The Society for Translational Medicine: indications and methods of percutaneous transthoracic needle biopsy for diagnosis of lung cancer

The number of patients with lung cancer is difficultly diagnosed in the early stage. The purpose of the study was to investigate the effects of CT- and ultrasound-guided percutaneous transthoracic needle biopsy combined with serum CA125 and CEA on the diagnosis of lung cancer. 120 patients with suspected lung cancer admitted to our hospital from January 2019 to January 2020 were selected and divided into an ultrasound group (n = 60) and CT group (n = 60), according to different percutaneous transthoracic needle biopsy modalities. All patients received serum tumor markers detection, so as to compare the CT- and ultrasound-guided percutaneous transthoracic needle biopsy results and pathology results, levels of serum tumor markers among all patients and the patients with different lung cancer types, and diagnostic efficacy of tumor markers, as well as complication rate (CR) in patients. The sensitivity and specificity of ultrasound-guided percutaneous transthoracic needle biopsy were 0.880 and 0.800, respectively, while those of CT-guided percutaneous transthoracic needle biopsy were 0.909 and 0.625, respectively; the CA125 and CEA levels in the lung cancer group were higher than those in the benign group ( P < 0.001 ); the CA125 and CEA levels of the patients with adenocarcinoma were higher than those with squamous carcinoma, and the CEA levels of the patients with small-cell carcinoma were lower than those with adenocarcinoma ( P < 0.05 ); the sensitivity, specificity, and Youden indexes of CA125 were 0.638, 0.833, and 0.471, respectively, while those of CEA were 0.766, 0.778, and 0.544, respectively; there were no significant differences in CR between the two groups ( P > 0.05 ). CT- and ultrasound-guided percutaneous transthoracic needle biopsy is a safe and feasible diagnostic modality for lung cancer, and its combination with serum CA125 and CEA can significantly improve the accuracy of the detection results, which is worthy of promotion and application in clinical practice.

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Preoperative Percutaneous Transthoracic Needle Biopsy Increased the Risk of Pleural Recurrence in Pathological Stage I Lung Cancer Patients With Sub-pleural Pure Solid Nodules

Cancer Investigation ◽

10.1080/07357907.2016.1212061 ◽

2016 ◽

Vol 34 (8) ◽

pp. 373-377 ◽

Cited By ~ 7

Author(s):

Kosuke Kashiwabara ◽

Hiroshi Semba ◽

Shinji Fujii ◽

Shinsuke Tsumura

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Needle Biopsy ◽

Stage I ◽

Pathological Stage ◽

Transthoracic Needle Biopsy ◽

Lung Cancer Patients ◽

Stage I Lung Cancer ◽

Percutaneous Transthoracic Needle Biopsy

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Correlation between percutaneous transthoracic needle biopsy and recurrence in stage I lung cancer: a systematic review and meta-analysis

BMC Pulmonary Medicine ◽

10.1186/s12890-020-01235-2 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Haichao Li ◽

Rong Chen ◽

Jian Zhao

Keyword(s):

Lung Cancer ◽

Systematic Review ◽

Needle Biopsy ◽

Meta Analysis ◽

Stage I ◽

Transthoracic Needle Biopsy ◽

Stage I Lung Cancer ◽

Percutaneous Transthoracic Needle Biopsy

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Correlation between percutaneous transthoracic needle biopsy and recurrence in stage I lung cancer: a systematic review and meta-analysis

10.21203/rs.3.rs-32116/v1 ◽

2020 ◽

Author(s):

Haichao Li ◽

Rong Chen ◽

Jian Zhao

Keyword(s):

Lung Cancer ◽

Needle Biopsy ◽

Meta Analysis ◽

Tumor Location ◽

Stage I ◽

Cochrane Library ◽

Transthoracic Needle Biopsy ◽

Lung Cancer Patients ◽

Stage I Lung Cancer ◽

Percutaneous Transthoracic Needle Biopsy

Abstract Objective To systematically evaluate the correlation between percutaneous transthoracic needle biopsy (PTNB) and recurrence in stage I lung cancer. Methods The databases of PubMed, EMbase, The Cochrane Library, CNKI, WanFang Data and China Biology Medicine disc were retrieved to collect relevant literatures about the correlation between percutaneous transthoracic needle biopsy(PTNB) and recurrence in stage I lung cancer. The retrieval time was limited from the time of their database establishment to April 30/2020.Screened the literature, extracted the data and assessed the quality of studies included. Then the meta-analysis was performed by using Stata l6.0 software. Results A total of 8 cohort studies involving 2760 lung cancer patients were included. The results of meta-analysis showed that PTNB did not increase the risk of total recurrence and pleural recurrence in the patients with stage I lung cancer.The result of subgroup analysis is according to the tumor location. For stage I lung cancer, PTNB will increase the risk of pleural recurrence in patients with sub-pleural lesions but not in those without sub-pleural lesions. Conclusion To stage I lung cancer, PTNB is not associated with the total recurrence and pleural recurrence but PTNB will increase the risk of pleural recurrence in patients with sub-pleural lesions.

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Correlation between percutaneous transthoracic needle biopsy and recurrence in stage I lung cancer: a systematic review and meta-analysis

10.21203/rs.3.rs-32116/v2 ◽

2020 ◽

Author(s):

Haichao Li ◽

Rong Chen ◽

Jian Zhao

Keyword(s):

Lung Cancer ◽

Needle Biopsy ◽

Meta Analysis ◽

Tumor Location ◽

Stage I ◽

Cochrane Library ◽

Transthoracic Needle Biopsy ◽

Lung Cancer Patients ◽

Stage I Lung Cancer ◽

Percutaneous Transthoracic Needle Biopsy

Abstract Background To systematically evaluate the correlation between percutaneous transthoracic needle biopsy (PTNB) and recurrence in stage I lung cancer.Methods The databases of PubMed, EMbase, The Cochrane Library, CNKI, WanFang Data and China Biology Medicine disc were retrieved to collect relevant literatures about the correlation between PTNB and recurrence in stage I lung cancer. The retrieval time was limited from the time of their database establishment to April 30/2020．Screened the literature, extracted the data and assessed the quality of studies included. Then the meta-analysis was performed by using Stata l6.0 software.Results A total of 8 cohort studies involving 2760 lung cancer patients were included. The results of meta-analysis showed that PTNB did not increase the risk of total recurrence and pleural recurrence in the patients with stage I lung cancer．The result of subgroup analysis is according to the tumor location. For stage I lung cancer, PTNB will increase the risk of pleural recurrence in patients with sub-pleural lesions but not in those without sub-pleural lesions.Conclusions To stage I lung cancer, PTNB is not associated with the total recurrence and pleural recurrence but PTNB will increase the risk of pleural recurrence in patients with sub-pleural lesions.

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Tissue Adequacy and Safety of Percutaneous Transthoracic Needle Biopsy for Molecular Analysis in Non-Small Cell Lung Cancer: A Systematic Review and Meta-analysis

Korean Journal of Radiology ◽

10.3348/kjr.2021.0244 ◽

2021 ◽

Vol 22 ◽

Author(s):

Bo Da Nam ◽

Soon Ho Yoon ◽

Hyunsook Hong ◽

Jung Hwa Hwang ◽

Jin Mo Goo ◽

...

Keyword(s):

Lung Cancer ◽

Systematic Review ◽

Small Cell Lung Cancer ◽

Molecular Analysis ◽

Needle Biopsy ◽

Meta Analysis ◽

Small Cell ◽

Small Cell Lung ◽

Transthoracic Needle Biopsy ◽

Percutaneous Transthoracic Needle Biopsy

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Diagnostic Percutaneous Transthoracic Needle Biopsy Does Not Affect Survival in Stage I Lung Cancer

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.200602-160oc ◽

2006 ◽

Vol 174 (6) ◽

pp. 684-688 ◽

Cited By ~ 27

Author(s):

Juan P. Wisnivesky ◽

Claudia I. Henschke ◽

David F. Yankelevitz

Keyword(s):

Lung Cancer ◽

Needle Biopsy ◽

Stage I ◽

Transthoracic Needle Biopsy ◽

Stage I Lung Cancer ◽

Percutaneous Transthoracic Needle Biopsy

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Risk of Pleural Recurrence in Early Stage Lung Cancer Patients after Percutaneous Transthoracic Needle Biopsy: A Meta-analysis

Scientific Reports ◽

10.1038/srep42762 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 4

Author(s):

Ting Wang ◽

Lili Luo ◽

Qinghua Zhou

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Needle Biopsy ◽

Early Stage ◽

Meta Analysis ◽

Early Stage Lung Cancer ◽

Transthoracic Needle Biopsy ◽

Lung Cancer Patients ◽

Percutaneous Transthoracic Needle Biopsy ◽

Stage Lung Cancer

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Does percutaneous transthoracic needle biopsy increase the risk of pleural recurrence in patients with stage I lung cancer?

Interactive Cardiovascular and Thoracic Surgery ◽

10.1093/icvts/ivaa027 ◽

2020 ◽

Vol 30 (6) ◽

pp. 834-838

Author(s):

Diou Cheng ◽

Zihuai Wang ◽

Jian Cui ◽

Lunxu Liu

Keyword(s):

Lung Cancer ◽

Cohort Studies ◽

Needle Biopsy ◽

Meta Analysis ◽

The Other ◽

Stage I ◽

Transthoracic Needle Biopsy ◽

Stage I Lung Cancer ◽

Study Type ◽

Percutaneous Transthoracic Needle Biopsy

Abstract A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was: does percutaneous transthoracic needle biopsy (PTNB) increase the risk of pleural recurrence in patients with stage I lung cancer? Altogether, 298 papers were found using the reported search, of which 7 cohort studies and 1 meta-analysis represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers were tabulated. Four cohort studies suggested an association between PTNB and pleural recurrence in patients with stage I lung cancer, while the other 3 cohort studies found that PTNB had no impact. One meta-analysis (the largest study) including 5 of the cohort studies above concluded that PTNB increased the risk of pleural recurrence among patients with stage I lung cancer with subpleural lesions. Based on the available evidence, it was suggested that there may be an association between PTNB and pleural recurrence in patients with stage I lung cancer, especially for patients with subpleural lesion.

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