156 (6) ◽  
pp. S-1445
Author(s):  
Timothy J. Vreeland ◽  
Timothy E. Newhook ◽  
Laura R. Prakash ◽  
Whitney L. Dewhurst ◽  
Morgan L. Bruno ◽  
...  
Keyword(s):  
Natural History ◽  
Disease Progression ◽  
Pancreatic Adenocarcinoma ◽  
History Of Disease ◽  
History Of
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