scholarly journals 1H-NMR based metabolomic profiling of cord blood in gestational hypothyroidism

2020 ◽  
Vol 8 (6) ◽  
pp. 296-296
Author(s):  
Chunchao Zhao ◽  
Jun Ge ◽  
Ruifen Jiao ◽  
Xia Li ◽  
Yuan Li ◽  
...  
2020 ◽  
Vol 5 ◽  
pp. 264
Author(s):  
Kurt Taylor ◽  
Nancy McBride ◽  
Neil J Goulding ◽  
Kimberley Burrows ◽  
Dan Mason ◽  
...  

Metabolomics is the quantification of small molecules, commonly known as metabolites. Collectively, these metabolites and their interactions within a biological system are known as the metabolome. The metabolome is a unique area of study, capturing influences from both genotype and environment. The availability of high-throughput technologies for quantifying large numbers of metabolites, as well as lipids and lipoprotein particles, has enabled detailed investigation of human metabolism in large-scale epidemiological studies. The Born in Bradford (BiB) cohort includes 12,453 women who experienced 13,776 pregnancies recruited between 2007-2011, their partners and their offspring. In this data note, we describe the metabolomic data available in BiB, profiled during pregnancy, in cord blood and during early life in the offspring. These include two platforms of metabolomic profiling: nuclear magnetic resonance and mass spectrometry. The maternal measures, taken at 26-28 weeks’ gestation, can provide insight into the metabolome during pregnancy and how it relates to maternal and offspring health. The offspring cord blood measurements provide information on the fetal metabolome. These measures, alongside maternal pregnancy measures, can be used to explore how they may influence outcomes. The infant measures (taken around ages 12 and 24 months) provide a snapshot of the early life metabolome during a key phase of nutrition, environmental exposures, growth, and development. These metabolomic data can be examined alongside the BiB cohorts’ extensive phenotype data from questionnaires, medical, educational and social record linkage, and other ‘omics data.


2018 ◽  
Vol 106 ◽  
pp. 870-877 ◽  
Author(s):  
Nemesio Villa-Ruano ◽  
Rodolfo Velásquez-Valle ◽  
L. Gerardo Zepeda-Vallejo ◽  
Nury Pérez-Hernández ◽  
Manuel Velázquez-Ponce ◽  
...  

2016 ◽  
Vol 5 (4) ◽  
pp. 1148-1159 ◽  
Author(s):  
Shanting Liao ◽  
Pei Li ◽  
Junsong Wang ◽  
Qian Zhang ◽  
Dingqiao Xu ◽  
...  

LPS disturbed the metabolomic profiles in the serum, livers and kidneys of mice, and baicalin ameliorated these disturbances.


Metabolites ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 201 ◽  
Author(s):  
Shirin Macias ◽  
Joseph Kirma ◽  
Ali Yilmaz ◽  
Sarah E. Moore ◽  
Michelle C. McKinley ◽  
...  

The Mediterranean diet (MD) is a dietary pattern well-known for its benefits in disease prevention. Monitoring adherence to the MD could be improved by discovery of novel dietary biomarkers. The MEDiterranean Diet in Northern Ireland (MEDDINI) intervention study monitored the adherence of participants to the MD for up to 12 months. This investigation aimed to profile plasma metabolites, correlating each against the MD score of participants (n = 58). Based on an established 14-point scale MD score, subjects were classified into two groups (“low” and “high”). 1H-Nuclear Magnetic Resonance (1H-NMR) metabolomic analysis found that citric acid was the most significant metabolite (p = 5.99 × 10−4*; q = 0.03), differing between ‘low’ and ‘high’. Furthermore, five additional metabolites significantly differed (p < 0.05; q < 0.35) between the two groups. Discriminatory metabolites included: citric acid, pyruvic acid, betaine, mannose, acetic acid and myo-inositol. Additionally, the top five most influential metabolites in multivariate models were also citric acid, pyruvic acid, betaine, mannose and myo-inositol. Metabolites significantly correlated with the consumption of certain food types. For example, citric acid positively correlated fruit, fruit juice and vegetable constituents of the diet, and negatively correlated with sweet foods alone or when combined with carbonated drinks. Citric acid was the best performing biomarker and this was enhanced by paired ratio with pyruvic acid. The present study demonstrates the utility of metabolomic profiling for effectively assessing adherence to MD and the discovery of novel dietary biomarkers.


Metabolomics ◽  
2014 ◽  
Vol 11 (3) ◽  
pp. 594-602 ◽  
Author(s):  
Alvaro M. Viljoen ◽  
Jianping Zhao ◽  
Maxleene Sandasi ◽  
Weiyang Chen ◽  
Ikhlas A. Khan

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e75998 ◽  
Author(s):  
Eun-Young Won ◽  
Mi-Kyung Yoon ◽  
Sang-Woo Kim ◽  
Youngae Jung ◽  
Hyun-Whee Bae ◽  
...  

RSC Advances ◽  
2017 ◽  
Vol 7 (72) ◽  
pp. 45385-45392 ◽  
Author(s):  
Francisco Javier Martínez-López ◽  
Angel E. Bañuelos-Hernández ◽  
Elvia Becerra-Martínez ◽  
Eduardo Santini-Araujo ◽  
Ruben A. Amaya-Zepeda ◽  
...  

1H NMR metabolomic profiling for giant cell tumor of the bone.


PLoS ONE ◽  
2010 ◽  
Vol 5 (10) ◽  
pp. e13223 ◽  
Author(s):  
Hélène Blasco ◽  
Philippe Corcia ◽  
Caroline Moreau ◽  
Ségolène Veau ◽  
Clémentine Fournier ◽  
...  

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