scholarly journals Effects of insulin-like growth factor binding protein 3 on cell growth and tumorigenesis in oral squamous cell carcinoma

2019 ◽  
Vol 8 (5) ◽  
pp. 1709-1717
Author(s):  
Hong-Yuan Xu ◽  
Dong-Wang Zhu ◽  
Lai-Ping Zhong ◽  
Zhi-Yuan Zhang ◽  
Cheng-Zhe Yang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Growth ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

Insulin-like growth factor binding protein-3, in association with IGF-1 receptor, can predict prognosis in squamous cell carcinoma of the head and neck

Oral Oncology ◽  
2011 ◽  
Vol 47 (8) ◽  
pp. 714-719 ◽  
Author(s):  
Jong-Mu Sun ◽  
Hyun Jung Jun ◽  
Young Hyeh Ko ◽  
Yeon Hee Park ◽  
Yong Chan Ahn ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Effects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells

2018 ◽  
Vol Volume 11 ◽  
pp. 6569-6577 ◽  
Author(s):  
Jinli Liu ◽  
Yuanyuan Guo ◽  
Yuanyuan Huang ◽  
Haowei Xue ◽  
Suwen Bai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Binding Protein ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Carcinoma Cells ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway

2020 ◽  
Author(s):  
Danning Wang ◽  
Jinlan Gao ◽  
Chenyang Zhao ◽  
Sen Li ◽  
Di Zhang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Cyclin G2 ◽  
A Cell

AbstractThe cell cycle protein cyclin G2 is considered a tumor suppressor. However, its regulatory effects and potential mechanisms in oral cancers are not well understood. This study aimed to investigate the effect of cyclin G2 on oral squamous cell carcinoma (OSCC). The data from 80 patients with OSCC were utilized to predict the abnormal expression of cyclin G2. The proliferation and metastasis were determined by a cell counting Kit-8 assay, flow cytometry, a wound-healing assay and a cell invasion assay. The expression of key proteins and genes associated with the cyclin G2 signaling pathways was determined by western blotting and real-time PCR, respectively. The orthotopic nude mice model was established by a mouth injection of SCC9 cells overexpressing cyclin G2. We showed that the low level of cyclin G2 in OSCC, which is negatively correlated with clinical staging, was a negative prognostic factor for the disease. We also found that cyclin G2 inhibited the proliferation, metastasis and blocked the cell cycle at G1/S of OSCC cells, suggesting that cyclin G2 has an inhibitory effect in OSCC. Mechanistically, cyclin G2 inhibited the growth and metastasis of OSCC by binding to insulin-like growth factor binding protein 3 (IGFBP3) and regulating the focal adhesion kinase (FAK) -SRC-STAT signal transduction pathway. Cyclin G2 competed with integrin to bind to IGFBP3; the binding between integrin and IGFBP3 was reduced after cyclin G2 overexpression, thereby inhibiting the phosphorylation of FAK and SRC. These results showed that cyclin G2 inhibited the progression of OSCC by interacting with IGFBP3 and that it may be a new target for OSCC treatment.

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