scholarly journals The natural history of drug use from adolescence to the mid-thirties in a general population sample.

1995 ◽  
Vol 85 (1) ◽  
pp. 41-47 ◽  
Author(s):  
K Chen ◽  
D B Kandel
1999 ◽  
Vol 26 (4) ◽  
pp. 695-710 ◽  
Author(s):  
John A. Cunningham ◽  
Anja Koski-Jännes ◽  
Tony Toneatto

1995 ◽  
Vol 10 (4) ◽  
pp. 175-182 ◽  
Author(s):  
MG Madianos ◽  
D Gefou-Madianou ◽  
CN Stefanis

SummaryA cross-sectional home survey on the epidemiology of drug use in Greece, with a nationwide general population sample of 4,291 respondents aged 12 to 64, was carried out. The weighted life prevalence of reported illicit drug use in the total sample was found to be 9% among males and 2.5% among females, with a ratio of 3.6: 1. Six and a half percent of males of all ages had used, at some time, licit psychotropic drugs without a doctor's order, while females presented much higher prevalence rates (14.9%). Young adults reported higher rates of both illicit and licit lifetime and past-year use, compared to the other age groups. Illicit drug use was less common, in females of all ages. Cannabis was the most common illicit drug used. Current as well as lifetime use of pain relievers without a doctor's prescription was found to be highest among all other licit substances. This holds true for all age groups and for both sexes. Tranquillizers were predominantly used by females of all ages. Certain sociodemographic variables, such as sex, educational level, marital status, place of residence and occupational status were found to be related to drug use in Greece.


2013 ◽  
Vol 170 (6) ◽  
pp. 660-670 ◽  
Author(s):  
Wilson M. Compton ◽  
Deborah A. Dawson ◽  
Kevin P. Conway ◽  
Marc Brodsky ◽  
Bridget F. Grant

EP Europace ◽  
2020 ◽  
Author(s):  
Maria Munk Pærregaard ◽  
Sara Osted Hvidemose ◽  
Christian Pihl ◽  
Anne-Sophie Sillesen ◽  
Solmaz Bagheri Parvin ◽  
...  

Abstract Aims Evaluation of the neonatal QT interval is important to diagnose arrhythmia syndromes and evaluate side effects of drugs. We aimed at describing the natural history of the QT interval duration during the first 4 weeks of life and to provide reference values from a large general population sample. Methods and results The Copenhagen Baby Heart Study is a prospective general population study that offered cardiac evaluation of newborns. Eight-lead electrocardiograms were obtained and analysed with a computerized algorithm with manual validation. We included 14 164 newborns (52% boys), aged 0–28 days, with normal echocardiograms. The median values (ms, 2–98%ile) for the corrected intervals QTc (Bazett), QTc (Hodges), QTc (Fridericia), and QTc (Framingham) were 419 (373–474), 419 (373–472), 364 (320–414), and 363 (327–405). During the 4 weeks, we observed a small decrease of QTcFramingham, and an increase of QTcHodges (both P < 0.01), while QTcBazett and QTcFridericia did not change (P > 0.05). Applying published QT interval cut-off values resulted in 5–25% of the newborns having QT prolongation. Uncorrected QT intervals decreased linearly with increasing heart rate (HR). Sex and infant size did not affect the QT interval and the gestational age (GA) only showed an effect when comparing the extreme low- vs. high GA groups (≤34 vs. ≥42 weeks, P = 0.021). Conclusion During the 4 weeks QTcFramingham and QTcHodges showed minor changes, whereas QTcBazett and QTcFridericia were stable. The QT interval was unaffected by sex and infant size and GA only showed an effect in very premature newborns. Reference values for HR-specific uncorrected QT intervals may facilitate a more accurate diagnosis of newborns with abnormal QT intervals.


Addiction ◽  
2016 ◽  
Vol 112 (3) ◽  
pp. 477-485 ◽  
Author(s):  
Michelle Taylor ◽  
John Sullivan ◽  
Susan M. Ring ◽  
John Macleod ◽  
Matthew Hickman

2014 ◽  
Vol 3 (4) ◽  
pp. 277-287 ◽  
Author(s):  
Kristina Sinadinovic ◽  
Peter Wennberg ◽  
Anne H. Berman

Sinadinovic, K., Wennberg, P., & Berman, A. (2014). Short-term changes in substance use among problematic alcohol and drug users from a general population sample. The International Journal Of Alcohol And Drug Research, 3(4), 277-287. doi:http://dx.doi.org/10.7895/ijadr.v3i4.186Aims: To investigate 12-month changes among individuals with baseline problematic use of alcohol or illicit drugs, by gender, age, initial level of substance use, and administration method (Internet or Interactive Voice Response, IVR).Design: 1,861 individuals from a random population sample were screened for problematic alcohol and illicit drug use. Individuals screening positive were followed up after 12 months.Setting: The Swedish general population.Participants: 423 individuals with baseline problematic alcohol (women: AUDIT ≥ 6, men: AUDIT ≥ 8) or drug use (both genders: DUDIT ≥ 1).Measures: AUDIT, DUDIT, AUDIT-C and DUDIT-C scores.Findings: AUDIT scores decreased from 10.43 to 8.62; among 239 participants with baseline problematic alcohol use, 34.3% no longer had problematic use at follow-up. Total DUDIT scores decreased from 4.92 to 2.33; among 51 participants with baseline problematic drug use, 60.8% reported no illicit drug use at follow-up. AUDIT and DUDIT scores decreased more for individuals who at baseline had harmful problematic use, compared to those who had hazardous baseline use. Within-group effect sizes for AUDIT and DUDIT scores varied between 0.29 and 0.69 (Cohen’s d).Conclusions: Data on short-term change in problematic substance use in a random general population sample could constitute a reference point for comparisons for uncontrolled treatment studies.


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